Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kai Ping Sem"'
Autor:
Shiqi Zhong, Raphael Chèvre, David Castaño Mayan, Maria Corlianò, Blake J. Cochran, Kai Ping Sem, Theo H. van Dijk, Jianhe Peng, Liang Juin Tan, Siddesh V. Hartimath, Boominathan Ramasamy, Peter Cheng, Albert K. Groen, Folkert Kuipers, Julian L. Goggi, Chester Drum, Rob M. van Dam, Ru San Tan, Kerry-Anne Rye, Michael R. Hayden, Ching-Yu Cheng, Shaji Chacko, Jason Flannick, Xueling Sim, Hong Chang Tan, Roshni R. Singaraja
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
BACKGROUND Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans.METHODS To determine whether reduced CYP8B1 activity improves insulin sensitivity, we
Externí odkaz:
https://doaj.org/article/d03f46bd050f440897a9444be497521e
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16603 (2011)
Adenomatous Polyposis Coli (APC) is a tumor suppressor gene product involved in colon cancer. APC is a large multidomain molecule of 2843 amino acid residues and connects cell-cell adhesion, the F-actin/microtubule cytoskeleton and the nucleus. Here
Externí odkaz:
https://doaj.org/article/da9ee3a99ccc4ce5a0bd5d570a275665
Autor:
Vera F. Monteiro-Cardoso, Xin Yi Yeo, Han-Gyu Bae, David Castano Mayan, Mariam Wehbe, Sejin Lee, Kumar Krishna-K, Seung Hyun Baek, Leon F. Palomera, Sangeetha Shanmugam, Kai Ping Sem, Matthew P. Parsons, Michael R. Hayden, Elisa A. Liehn, Sreedharan Sajikumar, Svend Davanger, Dong-Gyu Jo, Sangyong Jung, Roshni R. Singaraja
BackgroundBile acids (BAs), which act in the liver-brain axis, are liver-derived signaling molecules found in the brain. However, how they modulate neurological function remains largely unknown.MethodsTo assess the role of BAs in the brain, we genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6c0e02e9736edd5a1329e26b917c7d7
https://doi.org/10.1101/2022.12.11.520005
https://doi.org/10.1101/2022.12.11.520005
Publikováno v:
Scientific Reports
The insulin receptor substrate of 53 kDa, IRSp53, is an adaptor protein that works with activated GTPases, Cdc42 and Rac, to modulate actin dynamics and generate membrane protrusions in response to cell signaling. Adult mice that lack IRSp53 fail to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebd7a98b0e60523f2870de167bd3829
https://pubmed.ncbi.nlm.nih.gov/28067313
https://pubmed.ncbi.nlm.nih.gov/28067313
Autor:
Ai Mei Chou, Thankiah Sudhaharan, Kai Ping Sem, Yuan Hong Yu, Sohail Ahmed, Wah Ing Goh, Hwi Fen Liew
Publikováno v:
Journal of Cell Science.
Rif induces dorsal filopodia but the signaling pathway responsible for this has not been identified. We show here that Rif interacts with the I-BAR family protein IRTKS (also known as BAIAP2L1) through its I-BAR domain. Rif also interacts with Pinkba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4914d8da69f412887726696155db6c38
https://doi.org/10.1242/jcs.179655
https://doi.org/10.1242/jcs.179655
Filopodia are dynamic actin-based structures that play roles in processes such as cell migration, wound healing, and axonal guidance. Cdc42 induces filopodial formation through IRSp53, an Inverse-Bin-Amphiphysins-Rvs (I-BAR) domain protein. Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b574f1ed232acacade941493f90efe71
https://europepmc.org/articles/PMC4148866/
https://europepmc.org/articles/PMC4148866/
Publikováno v:
Journal of Cell Science. 112:1225-1235
During Drosophila embryogenesis the two halves of the lateral epidermis migrate dorsally over a surface of flattened cells, the amnioserosa, and meet at the dorsal midline in order to form the continuous sheet of the larval epidermis. During this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8320b9d3ba5499bf83ba5dc8208262e7
https://doi.org/10.1242/jcs.112.8.1225
https://doi.org/10.1242/jcs.112.8.1225
Autor:
Ai Mei Chou, Thankiah Sudhaharan, Wenyu Bu, Wah Ing Goh, Kim Buay Lim, Sohail Ahmed, Kai Ping Sem
Filopodia are dynamic actin-rich cell surface protrusions involved in cell migration, axon guidance, and wound healing. The RhoGTPase Cdc42 generates filopodia via IRSp53, a multidomain protein that links the processes of plasma membrane deformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5031ea019b1ba61d31848862d7d1337
https://europepmc.org/articles/PMC3281667/
https://europepmc.org/articles/PMC3281667/
Filopodia are cellular protrusions important for axon guidance, embryonic development, and wound healing. The Rho GTPase Cdc42 is the best studied inducer of filopodium formation, and several of its effectors and their interacting partners have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da2d3af11f90e7941ca034e6a45aaa
https://europepmc.org/articles/PMC3075712/
https://europepmc.org/articles/PMC3075712/
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e16603 (2011)
PLoS ONE, Vol 6, Iss 2, p e16603 (2011)
Adenomatous Polyposis Coli (APC) is a tumor suppressor gene product involved in colon cancer. APC is a large multidomain molecule of 2843 amino acid residues and connects cell-cell adhesion, the F-actin/microtubule cytoskeleton and the nucleus. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d277061c2f0a86e7733efc5a178b82df
https://pubmed.ncbi.nlm.nih.gov/21311754
https://pubmed.ncbi.nlm.nih.gov/21311754