Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Kai SCHLEDZEWSKI"'
Autor:
Anna Sophia Jauch, Sebastian A. Wohlfeil, Céline Weller, Bianca Dietsch, Verena Häfele, Ana Stojanovic, Maximilian Kittel, Hendrik Nolte, Adelheid Cerwenka, Michael Neumaier, Kai Schledzewski, Carsten Sticht, Philipp-Sebastian Reiners-Koch, Sergij Goerdt, Cyrill Géraud
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding to hyaluronan, LYVE-1 can mediate adhesion of leukocytes and cancer cel
Externí odkaz:
https://doaj.org/article/7e8fd3d8dbfa4f958989dc52cbddebc7
Autor:
Sebastian A. Wohlfeil, Verena Häfele, Bianca Dietsch, Céline Weller, Carsten Sticht, Anna Sophia Jauch, Manuel Winkler, Christian David Schmid, Anna Lena Irkens, Ana Olsavszky, Kai Schledzewski, Philipp-Sebastian Reiners-Koch, Sergij Goerdt, Cyrill Géraud
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10–20% of stage 4 patients, came to the fore of melanoma research, as it recently evolved as d
Externí odkaz:
https://doaj.org/article/01d951e23b144140b8554b9e1c7d0db6
Autor:
Joschka Heil, Victor Olsavszky, Katrin Busch, Kay Klapproth, Carolina de la Torre, Carsten Sticht, Kajetan Sandorski, Johannes Hoffmann, Hiltrud Schönhaber, Johanna Zierow, Manuel Winkler, Christian David Schmid, Theresa Staniczek, Deborah E. Daniels, Jan Frayne, Georgia Metzgeroth, Daniel Nowak, Sven Schneider, Michael Neumaier, Vanessa Weyer, Christoph Groden, Hermann-Josef Gröne, Karsten Richter, Carolin Mogler, Makoto Mark Taketo, Kai Schledzewski, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Koch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre dri
Externí odkaz:
https://doaj.org/article/807900d34c274dcfa83939c240d17adf
Autor:
Philipp-Sebastian Koch, Kajetan Sandorski, Joschka Heil, Christian D. Schmid, Sina W. Kürschner, Johannes Hoffmann, Manuel Winkler, Theresa Staniczek, Carolina de la Torre, Carsten Sticht, Kai Schledzewski, Makoto Mark Taketo, Felix A. Trogisch, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Victor Olsavszky
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Endothelial wingless-related integration site (Wnt)-/β-catenin signaling is a key regulator of the tightly sealed blood–brain barrier. In the hepatic vascular niche angiokine-mediated Wnt signaling was recently identified as an important regulator
Externí odkaz:
https://doaj.org/article/1afabd3f26c04f1098bb660bad526b65
Autor:
Sergij Goerdt, Cyrill Géraud, Philipp-Sebastian Koch, Victor Olsavszky, Carsten Sticht, Joerg Heineke, Mona Malek Mohammadi, Thomas Leibing, Johanna Zierow, Manuel Winkler, Kai Schledzewski, Bianca Dietsch, Verena Häfele, Sebastian A. Wohlfeil
Additional information about the following materials and methods are enclosed here: Animal experiments, bioluminescence imaging, blood parameters, embryo and organ preparation, routine and immuno histology, microarray analysis, RNA in situ hybridizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2bcaf3fd5c31a22c68c6c2cd204e0a
https://doi.org/10.1158/0008-5472.22422647.v1
https://doi.org/10.1158/0008-5472.22422647.v1
Autor:
Sergij Goerdt, Cyrill Géraud, Philipp-Sebastian Koch, Victor Olsavszky, Carsten Sticht, Joerg Heineke, Mona Malek Mohammadi, Thomas Leibing, Johanna Zierow, Manuel Winkler, Kai Schledzewski, Bianca Dietsch, Verena Häfele, Sebastian A. Wohlfeil
