Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kai Connie Wu"'
Autor:
Khampaseuth Thapa, Kai Connie Wu, Aishwarya Sarma, Eric M. Grund, Angela Szeto, Armando J. Mendez, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan
Publikováno v:
Cell & Bioscience, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Background Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calcium handling is a key
Externí odkaz:
https://doaj.org/article/56b449c48fb14bcc80a8f66ce09979f5
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93013 (2014)
Oxidative stress and glutathione (GSH) depletion are implicated in mycocystin hepatotoxicity. To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in microcystin-induced liver injury, Nrf2-null, wild-type, and Keap1-hepatocyt
Externí odkaz:
https://doaj.org/article/158520d0cc6947608bd95bb0da39843c
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59122 (2013)
Acute fasting causes elevated oxidative stress. The current study investigated the effects of the nuclear factor erythoid 2-related factor 2 (Nrf2), the sensor of oxidative stress in cells, on energy homeostasis and liver pathophysiology during fasti
Externí odkaz:
https://doaj.org/article/df064c697b5b441684d66199e37e3160
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39006 (2012)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol. Th
Externí odkaz:
https://doaj.org/article/949280a426994a9ab1d614b68a3715d0
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e44686 (2012)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes involved in antioxidant defense through binding to Antioxidant Response Elements (ARE) located in the promoter regions of thes
Externí odkaz:
https://doaj.org/article/861bf9ee9cdf4ed4be4b8961a4a08638
Publikováno v:
Toxicological Sciences. 170:260-272
Use of genetically engineered rodents is often considered a valuable exercise to assess potential safety concerns associated with the inhibition of a target pathway. When there are potential immunomodulatory risks associated with the target, these ge
Publikováno v:
Free Radical Biology and Medicine. 134:335-342
Mammals have developed a variety of antioxidant systems to protect them from the oxygen environment and toxic stimuli. Little is known about the mRNA abundance of antioxidant components during postnatal development of the liver. Therefore, the purpos
Publikováno v:
Free Radic Res
Slc7a11 (xCT) and Slc3a1 (rBAT) are cystine uptake transporters that maintain intracellular concentrations of cysteine, the rate-limiting amino acid in glutathione synthesis. This study was conducted to first determine the tissue distribution of the
Publikováno v:
Toxicology and applied pharmacology. 418
Tumor progression locus 2 (Tpl2, gene name MAP3K8), a mitogen-activated protein kinase, is widely expressed in immune and non-immune cells to integrate tumor necrosis factor (TNF), toll-like receptors (TLRs), and interleukin-1 (IL1) receptor signalin
Autor:
Angela Szeto, Stephane Gesta, Aishwarya Sarma, Rangaprasad Sarangarajan, Eric M. Grund, Armando J. Mendez, Khampaseuth Thapa, Kai Connie Wu, Niven R. Narain, Vivek K. Vishnudas
Publikováno v:
Cell & Bioscience
Cell & Bioscience, Vol 8, Iss 1, Pp 1-13 (2018)
Cell & Bioscience, Vol 8, Iss 1, Pp 1-13 (2018)
Background Diabetes mellitus is associated with an increased risk in diabetic cardiomyopathy (DCM) that is distinctly not attributed to co-morbidities with other vasculature diseases. To date, while dysregulation of calcium handling is a key hallmark