Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kai S, Lipinski"'
Autor:
Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Tomas Becvar, Patrick Lypaczewski, Eli Schwartz, Elizabeth Greensted, Katrien Van Bocxlaer, Marion Pasin, Kai S. Lipinski, Vivak Parkash, Greg Matlashewski, Alison M. Layton, Charles J. Lacey, Charles L. Jaffe, Petr Volf, Paul M. Kaye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Controlled human infection models (CHIMs) provide a pathway for accelerating vaccine development. Here, the authors describe the isolation, characterization, and GMP manufacture of a clinical Leishmania major strain to be used as a resource for CHIM
Externí odkaz:
https://doaj.org/article/ddd377d986694040985714870d5c4e1c
Autor:
Elizabeth Greensted, Paul M. Kaye, Petr Volf, Helen Ashwin, Eli Schwartz, Barbora Vojtkova, Charles J.N. Lacey, Marion Pasin, Tomas Becvar, Alison M. Layton, Kai S. Lipinski, Greg Matlashewski, Vivak Parkash, Charles L. Jaffe, Patrick Lypaczewski, Katrien Van Bocxlaer, Jovana Sadlova
Leishmaniasis is widely regarded as a vaccine-preventable disease, but the costs required to reach pivotal Phase 3 studies and uncertainty about which candidate vaccines should be progressed into human studies significantly limits progress in vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26829e33325cdfe420eb15ac1b434281
https://doi.org/10.1101/2020.08.12.245936
https://doi.org/10.1101/2020.08.12.245936
Autor:
Petra Forgách, Attila Farsang, Ernő Horváth, Kai S. Lipinski, Ákos Hornyák, Tibor Bakács, Tamás Bakonyi, Vilmos Palya, Susan J. Hedley, Imre Kovesdi
Publikováno v:
The Journal of Gene Medicine. 17:116-131
Background Despite spectacular successes in hepatitis B and C therapies, severe hepatic impairment is still a major treatment problem. The clinically tested infectious bursal disease virus (IBDV) superinfection therapy promises an innovative, interfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be782ad317955d4b1bad3300c165fa8f
https://doi.org/10.1002/jgm.2830
https://doi.org/10.1002/jgm.2830
Publikováno v:
The Journal of Gene Medicine. 9:639-648
Background Predictable and adequate transgene expression is essential for clinical gene therapy. Several studies have focused on optimization of transgene expression. In this study the effect of sodium butyrate (NaB) and a ubiquitous chromatin openin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679f851d2b9e86cae2f8a9220332015b
https://doi.org/10.1002/jgm.1057
https://doi.org/10.1002/jgm.1057
Autor:
Stephen Todryk, Chris H. Bangma, Alistair Simpson Irvine, Robert Kraaij, Kingston H. G. Mills, Kai S. Lipinski, Andrew Mountain, Steven Pelech
Publikováno v:
Cancer Immunology, Immunotherapy. 55:347-354
Gene-directed enzyme-prodrug therapy (GDEPT) using nitroreductase (NTR), with efficient adenoviral delivery, and CB1954 (CB), is an effective means of directly killing tumours. However, an immune-mediated bystander effect remains an important product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d8d7ef1c4a8c2656ecad724b5158e0
https://doi.org/10.1007/s00262-005-0014-9
https://doi.org/10.1007/s00262-005-0014-9
Autor:
Ákos, Hornyák, Kai S, Lipinski, Tamás, Bakonyi, Petra, Forgách, Ernő, Horváth, Attila, Farsang, Susan J, Hedley, Vilmos, Palya, Tibor, Bakács, Imre, Kovesdi
Publikováno v:
The journal of gene medicine. 17(6-7)
Despite spectacular successes in hepatitis B and C therapies, severe hepatic impairment is still a major treatment problem. The clinically tested infectious bursal disease virus (IBDV) superinfection therapy promises an innovative, interferon-free so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a645dea158994063a267b25f18aacf8
https://pubmed.ncbi.nlm.nih.gov/25929556
https://pubmed.ncbi.nlm.nih.gov/25929556
Autor:
A.Hakim Djeha, Tariq Ismail, Andrew Mountain, Christopher J. Wrighton, Lawrence S. Young, Kai S. Lipinski
Publikováno v:
Molecular Therapy. 4:365-371
There is an urgent need for improved therapies for inoperable metastatic colon cancer. Gene-directed enzyme prodrug therapy (GDEPT) using adenovirus vectors works well in preclinical models of this disease, but successful clinical application is hamp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6544da730ea7d4ea8ee309176df9ec66
https://doi.org/10.1006/mthe.2001.0468
https://doi.org/10.1006/mthe.2001.0468
Publikováno v:
Journal of Biological Chemistry. 275:8911-8920
Expression of the transcription unit early region 2 (E2) is of crucial importance for adenoviruses because this region encodes proteins essential for viral replication. Here, we demonstrate that the E1A(12S) protein of the oncogenic adenovirus seroty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f152a7ee60662b57958e304bb7c193
https://doi.org/10.1074/jbc.275.12.8911
https://doi.org/10.1074/jbc.275.12.8911
Publikováno v:
Virology. 255:94-105
Association with the cellular coactivators p300 and CBP is required for the growth-regulatory function of adenoviral (Ad) early region 1A (E1A) proteins. E1A regions necessary for these interactions overlap with domains involved in the induction of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977ff45d03a961c239cec8814814a76f
https://doi.org/10.1006/viro.1998.9583
https://doi.org/10.1006/viro.1998.9583
Publikováno v:
Virus Research. 54:99-106
Early region 1A (E1A) gene products of adenoviruses (Ad) play an essential role in both productive infection and cellular transformation. Besides their function to induce the expression of all other adenoviral genes they modulate the expression of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62f505fd86dd9417141a2bada735505
https://doi.org/10.1016/s0168-1702(98)00003-3
https://doi.org/10.1016/s0168-1702(98)00003-3