A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients

Autor: Sebastian Toncar, Thomas Schmiedeke, Thomas Vogl, Nils Pollak, Michael Leidig, Beatrix Büschges-Seraphin, Marianne Kleinert, Cord Schneuzer, Christina Klaeffling, Clemens Grupp, Christoph Blaser, Susanne Berweck, Rüdiger Götz, Stefan Fischer, Andreas Schmitt, Bettina Wirth, Frank Breunig, Markus Ketteler, Hendrick Witsch, Frank Strutz, Uwe Malzahn, Oliver Jung, Markus Schneider, Julian Gebhardt, Jan Goßmann, Mohamed Marwan, Holger Naujoks, Mara Dörken, L. Schramm, Ewelina Sobkowiak, Michael Heckel, Joanna Harazny, Arnfried Klingbeil, J Zimmermann, Maria Moritz, Heribert Fink, Raoul Zeltner, Patrick Biggar, Rolf Janka, Ahmet Cakmak, Stefan Büttner, Christoph Betz, Fabian Hammer, Heike Schneider, Sarah Rudolf, Beate Schamberger, Imke Reimer, Claudius Kleinert, Michael Brunner, Sabine Schütterle, Susanne Schwedler, Vera Krane, Thorsten Klink, Sophie Richter, Christian Ritter, Markus Schöffauer, Tilo Freiwald, Helmut Geiger, Ulrike Raff, Benjamin-Florian Koch, Renate Hammerstingl, Thomas Bochannek, Joachim Hoyer, Wolfgang Freisinger, Paul Würmell, Daniel Sollinger, Vladimir Vasiljuk, Michael Schmid, Clemens Reichert, Jens Lutz, Stefan Störk, Reinhard Schneider, Andrea Heyd-Schramm, Thomas Döltz, Brigitte Moye, Kai-Olaf Netzer, Kai-Uwe Eckardt, Jurij Ribel, Christoph Wanner, Julian Donhauser, Thorsten Walther, Julia Weinmann-Menke, Judith Kosowski

Publikováno v: Kidney International. 95:983-991

Mineralocorticoid receptor antagonists have beneficial effects on left ventricular remodeling, cardiac fibrosis, and arrhythmia in heart failure, but efficacy and safety in dialysis patients is less clear. We evaluated the effect of spironolactone on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc8f0e24798b6d023a9deb6f47218d3
https://doi.org/10.1016/j.kint.2018.11.025

Meta-analysis of genotype-phenotype correlation in X-linked Alport syndrome: impact on clinical counselling

Autor: Manfred Weber, Stefan Seibold, Kai-Olaf Netzer, Oliver Gross, Romy Lambrecht

Publikováno v: Nephrology Dialysis Transplantation. 17:1218-1227

Background. Alport syndrome (AS) is a hereditary nephropathy characterized by progressive renal failure, hearing loss and ocular lesions. Numerous mutations of the COL4A5 gene encoding the a5-chain of type IV collagen have been described, establishin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6680c83f5548584d305a3f82db9d3d22
https://doi.org/10.1093/ndt/17.7.1218

Type IV Collagen of the Glomerular Basement Membrane

Autor: Sripad Gunwar, Milton E. Noelken, Billy G. Hudson, Olga Bondar, Kai-Olaf Netzer, Yoshifumi Ninomiya, Yoshikazu Sado, Dorin-Bogdan Borza, Narinder Singh, Ariel Boutaud

Publikováno v: Journal of Biological Chemistry. 275:30716-30724

The ultrafiltration function of the glomerular basement membrane (GBM) of the kidney is impaired in genetic and acquired diseases that affect type IV collagen. The GBM is composed of five (alpha1 to alpha5) of the six chains of type IV collagen, orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8001a0ad7b9452d1a7088fb48de7316
https://doi.org/10.1074/jbc.m004569200

The Goodpasture Autoantigen

Autor: Anu Leinonen, Juan Saus, Dorin-Bogdan Borza, Parvin Todd, Kai-Olaf Netzer, Billy G. Hudson, Javier Cervera

Publikováno v: Journal of Biological Chemistry. 275:6030-6037

Goodpasture (GP) disease is an autoimmune disorder in which autoantibodies against the α3(IV) chain of type IV collagen bind to the glomerular and alveolar basement membranes, causing progressive glomerulonephritis and pulmonary hemorrhage. Two majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4624c1e9913fd38af45d9351883a23ea
https://doi.org/10.1074/jbc.275.8.6030

Goodpasture antigen: Expression of the full-length α3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain

Autor: Kai-Olaf Netzer, Sripad Gunwar, Anu Leinonen, Ariel Boutaud, Billy G. Hudson

Publikováno v: Kidney International. 55:926-935

Goodpasture antigen: Expression of the full-length α3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain. Background Tissue injury in Goodpasture (GP) syndrome (rapidly progressive glomerular nephritis and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9701799bc7ed0747b7d0e53880ac3f5
https://doi.org/10.1046/j.1523-1755.1999.055003926.x