Výsledky vyhledávání - "Kai O. Reynhardt"

Prediction of clinical pharmacokinetics of AMG 181, a human anti-α4β7 monoclonal antibody for treating inflammatory bowel diseases

Autor: John A. Wisler, Peter J. Prince, Kathleen Köck, Hailing Hsu, Kai O. Reynhardt, Wei-Jian Pan, Dominic C. Borie, William A. Rees, Zhigang Yu, Hong Li, David H. Salinger

Publikováno v: Pharmacology Research & Perspectives

The purpose of this study was to predict a safe starting dose of AMG 181, a human anti-α 4 β 7 antibody for treating inflammatory bowel diseases, based on cynomolgus monkey pharmacokinetic (PK) and pharmacodynamic (PD) data. A two-compartment model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7681a5910c5d5de36930954856ae429d
http://europepmc.org/articles/PMC4317229

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Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody

Autor: Dan A. Rock, Wei-Jian Pan, Michael J. Santostefano, Hugo M. Vargas, James F. Reindel, Duc Tran, Madeline M. Fort, Kai O. Reynhardt, Jacqueline A. Kirchner, Padma K. Narayanan, Remi Jawando, William A. Rees, Nancy E. Everds, Peter J. Prince, Sean Lear, Kelly Hensley, Christine Vissinga

Publikováno v: Toxicologic pathology. 40(6)

AMG X, a human neutralizing monoclonal antibody (mAb) against a soluble human protein, caused thrombocytopenia, platelet activation, reduced mean arterial pressure, and transient loss of consciousness in cynomolgus monkeys after first intravenous adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b455e0b072e4e10b74933b0f1af8bc
https://pubmed.ncbi.nlm.nih.gov/22552394

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Sa1206 Multiple-Dose Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of AMG 181, a Human Anti-a4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD)

Autor: Wei-Jian Pan, Zhigang Yu, Mark Yen, Christine M. Evangelista, Jonathan Lee, Barbara A. Sullivan, Kefei Zhou, Peter J. Prince, Kai O. Reynhardt, Dominique C. Borie, Hailing Hsu, William A. Rees, Michele M. Hooper, David R. Doherty

Publikováno v: Gastroenterology. 144:S-229

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28b890aa86fec3a222f37cdbbbdbf942
https://doi.org/10.1016/s0016-5085(13)60812-4

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Sa1207 Pharmacokinetics/Pharmacodynamics (PK/PD), Efficacy, and Safety of AMG 181 in Subjects With Active, Mild to Moderate Ulcerative Colitis - An Initial Assessment

Autor: Jonathan Lee, Barbara A. Sullivan, Kai O. Reynhardt, Christine M. Evangelista, David R. Doherty, Graham L. Radford-Smith, Jane M. Andrews, Dominique C. Borie, Peter J. Prince, Justo Sierra Johnson, William A. Rees, Wei-Jian Pan, Zhigang Yu, Howard Schwartz, Anthony M. Treacy, Kefei Zhou

Publikováno v: Gastroenterology. 144:S-230

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b45734e44cee8458eead3eeeb147c9be
https://doi.org/10.1016/s0016-5085(13)60813-6

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Su2082 Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Amg 181, a Fully Human Anti-α4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD)

Autor: Dominique C. Borie, Kai O. Reynhardt, Christine M. Evangelista, Susanna Dodson, Kefei Zhou, Larry C. Wienkers, William A. Rees, Peter J. Prince, Mark Yen, Sonal K. Patel, Christine A. Haller, Chi-Yan J. Tam, Hailing Hsu, David R. Doherty, Wei-Jian Pan, Zhigang Yu, Wen Gu, Barbara A. Sullivan

Publikováno v: Gastroenterology. 142:S-565

Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Amg 181, a Fully Human Anti-α4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD) Wei-Jian Pan, Barbara A. Sullivan, Christine M. Evangelista, David R. Doherty, Chi-Yan J. Tam, Sona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b4cad06d03e53cc9beaa25372f13fac
https://doi.org/10.1016/s0016-5085(12)62170-2

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