Výsledky vyhledávání - "Kai Yun Quek"

Akademický článek

iSECRETE: Integrating Microfluidics and DNA Proximity Amplification for Synchronous Single‐Cell Activation and IFN‐γ Secretion Profiling

Autor: Ri Lu, Yan Shan Ang, Ka‐Wai Cheung, Kai Yun Quek, Wei‐Xiang Sin, Elizabeth Lee, Shir Lynn Lim, Lin‐Yue Lanry Yung, Michael E. Birnbaum, Jongyoon Han, Lih Feng Cheow, Kerwin Kwek Zeming

Publikováno v: Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)

Abstract Cytokines, crucial in immune modulation, impact disease progression when their secretion is dysregulated. Existing methods for profiling cytokine secretion suffer from time‐consuming and labor‐intensive processes and often fail to captur

Externí odkaz: https://doaj.org/article/667d895d7fe443dd9e156f2e8184a4d5

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Multiplexed Single-Cell Leukocyte Enzymatic Secretion Profiling from Whole Blood Reveals Patient-Specific Immune Signature

Autor: Kai Lee Woo, Guoyun Sun, Kerwin Kwek Zeming, Ri Lu, Jongyoon Han, Chia-Hung Chen, Shir Lynn Lim, Kai Yun Quek, Lih Feng Cheow

Publikováno v: Analytical Chemistry. 93:4374-4382

Enzymatic secretion of immune cells (leukocytes) plays a dominant role in host immune responses to a myriad of biological triggers, including infections, cancers, and cardiovascular diseases. Current tools to probe these leukocytes inadequately profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642fefcae52746503bafe526f9cd807
https://doi.org/10.1021/acs.analchem.0c03512

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The effects of gelatin-dopamine coating on polydimethylsiloxane substrates on pluripotency maintenance and myocardial differentiation of cultured mouse embryonic stem cells

Autor: Kai Yun Quek, Changjiang Fan, Yon Jin Chuah, Chee Seong Lim, Dong-An Wang, Jiayin Fu

Publikováno v: Journal of materials chemistry. B. 4(48)

Polydimethylsiloxane (PDMS) is a common biomaterial in the fabrication of microfluidic devices due to its various beneficial properties. However, its inherent highly hydrophobic surfaces often limit PDMS-based microfluidic devices for myocardial diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178c2f1a3f669d5032074e40053afb42
https://pubmed.ncbi.nlm.nih.gov/32263786

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Inflammation Biomarkers: Label‐Free Biophysical Markers from Whole Blood Microfluidic Immune Profiling Reveal Severe Immune Response Signatures (Small 12/2021)

Autor: Kerwin Kwek Zeming, Rohan Vernekar, Timm Krüger, Kai Yun Quek, Win Sen Kuan, Greg Sutton, Mui Teng Chua, Jongyoon Han

Publikováno v: Small. 17:2170051

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58fa4249473f3531071dd30214ae43b9
https://doi.org/10.1002/smll.202170051

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Label‐Free Biophysical Markers from Whole Blood Microfluidic Immune Profiling Reveal Severe Immune Response Signatures

Autor: Mui Teng Chua, Win Sen Kuan, Kai Yun Quek, Greg Sutton, Kerwin Kwek Zeming, Rohan Vernekar, Jongyoon Han, Timm Krüger

Publikováno v: Zeming, K K, Vernekar, R, Chua, M T, Quek, K Y, Sutton, G, Krüger, T, Kuan, W S & Han, J 2021, ' Label-free biophysical markers from whole blood microfluidic immune profiling reveals severe immune response signatures ', Small . https://doi.org/10.1002/smll.202006123

Disease manifestation and severity from acute infections are often due to hyper-aggressive host immune responses which changes within minutes. Current methods for early diagnosis of infections focus on detecting low abundance pathogens, which are tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0654fbbaa0b271c1a0e124a67f1bfb9
https://doi.org/10.1002/smll.202006123

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