Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kai R. Sterz"'
Autor:
Fabian Giehler, Michael S. Ostertag, Thomas Sommermann, Daniel Weidl, Kai R. Sterz, Helmut Kutz, Andreas Moosmann, Stephan M. Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz M. Popowicz, Johannes Kirchmair, Arnd Kieser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1’s transforming activity depends on its C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engaging TNF
Externí odkaz:
https://doaj.org/article/6129e63ef175431f88dcfe4bca0f1328
Autor:
Stefanie Voigt, Kai R. Sterz, Fabian Giehler, Anne-Wiebe Mohr, Joanna B. Wilson, Andreas Moosmann, Arnd Kieser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
IKK2 is the main mediator of the NF-kappaB pathway. Here, the authors demonstrate that LMP1 sustains the survival of Epstein-Barr virus-transformed human B cells and post-transplant lymphoma through IKK2 that induces JNK signaling through TPL2.
Externí odkaz:
https://doaj.org/article/a2305298494b481ca6cef8d55610d0b9
Autor:
Anne-Wiebe Mohr, Arnd Kieser, Joanna B. Wilson, Andreas Moosmann, Stefanie Voigt, Fabian Giehler, Kai R. Sterz
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nat. Commun. 11:685 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nat. Commun. 11:685 (2020)
IκB kinase 2 (IKK2) is well known for its pivotal role as a mediator of the canonical NF-κB pathway, which has important functions in inflammation and immunity, but also in cancer. Here we identify a novel and critical function of IKK2 and its co-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254d2635c26d127486aab161413a5994
https://eprints.gla.ac.uk/210507/1/210507.pdf
https://eprints.gla.ac.uk/210507/1/210507.pdf
Autor:
Arnd, Kieser, Kai R, Sterz
Publikováno v:
Current topics in microbiology and immunology. 391
Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized as the primary transforming gene product of the virus. LMP1 is expressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5fd110bea27550562bc4387ac62155b
https://pubmed.ncbi.nlm.nih.gov/26428373
https://pubmed.ncbi.nlm.nih.gov/26428373
Autor:
Kai R. Sterz, Arnd Kieser
Publikováno v:
Epstein Barr Virus Volume 2 ISBN: 9783319228334
Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized as the primary transforming gene product of the virus. LMP1 is expressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac08adcd03ca3f70461538da3040c185
https://doi.org/10.1007/978-3-319-22834-1_4
https://doi.org/10.1007/978-3-319-22834-1_4