These Tables provide primer sequences for qRT-PCR, show original data of immunofluorescence quantifications and extend the information about metastasis of WT31 melanoma cells to other organs than the liver.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001b15f736f39bd2cfc272e7677abbd6
https://doi.org/10.1158/0008-5472.22422638.v1
https://doi.org/10.1158/0008-5472.22422638.v1
Autor:
Sergij Goerdt, Cyrill Géraud, Philipp-Sebastian Koch, Victor Olsavszky, Carsten Sticht, Joerg Heineke, Mona Malek Mohammadi, Thomas Leibing, Johanna Zierow, Manuel Winkler, Kai Schledzewski, Bianca Dietsch, Verena Häfele, Sebastian A. Wohlfeil
The interaction of tumor cells with organ-specific endothelial cells (EC) is an important step during metastatic progression. Notch signaling in organ-specific niches has been implicated in mediating opposing effects on organotropic metastasis to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd8c1b7427046f1eed739b60c3345efe
https://doi.org/10.1158/0008-5472.c.6511292.v1
https://doi.org/10.1158/0008-5472.c.6511292.v1
Autor:
Sergij Goerdt, Cyrill Géraud, Philipp-Sebastian Koch, Victor Olsavszky, Carsten Sticht, Joerg Heineke, Mona Malek Mohammadi, Thomas Leibing, Johanna Zierow, Manuel Winkler, Kai Schledzewski, Bianca Dietsch, Verena Häfele, Sebastian A. Wohlfeil
These Figures contain an expression analysis of Clec4g in the mouse, detailed characterization of Clec4g eYFP reporter mice, detailed analysis of nEGFP expression in livers of NICDOE-HEC mice, further characterization of NICDOE-HEC mice and additiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2333e55c34dd855a1192fde87ff5e3
https://doi.org/10.1158/0008-5472.22422641
https://doi.org/10.1158/0008-5472.22422641
Autor:
Calin-Petru Manta, Thomas Leibing, Mirco Friedrich, Hendrik Nolte, Monica Adrian, Kai Schledzewski, Jessica Krzistetzko, Christof Kirkamm, Christian David Schmid, Yannick Xi, Ana Stojanovic, Sarah Tonack, Carolina de la Torre, Seddik Hammad, Stefan Offermanns, Marcus Krüger, Adelheid Cerwenka, Michael Platten, Sergij Goerdt, Cyrill Géraud
Publikováno v:
Circulation. 146(23)
BackgroundScavenger receptors (SR) Stabilin-1 (Stab1) and Stabilin-2 (Stab2) are preferentially expressed by liver sinusoidal endothelial cells. They mediate the clearance of circulating plasma molecules controlling distant organ homeostasis. Studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6d3af1512994cfb03b54b9e7842f62
https://pubmed.ncbi.nlm.nih.gov/36325910
https://pubmed.ncbi.nlm.nih.gov/36325910
Autor:
Carsten Sticht, Simon Anders, Gergana Dobreva, Alexey Uvarovskii, Manuel Winkler, Sina Wietje Kürschner, Michelle Neßling, Sergij Goerdt, Hiltrud Schönhaber, Theresa Staniczek, Arthur Mathes, Carolin Mogler, Daniel Hartmann, Julio Cordero, Christian Schmid, Philipp-Sebastian Koch, Linda Kessler, Cyrill Géraud, Guido von Figura, Kai Schledzewski, Xue-jun Zhang
Publikováno v:
Journal of Hepatology. 74:380-393
Background & Aims Angiocrine signaling by liver sinusoidal endothelial cells (LSECs) regulates hepatic functions such as growth, metabolic maturation, and regeneration. Recently, we identified GATA4 as the master regulator of LSEC specification durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771b6fb2d532be449fafa60eba9cf31f
https://doi.org/10.1016/j.jhep.2020.08.033
https://doi.org/10.1016/j.jhep.2020.08.033