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Akademický článek

Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins

Autor: Umer Bin Abdul Aziz, Ali Saoud, Marcel Bermudez, Maren Mieth, Amira Atef, Thomas Rudolf, Christoph Arkona, Timo Trenkner, Christoph Böttcher, Kai Ludwig, Angelique Hoelzemer, Andreas C. Hocke, Gerhard Wolber, Jörg Rademann

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pneumoniae, the main cause for bacterial pneumonia. Liberation of PLY during infection leads to compromised immune system and cytolytic cell death. Here, we repo

Externí odkaz: https://doaj.org/article/d115b78ddffa4616af6f6aa528f3f42c

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Akademický článek

Author Correction: Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/a9c589d94a30489c8d0d88a9d47ad5a8

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Akademický článek

Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress, autophagy, and modulation of Src.

Autor: Mian M K Shahzad, Mildred Felder, Kai Ludwig, Hannah R Van Galder, Matthew L Anderson, Jong Kim, Mark E Cook, Arvinder K Kapur, Manish S Patankar

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0189524 (2018)

The goal of this study was to investigate the anti-cancer effects of Trans10,cis12 conjugated linoleic acid (t10,c12 CLA). MTT assays and QCM™ chemotaxis 96-wells were used to test the effect of t10,c12 CLA on the proliferation and migration and in

Externí odkaz: https://doaj.org/article/1393d9ac57394cd1afb5e6e5335b6917

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Akademický článek

Potential of acylated peptides to target the influenza A virus

Autor: Daniel Lauster, Damian Pawolski, Julian Storm, Kai Ludwig, Rudolf Volkmer, Henry Memczak, Andreas Herrmann, Sumati Bhatia

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 589-595 (2015)

For antiviral drug design, especially in the field of influenza virus research, potent multivalent inhibitors raise high expectations for combating epidemics and pandemics. Among a large variety of covalent and non-covalent scaffold systems for a mul

Externí odkaz: https://doaj.org/article/033c3cc0daee416f990d1cc606d5cb7d

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Akademický článek

Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53.

Autor: Yang Liu, Rebecca J Whelan, Bikash R Pattnaik, Kai Ludwig, Enkateswar Subudhi, Helen Rowland, Nick Claussen, Noah Zucker, Shitanshu Uppal, David M Kushner, Mildred Felder, Manish S Patankar, Arvinder Kapur

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e53178 (2012)

Novel strategies are necessary to improve chemotherapy response in advanced and recurrent endometrial cancer. Here, we demonstrate that terpenoids present in the Steam Distilled Extract of Ginger (SDGE) are potent inhibitors of proliferation of endom

Externí odkaz: https://doaj.org/article/af28e86b6aa54ab8b87e3ae4a9a1f045

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Dendritic polyglycerolsulfate-SS-poly(ester amide) micelles for the systemic delivery of docetaxel: pushing the limits of stability through the insertion of π–π interactions

Autor: Daniel Braatz, Justus H. Peter, Mathias Dimde, Elisa Quaas, Kai Ludwig, Katharina Achazi, Michael Schirner, Matthias Ballauff, Rainer Haag

Publikováno v: Journal of Materials Chemistry B. 11:3797-3807

Insufficient stability of micellar drug delivery systems is still the major limitation to their systematic application in chemotherapy. This work demonstrates novel π-electron stabilized polyelectrolyte block copolymer micelles based on dendritic po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35fd4d0b1aef0cf27663575c6a1e391
https://doi.org/10.1039/d3tb00055a

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Market Entry Strategies for Reaching the Critical User Mass of a Digital Platform for Third Mission and Transfer at Universities

Autor: Anja Klinner, Kai Ludwig, Sebastian Moritz

Publikováno v: Open Conference Proceedings. 2:93-98

Universities make an important contribution to regional development through transfer and third-mission activities. However, the mediation and communication of such activities often poses challenges for stakeholders. To mitigate this, the project Matc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf7e1be5f207e246c74949795f82c568
https://doi.org/10.52825/ocp.v2i.160

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