Development of a human primary gut-on-a-chip to model inflammatory processes

Autor: Claudia Beaurivage, Auste Kanapeckaite, Cindy Loomans, Kai S. Erdmann, Jan Stallen, Richard A. J. Janssen

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)

Abstract Inflammatory bowel disease (IBD) is a complex multi-factorial disease for which physiologically relevant in vitro models are lacking. Existing models are often a compromise between biological relevance and scalability. Here, we integrated in

Externí odkaz: https://doaj.org/article/5ee09f4d5dd6420bbe0cfc533c9d9934

The binding affinity of PTPN13’s tandem PDZ2/3 domain is allosterically modulated

Autor: Markus Dicks, Gerd Kock, Bastian Kohl, Xueyin Zhong, Stefanie Pütz, Rolf Heumann, Kai S. Erdmann, Raphael Stoll

Publikováno v: BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-12 (2019)

Abstract Background Protein tyrosine phosphatase PTPN13, also known as PTP-BL in mice, is a large multi-domain non-transmembrane scaffolding protein with a molecular mass of 270 kDa. It is involved in the regulation of several cellular processes such

Externí odkaz: https://doaj.org/article/5b2a6bcbda254ecda2ff7021a1941f83

A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy

Autor: Sindhu Naik, Andrew R. Wood, Maté Ongenaert, Paniz Saidiyan, Edo D. Elstak, Henriëtte L. Lanz, Jan Stallen, Richard Janssen, Elizabeth Smythe, Kai S. Erdmann

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10, p 5361 (2021)

Lowe syndrome and Dent II disease are X-linked monogenetic diseases characterised by a renal reabsorption defect in the proximal tubules and caused by mutations in the OCRL gene, which codes for an inositol-5-phosphatase. The life expectancy of patie

Externí odkaz: https://doaj.org/article/b0fd7188d00e42bd8e7ba7895f271a6b

Development of a human primary gut-on-a-chip to model inflammatory processes

Autor: Auste Kanapeckaite, Claudia Beaurivage, Kai S. Erdmann, Cindy Loomans, Richard Antonius Jozef Janssen, Jan Stallen

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports

Inflammatory bowel disease (IBD) is a complex multi-factorial disease for which physiologically relevant in vitro models are lacking. Existing models are often a compromise between biological relevance and scalability. Here, we integrated intestinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e06b96b02f87796f67b210625a1d262
https://doaj.org/article/5ee09f4d5dd6420bbe0cfc533c9d9934

Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal

Autor: Elizabeth M. Manning, John-Paul Ashton, C. Henrique Alves, Jan Wijnholds, Mariyam Murtaza, Marysia Placzek, Andrew J.W. Furley, Kai S. Erdmann, Christopher J. Hill, Raman M. Das, P. Rashbass, Kavitha Chinnaiya, Nicholas Furley, Kate G. Storey, Christine M. Tait

Publikováno v: PLoS Biology, Vol 18, Iss 3, p e3000470 (2020)
Tait, C M, Chinnaiya, K, Manning, E, Murtaza, M, Ashton, J-P, Furley, N, Hill, C J, Alves, C H, Wijnholds, J, Erdmann, K S, Furley, A, Rashbass, P, Das, R M, Storey, K G & Placzek, M 2020, ' Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal ', PLoS Biology, vol. 18, no. 3, pp. e3000470 . https://doi.org/10.1371/journal.pbio.3000470
PLoS Biology, 18(3). PUBLIC LIBRARY SCIENCE
PLoS Biology, 18(3). Public Library of Science
PLoS Biology

In the spinal cord, the central canal forms through a poorly understood process termed dorsal collapse that involves attrition and remodelling of pseudostratified ventricular layer (VL) cells. Here, we use mouse and chick models to show that dorsal v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93389b2670d77d7bbc36c562d9d47228
https://doaj.org/article/f8b3e06e128a4e3d929b8ac00ab8d735