Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kai P. Yuet"'
Autor:
Kai P. Yuet, Chaitan Khosla
Publikováno v:
Metabolic Engineering Communications, Vol 10, Iss , Pp e00106- (2020)
Assembly-line polyketide synthases generate natural products that have led to many live-saving drugs. The use of E. coli as a heterologous host for reconstituting these enormous and complex enzymatic machines has and will continue to be a critical st
Externí odkaz:
https://doaj.org/article/f0111dc59b974098ab156f3a389d847d
Publikováno v:
J Org Chem
Notwithstanding the "one-module-one-elongation-cycle" paradigm of assembly line polyketide synthases (PKSs), some PKSs harbor modules that iteratively elongate their substrates through a defined number of cycles. While some insights into module itera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acb8d6cefae981d5897f962519d93a4
https://doi.org/10.1021/acs.joc.1c00120
https://doi.org/10.1021/acs.joc.1c00120
Publikováno v:
Chemical Reviews. 119:12524-12547
Assembly-line polyketide synthases (PKSs) are among the most complex protein machineries known in nature, responsible for the biosynthesis of numerous compounds used in the clinic. Their present-day diversity is the result of an evolutionary path tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea9f85baea9572529e807211f4e4eb09
https://doi.org/10.1021/acs.chemrev.9b00525
https://doi.org/10.1021/acs.chemrev.9b00525
Notwithstanding the “one-module-one-elongation-cycle” paradigm of assembly line polyketide synthases (PKSs), some PKSs harbor modules that iteratively elongate their substrates through a defined number of cycles. While some insights into module i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edf5ffcd4a9c1ae01df8087a90556e50
https://doi.org/10.1101/2021.01.15.426894
https://doi.org/10.1101/2021.01.15.426894
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential ingredients of the human diet. They are synthesized by LC-PUFA synthases (PFASs) expressed in marine bacteria and other organisms. PFASs are large enzyme complexes that are homologous to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e543ac5bc65ce6098205d49dc815a6
https://pubmed.ncbi.nlm.nih.gov/33283513
https://pubmed.ncbi.nlm.nih.gov/33283513
Autor:
Chaitan Khosla, Kai P. Yuet
Publikováno v:
Metabolic Engineering Communications, Vol 10, Iss, Pp e00106-(2020)
Assembly-line polyketide synthases generate natural products that have led to many live-saving drugs. The use of E. coli as a heterologous host for reconstituting these enormous and complex enzymatic machines has and will continue to be a critical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a7d7098d00893dd235656627e7a53a
http://www.sciencedirect.com/science/article/pii/S2214030119300379
http://www.sciencedirect.com/science/article/pii/S2214030119300379
Autor:
James Kuo, Robert B. Lee, Wesley Michaels, Chun Liu, Curt R. Fischer, Chaitan Khosla, Brian L. Zhong, Abigail E. McShane, Kai P. Yuet, Stephen R. Lynch
Publikováno v:
J Am Chem Soc
Several Nocardia strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly line polyketide synthase (PKS) that presumably synthesizes an unknown polyketide. Here, we report the discovery and structure e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b58acac0a145956dfa79d49d024e48
https://europepmc.org/articles/PMC7329362/
https://europepmc.org/articles/PMC7329362/
Autor:
Wesley Michaels, Kai P. Yuet, Chaitan Khosla, Lynch, Chun Liu, Brian L. Zhong, Curt R. Fischer, James Kuo, Abigail E. McShane, Robert B. Lee
Several Nocardia strains associated with nocardiosis, a potentially life-threatening disease, house a nonamodular assembly-line polyketide synthase (PKS) that presumably synthesizes an unknown natural product. Here, we report the discovery and struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ea952b8227632c99c3c08b9296d73
https://doi.org/10.1101/2020.01.28.923383
https://doi.org/10.1101/2020.01.28.923383
Publikováno v:
Chemical reviews. 119(24)
[Image: see text] Assembly-line polyketide synthases (PKSs) are among the most complex protein machineries known in nature, responsible for the biosynthesis of numerous compounds used in the clinic. Their present-day diversity is the result of an evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fde27b975c7a4f47a079ec08b7102a5
https://pubmed.ncbi.nlm.nih.gov/31838842
https://pubmed.ncbi.nlm.nih.gov/31838842
Autor:
Kai P, Yuet, Chaitan, Khosla
Publikováno v:
Metabolic Engineering Communications
Assembly-line polyketide synthases generate natural products that have led to many live-saving drugs. The use of E. coli as a heterologous host for reconstituting these enormous and complex enzymatic machines has and will continue to be a critical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::996709d300400f66c1ee4758ab008a31
https://pubmed.ncbi.nlm.nih.gov/32547924
https://pubmed.ncbi.nlm.nih.gov/32547924