Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kai Su Greene"'
Autor:
Jing Wang, Xiangjin Zhuang, Kai Su Greene, Ha Si, Marc A. Antonyak, Joseph E. Druso, Kristin F. Wilson, Richard A. Cerione, Qiyu Feng, Hongyang Wang
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell communication in the tumour microenvironment. So far, the underlying mechanisms of MV biogenesis, especially how key tumorigenesis signals such as abnormal
Externí odkaz:
https://doaj.org/article/36e51596f90143b495d624b14b09205f
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destab
Externí odkaz:
https://doaj.org/article/0b1f4eac2a34411eb6e4e08a91e8e017
Autor:
Michael J. Lukey, Ahmad A. Cluntun, William P. Katt, Miao-chong J. Lin, Joseph E. Druso, Sekar Ramachandran, Jon W. Erickson, Henry H. Le, Zhihan-Emily Wang, Bryant Blank, Kai Su Greene, Richard A. Cerione
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 76-88.e7 (2019)
Summary: Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some context
Externí odkaz:
https://doaj.org/article/febd3a642aa746e1bfa7a9c5d1e5c5be
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to conf
Externí odkaz:
https://doaj.org/article/3b613416e0fb4b2589fd4ff157971900
Autor:
Wenchao Gu, Sijin Luozhong, Simian Cai, Ketaki Londhe, Nadine Elkasri, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Melissa Warden, Robert Langer, Shaoyi Jiang
Systemic delivery of mRNAs into disease neurons is first limited by the blood-brain-barrier (BBB). Leukocyte-derived extracellular vesicles (EVs) can cross the BBB at inflammatory sites, emerging as promising carriers to target the disease brain. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d704adad513c8f674f9615a7cb69a9b8
https://doi.org/10.1101/2022.12.07.518870
https://doi.org/10.1101/2022.12.07.518870
Autor:
Joseph E. Druso, B. Blank, Miao-chong J. Lin, Clint A. Stalnecker, Michael J. Lukey, Robert S. Weiss, Kai Su Greene, Xueying Wang, Richard A. Cerione, Chengliang Zhang, Kristin F. Wilson, Yashira L Negrón Abril, Hening Lin, Jon W. Erickson
Publikováno v:
Proc Natl Acad Sci U S A
Significance The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated in cancer cells, and a GLS-selective inhibitor is being evaluated in clinical trials. Previous screens identified succinylated lysine residues on GLS, but the function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7df8672282955596c45bf4d058b5742
https://doi.org/10.1073/pnas.1911954116
https://doi.org/10.1073/pnas.1911954116
Autor:
Richard A. Cerione, Hongyang Wang, Marc A. Antonyak, Kristin F. Wilson, Kai Su Greene, Xiangjin Zhuang, Jing Wang, Ha Si, Joseph E. Druso, Qiyu Feng
Publikováno v:
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 10, Iss 3, Pp n/a-n/a (2021)
Journal of Extracellular Vesicles, Vol 10, Iss 3, Pp n/a-n/a (2021)
Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell communication in the tumour microenvironment. So far, the underlying mechanisms of MV biogenesis, especially how key tumorigenesis signals such as abnormal EGF signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01d07c6832f9a5165886df1ceaa3aeb
https://pubmed.ncbi.nlm.nih.gov/33473262
https://pubmed.ncbi.nlm.nih.gov/33473262
Publikováno v:
Mol Cell Oncol
The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82312b694b3e6dbccc2863ef45068b8a
https://doi.org/10.1080/23723556.2020.1735284
https://doi.org/10.1080/23723556.2020.1735284
Autor:
Richard A. Cerione, William P. Katt, B. Blank, Miao-chong J. Lin, Sekar Ramachandran, Jon W. Erickson, Kai Su Greene, Ahmad A. Cluntun, Michael J. Lukey, Zhihan-Emily Wang, Henry H. Le, Joseph E. Druso
Publikováno v:
Cell reports
Cell Reports, Vol 29, Iss 1, Pp 76-88.e7 (2019)
Cell Reports, Vol 29, Iss 1, Pp 76-88.e7 (2019)
SUMMARY Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some contexts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a439e33eb1c7ddd3953860bcfc6801bf
https://doi.org/10.1016/j.celrep.2019.08.076
https://doi.org/10.1016/j.celrep.2019.08.076
Autor:
Kai Su Greene, Lukey, Michael J., Xueying Wang, Blank, Bryant, Druso, Joseph E., Lin, Miao-chong J., Stalnecker, Clint A., Zhang, Chengliang, Abril, Yashira Negrón, Erickson, Jon W., Wilson, Kristin F., Hening Lin, Weiss, Robert S., Cerione, Richard A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/26/2019, Vol. 116 Issue 52, p26625-26632, 8p