Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kai N. Sands"'
Publikováno v:
Molecules, Vol 28, Iss 9, p 3732 (2023)
The antioxidant drug ebselen has been widely studied in both laboratories and in clinical trials. The catalytic mechanism by which it destroys hydrogen peroxide via reduction with glutathione or other thiols is complex and has been the subject of con
Externí odkaz:
https://doaj.org/article/d726cc81c19e45ccb1f7d1d4390301f2
Publikováno v:
Angewandte Chemie International Edition. 61
During attempts to prepare spirodithiaselenuranes as GPx mimetics, a series of unexpected dimeric macrocycles was obtained, each containing two selenide and two disulfide moieties in rings ranging from 18- to 26-membered. The products showed potent G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d8f1c859946d2469c9b8c7c3ee8293
https://doi.org/10.1002/anie.202213744
https://doi.org/10.1002/anie.202213744
Publikováno v:
The Journal of Organic Chemistry. 86:9938-9944
The synthesis of aryl selenonic acids was achieved from diverse aryl bromides via a one-pot method involving metalation, selenation, and oxidation with hydrogen peroxide followed by ion exchange to afford the pure products in 77-90% yield. An o-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98aa50c9d4dde0220b5e2eaee0f585e7
https://doi.org/10.1021/acs.joc.1c01369
https://doi.org/10.1021/acs.joc.1c01369
Autor:
Thomas G. Back, Benjamin S. Gelfand, Graham N. George, Kai N. Sands, Emerita Mendoza Rengifo, Ingrid J. Pickering
Publikováno v:
Angewandte Chemie. 132:4313-4317
Benzeneperoxyseleninic acid has been proposed as the key intermediate in the widely used epoxidation of alkenes with benzeneseleninic acid and hydrogen peroxide. However, it reacts sluggishly with cyclooctene and instead rapidly decomposes in solutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61265f12c32fae0e86d6aebb28c35f9d
https://doi.org/10.1002/ange.201913566
https://doi.org/10.1002/ange.201913566
Autor:
Kai N. Sands, Thomas G. Back
Publikováno v:
Tetrahedron. 74:4959-4967
Hydrogen peroxide and lipid hydroperoxides are formed during aerobic metabolism and contribute to oxidative stress, a major factor in many diseases and degenerative conditions. Although the selenoenzyme glutathione peroxidase (GPx) affords antioxidan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0d4d9ecb09939324f4b4c196f97a9b3
https://doi.org/10.1016/j.tet.2018.05.027
https://doi.org/10.1016/j.tet.2018.05.027
Publikováno v:
Chemistry - A European Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::997b57347546d80599f82637b814313a
https://doi.org/10.1002/chem.201883962
https://doi.org/10.1002/chem.201883962
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(39)
Selenium compounds play an important role in redox homeostasis in living organisms. One of their major functions is to suppress the harmful effects of hydrogen peroxide, hydroperoxides and downstream reactive oxygen species that lead to oxidative str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1959e5a1c2d1471ac008d744753eb1
https://pubmed.ncbi.nlm.nih.gov/29542192
https://pubmed.ncbi.nlm.nih.gov/29542192