Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kai Lamottke"'
Autor:
Gareth Morris, Mona Heiland, Kai Lamottke, Haifeng Guan, Thomas D. M. Hill, Yijun Zhou, Qianjin Zhu, Stephanie Schorge, David C. Henshall
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
Drug-resistant epilepsy remains a significant clinical and societal burden, with one third of people with epilepsy continuing to experience seizures despite the availability of around 30 anti-seizure drugs (ASDs). Further, ASDs often have substantial
Externí odkaz:
https://doaj.org/article/74c315fdc0bd41c0a1cd0f3ffe2dfd61
Autor:
Csaba Laszlo, Kacper Kaminski, Haifeng Guan, Maria Fatarova, Jianbing Wei, Alexandre Bergounioux, Walter K. Schlage, Sandra Schorderet-Weber, Philippe A. Guy, Nikolai V. Ivanov, Kai Lamottke, Julia Hoeng
Publikováno v:
Molecules, Vol 27, Iss 22, p 8105 (2022)
There is an increasingly urgent call to shift industrial processes from fossil fuel feedstock to sustainable bio-based resources. This change becomes of high importance considering new budget requirements for a carbon-neutral economy. Such a transfor
Externí odkaz:
https://doaj.org/article/d5c3920366bc4a7ca545a885bc3b5d30
Autor:
Simon Galyan, Collin Ewald, Xavier Jalencas, Shyam Masrani, Selin Meral, Kai Lamottke, Jordi Mestres
Currently, there are no therapies available to modify the disease progression of Huntington’s disease (HD). Recent clinical trial failures of antisense oligonucleotide candidates in HD have demonstrated the need for new therapeutic approaches. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce027ea19ca2bec4a23ce98219bfd6bb
https://doi.org/10.21203/rs.3.rs-1562535/v1
https://doi.org/10.21203/rs.3.rs-1562535/v1
Autor:
Sébastien Daix, Dean W. Hum, Stéphane Helleboid, Kai Lamottke, Christian Dr. Haug, Géraldine Rigou, Robert Walczak, Jianbing Wei, Yijun Zhou, Linda Cambula
Publikováno v:
SLAS Discovery. 19:399-406
Plants represent a tremendous structural diversity of natural compounds that bind to many different human disease targets and are potentially useful as starting points for medicinal chemistry programs. This resource is, however, still underexploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851ef537ffe43c763132c2b4710106a0
https://doi.org/10.1177/1087057113497095
https://doi.org/10.1177/1087057113497095
Autor:
David C. Henshall, Jochen H. M. Prehn, David Goldstein, Kai Lamottke, Stephanie Schorge, Hajo M. Hamer, Felix Rosenow, Jørgen Kjems, R. Jeroen Pasterkamp
Publikováno v:
Lancet Neurology, 15(13), 1368. Lancet Publishing Group
Summary Background Temporal lobe epilepsy is a common and frequently intractable seizure disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of genes controlling neurotransmitter signalling, ion channels, synapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83f1a1a507b8e6a89b39b0fcb348042
https://pubmed.ncbi.nlm.nih.gov/27839653
https://pubmed.ncbi.nlm.nih.gov/27839653
Autor:
Wolfgang Steglich, Gerhard Bringmann, Peter Spiteller, Michael Müller, Stefan Busemann, Kai Lamottke, Matthias Reichert
Publikováno v:
European Journal of Organic Chemistry. 2004:4850-4855
The absolute stereostructures of phlegmacins A1 (3a) and B1 (3b) were determined by biosynthetic studies, quantum chemical CD calculations, and NOE experiments. In Cortinarius odorifer these compounds are formed by regioselective oxidative dimerizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6a31cf8cc02515e1db3eeb519667f99
https://doi.org/10.1002/ejoc.200400518
https://doi.org/10.1002/ejoc.200400518
Autor:
Rosa L. Dorta, and Martin Schmidt, K. Peter C. Vollhardt, Kai Lamottke, Douglas B. Grotjahn, Michael J. Eichberg
Publikováno v:
Journal of the American Chemical Society. 123:9324-9337
Five synthetic approaches to racemic strychnine (1), with the cobalt-mediated [2 + 2 + 2] cycloaddition of alkynes to indoles as the key step, are described. These include the generation and attempted cyclization of macrocycle 8 and the synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee18a236894fe16b037aaa25852a01c2
https://doi.org/10.1021/ja016333t
https://doi.org/10.1021/ja016333t
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2483-2489
The total synthesis of the pre-anthraquinones atrochrysone 1 and torosachrysone 2 in both enantiomeric forms is described. The synthesis relies on the regioselective Tebbe methylenation of a chiral diester followed by an intramolecular enol ether acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ad33a784769643929f12cd6dad6792
https://doi.org/10.1039/b003053h
https://doi.org/10.1039/b003053h
Autor:
Martin Schmidt, Rosa L. Dorta, K. Peter C. Vollhardt, Michael J. Eichberg, Douglas B. Grotjahn, Kai Lamottke
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72b5e1e946be15df9b33f2245f1b5a72
https://doi.org/10.1002/chin.200205206
https://doi.org/10.1002/chin.200205206
Publikováno v:
Organic Letters. 2:2479-2481
A short, highly convergent total synthesis of racemic isostrychnine, and thus strychnine, has been completed. The route involves 14 steps in the longest linear sequence and is highlighted by a cobalt-mediated [2 + 2 + 2]cycloaddition of an alkynylind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f96401f7823152749ea63b11de052d
https://doi.org/10.1021/ol006131m
https://doi.org/10.1021/ol006131m