Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kai Yasukawa"'
Autor:
Tomo Takegawa-Araki, Kai Yasukawa, Norihiko Iwazaki, Hideto Maruyama, Hiroyuki Furukawa, Hiroaki Sawamoto, Satoshi Obika
Publikováno v:
Organic & Biomolecular Chemistry. 20:9351-9361
Efficient oligonucleotide synthesis by post elongation modification with direct acylation of 2′-amino-LNA and evaluation of their microRNA inhibitory activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3102ed001e207f28ca9ee40762c7d794
https://doi.org/10.1039/d2ob01809h
https://doi.org/10.1039/d2ob01809h
Autor:
Tomo Takegawa-Araki, Kai Yasukawa, Norihiko Iwazaki, Masayuki Utsugi, Hiroyuki Furukawa, Shinji Kumagai, Hiroaki Sawamoto, Satoshi Obika
Publikováno v:
Bioorganicmedicinal chemistry. 78
2'-Amino-LNA has the potential to acquire various functions through chemical modification at the 2'-nitrogen atom. This study focused on 2'-N-alkylaminocarbonyl 2'-amino-LNA, which is a derivative of 2'-amino-LNA. We evaluated its practical usefulnes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4a99e9c3f60892e25398e0925cb7ba
https://pubmed.ncbi.nlm.nih.gov/36580743
https://pubmed.ncbi.nlm.nih.gov/36580743
Publikováno v:
J Biol Chem
MicroRNAs (miRNAs) are small noncoding RNAs that suppress the expression of multiple genes and are involved in numerous biologic functions and disorders, including human diseases. Here, we report that two miRNAs, miR-302b and miR-372, target mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b8b89c6328a90c7438d355ac05c255
https://doi.org/10.1074/jbc.ra119.010511
https://doi.org/10.1074/jbc.ra119.010511
Autor:
Tomo Takegawa-Araki, Shinji Kumagai, Kai Yasukawa, Masataka Kuroda, Takashi Sasaki, Satoshi Obika
Publikováno v:
Journal of medicinal chemistry. 65(3)
Anti-microRNA oligonucleotides (AMOs) are valuable tools for the treatment of diseases caused by the dysregulation of microRNA expression. However, the correlation between chemical modifications in AMO sequences and the microRNA-inhibitory activity h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9790dd11984571b6717916e189fc01a0
https://pubmed.ncbi.nlm.nih.gov/35084859
https://pubmed.ncbi.nlm.nih.gov/35084859
Autor:
Takumi Koshiba, Kai Yasukawa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129839
Mitochondria are multi-functioning organelles that participate in a wide range of biologic processes from energy metabolism to cellular suicide. Mitochondria are also involved in the cellular innate immune response against microorganisms or environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa8e52dca0ff857c3aac79fcb6c0571
https://doi.org/10.1016/j.bbagen.2020.129839
https://doi.org/10.1016/j.bbagen.2020.129839
Publikováno v:
Fukuoka igaku zasshi = Hukuoka acta medica. 107(8)
Recent advances reveal that mitochondria are not limited to functioning only as the cellular powerhouse and in apoptosis, but that they act as central hubs for multiple signal transductions. Studies over the last decade indicate that mitochondria in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb463c1d044821ff80a2ef676cc55f10
https://pubmed.ncbi.nlm.nih.gov/29227063
https://pubmed.ncbi.nlm.nih.gov/29227063
Autor:
Kai Yasukawa1,2, Daisuke Kinoshita1, Keisuke Yaku3, Takashi Nakagawa3,4, Takumi Koshiba1,5 koshiba@kyudai.jp
Publikováno v:
Journal of Biological Chemistry. 1/10/2020, Vol. 295 Issue 2, p444-457. 14p.
Autor:
Shun Ichiro Kawabata, Kenji Kubara, Takumi Koshiba, Janet M. Shaw, Holly A. Holman, Jane L. Macfarlane, Kai Yasukawa, Koji Okamoto
Publikováno v:
Journal of Biological Chemistry. 286:354-362
Mitochondria undergo continuous cycles of homotypic fusion and fission, which play an important role in controlling organelle morphology, copy number, and mitochondrial DNA maintenance. Because mitochondria cannot be generated de novo, the motility a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::865b2278eabed9369b74b720570aafab
https://doi.org/10.1074/jbc.m110.180034
https://doi.org/10.1074/jbc.m110.180034
Publikováno v:
Science Signaling. 4
Mitochondria, dynamic organelles that undergo cycles of fusion and fission, are the powerhouses of eukaryotic cells and are also involved in cellular innate antiviral immunity in mammals. Mitochondrial antiviral immunity depends on activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfb2c0fdd37813c440b116768aa0a58
https://doi.org/10.1126/scisignal.2001147
https://doi.org/10.1126/scisignal.2001147
Autor:
Hiroyuki Oshiumi, Shun Ichiro Kawabata, Yusuke Yanagi, Takumi Koshiba, Naotada Ishihara, Tsukasa Seya, Makoto Takeda, Kai Yasukawa
Publikováno v:
Science Signaling. 2
The innate immune response to viral infection involves the activation of multiple signaling steps that culminate in the production of type I interferons (IFNs). Mitochondrial antiviral signaling (MAVS), a mitochondrial outer membrane adaptor protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1a8b74a819eef82f29326c88aa12b7
https://doi.org/10.1126/scisignal.2000287
https://doi.org/10.1126/scisignal.2000287