Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kai Pollard"'
Autor:
Jamie L. Grit, Benjamin K. Johnson, Patrick S. Dischinger, Curt J. Essenburg, Marie Adams, Stacy Campbell, Kai Pollard, Christine A. Pratilas, Tim J. Triche, Carrie R. Graveel, Matthew R. Steensma
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share nearly identical histology, but
Externí odkaz:
https://doaj.org/article/b57ae06c37da44ceb7d75cf5e63ae1e7
Autor:
Austin K Mattox, Christopher Douville, Natalie Silliman, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Maria Popoli, Cherie Blair, Kathy Judge, Kai Pollard, Christine Pratilas, Jaishri Blakeley, Fausto Rodriguez, Nickolas Papadopoulos, Allan Belzberg, Chetan Bettegowda
Publikováno v:
eLife, Vol 11 (2022)
Malignant peripheral nerve sheath tumors (MPNST) are the deadliest cancer that arises in individuals diagnosed with neurofibromatosis and account for nearly 5% of the 15,000 soft tissue sarcomas diagnosed in the United States each year. Comprised of
Externí odkaz:
https://doaj.org/article/5f4eeb9527be4d2ea6e9da2d44488190
Autor:
Carina Dehner, Chang In Moon, Xiyuan Zhang, Zhaohe Zhou, Chris Miller, Hua Xu, Xiaodan Wan, Kuangying Yang, Jay Mashl, Sara J.C. Gosline, Yuxi Wang, Xiaochun Zhang, Abigail Godec, Paul A. Jones, Sonika Dahiya, Himanshi Bhatia, Tina Primeau, Shunqiang Li, Kai Pollard, Fausto J. Rodriguez, Li Ding, Christine A. Pratilas, Jack F. Shern, Angela C. Hirbe
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
One of the most common malignancies affecting adults with Neurofibromatosis type 1 (NF1) is the malignant peripheral nerve sheath tumor (MPNST), an aggressive and often fatal sarcoma that commonly arises from benign plexiform neurofibromas. Despite a
Externí odkaz:
https://doaj.org/article/02174fc3c80343d29dc12bc04c3f1439
Autor:
Dana C. Borcherding, Neha V. Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A. Pratilas, Kai Pollard, Taylor Sundby, Brigitte C. Widemann, Angela C. Hirbe
Publikováno v:
Clinical Cancer Research. 29:1592-1604
Purpose: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6376177010a995b701dd6baf6516d887
https://doi.org/10.1158/1078-0432.ccr-22-3722
https://doi.org/10.1158/1078-0432.ccr-22-3722
Autor:
Alex T Larsson, Himanshi Bhatia, Ana Calizo, Kai Pollard, Xiaochun Zhang, Eric Conniff, Justin F Tibbitts, Elizabeth Rono, Katherine Cummins, Sara H Osum, Kyle B Williams, Alexandra L Crampton, Tyler Jubenville, Daniel Schefer, Kuangying Yang, Yang Lyu, James C Pino, Jessica Bade, John M Gross, Alla Lisok, Carina A Dehner, John S A Chrisinger, Kevin He, Sara J C Gosline, Christine A Pratilas, David A Largaespada, David K Wood, Angela C Hirbe
Publikováno v:
Neuro-Oncology.
Background Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1). To address the critical need for novel therapeutics in MPNST, we aimed to establish an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6039c6fd8a56c7fa88ceae08ddd8c926
https://doi.org/10.1093/neuonc/noad097
https://doi.org/10.1093/neuonc/noad097
Autor:
Ina Ly, Tianyu Liu, Wenli Cai, Olivia Michaels, Maya Viera, Daniel Kwon, Miriam Bredella, Justin Jordan, Dana Borcherding, Demetrius Boswell, Crystal Burgess, Ping Chi, Peter de Blank, Eva Dombi, Angela Hirbe, Bruce Korf, Shernine Lee, Victor Mautner, Mairim Melecio-Vazquez, Zachary Mulder, Kai Pollard, Christine Pratilas, Johannes Salamon, Divya Srihari, Matthew Steensma, Brigitte Widemann, Jaishri Blakeley, Scott Plotkin
Publikováno v:
Monday, April 24.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0996e7f9d16851b200479fdafbed31ba
https://doi.org/10.1212/wnl.0000000000203702
https://doi.org/10.1212/wnl.0000000000203702
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplemental Fig.S5. Validation of select gene expression changes with TYK2 inhibitor treatment that were identified by qPCR array. JH-2-002 cells were incubated with 40 µMWU-12 or control for 48 hours, and gene expression was analyzed by qPCR for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9731d69082d42fc007e50b47eee746df
https://doi.org/10.1158/1078-0432.22632929
https://doi.org/10.1158/1078-0432.22632929
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Purpose:Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8930420b460dd667c263399c108f1bcc
https://doi.org/10.1158/1078-0432.c.6533056
https://doi.org/10.1158/1078-0432.c.6533056
Autor:
Angela C. Hirbe, Brigitte C. Widemann, Taylor Sundby, Kai Pollard, Christine A. Pratilas, Peter Ruminski, Layla Daud, Angad Gothra, Himanshi Bhatia, Carina Dehner, Yang Lyu, Xiaochun Zhang, Kevin He, Neha V. Amin, Dana C. Borcherding
Supplementary Table S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abab81da46462cc6120854cc7d2ae2bf
https://doi.org/10.1158/1078-0432.22632908.v1
https://doi.org/10.1158/1078-0432.22632908.v1
Supplementary Table S2 shows a summary report for targeted gene sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa339cc43b944db57fda296bde46a95
https://doi.org/10.1158/0008-5472.22427170.v1
https://doi.org/10.1158/0008-5472.22427170.v1