Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Kai C Wollert"'
Autor:
Susanna Lemmelä, Eleanor M Wigmore, Christian Benner, Aki S Havulinna, Rachel MY Ong, Tibor Kempf, Kai C Wollert, Stefan Blankenberg, Tanja Zeller, James E Peters, Veikko Salomaa, Maria Fritsch, Ruth March, Aarno Palotie, Mark Daly, Adam S Butterworth, Mervi Kinnunen, Dirk S Paul, Athena Matakidou
Publikováno v:
eLife, Vol 11 (2022)
Growth differentiation factor-15 (GDF15) is a stress response cytokine that is elevated in several cardiometabolic diseases and has attracted interest as a potential therapeutic target. To further explore the association of GDF15 with human disease,
Externí odkaz:
https://doaj.org/article/947c9e05c4c4431bb9e58e17bc7039ee
Autor:
Andrea Grund, Malgorzata Szaroszyk, Mortimer Korf‐Klingebiel, Mona Malek Mohammadi, Felix A Trogisch, Ulrike Schrameck, Anna Gigina, Christopher Tiedje, Matthias Gaestel, Theresia Kraft, Jan Hegermann, Sandor Batkai, Thomas Thum, Andreas Perrot, Cris dos Remedios, Eva Riechert, Mirko Völkers, Shirin Doroudgar, Andreas Jungmann, Ralf Bauer, Xiaoke Yin, Manuel Mayr, Kai C Wollert, Andreas Pich, Hua Xiao, Hugo A Katus, Johann Bauersachs, Oliver J Müller, Joerg Heineke
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-20 (2019)
Abstract Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically, the identification of negative regulators of cardiomyocyte protein synthesis is n
Externí odkaz:
https://doaj.org/article/f9470b276260446599ccfd463aeb960b
Autor:
Mona Malek Mohammadi, Badder Kattih, Andrea Grund, Natali Froese, Mortimer Korf‐Klingebiel, Anna Gigina, Ulrike Schrameck, Carsten Rudat, Qiangrong Liang, Andreas Kispert, Kai C Wollert, Johann Bauersachs, Joerg Heineke
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 2, Pp 265-279 (2017)
Abstract Heart failure is often the consequence of insufficient cardiac regeneration. Neonatal mice retain a certain capability of myocardial regeneration until postnatal day (P)7, although the underlying transcriptional mechanisms remain largely unk
Externí odkaz:
https://doaj.org/article/df2851935f7949dea1f62a64768c2d67
Autor:
Mona Malek Mohammadi, Badder Kattih, Andrea Grund, Natali Froese, Mortimer Korf‐Klingebiel, Anna Gigina, Ulrike Schrameck, Carsten Rudat, Qiangrong Liang, Andreas Kispert, Kai C Wollert, Johann Bauersachs, Joerg Heineke
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 6, Pp n/a-n/a (2019)
Externí odkaz:
https://doaj.org/article/ba9511e0c2b645b48c20814daa8ebb5b
Autor:
Astrid Breitbart, Gesine M Scharf, David Duncker, Christian Widera, Jens Gottlieb, Arndt Vogel, Sebastian Schmidt, Gudrun Brandes, Hans-Gert Heuft, Ralf Lichtinghagen, Tibor Kempf, Kai C Wollert, Johann Bauersachs, Joerg Heineke
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80454 (2013)
BACKGROUND: Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary di
Externí odkaz:
https://doaj.org/article/912d68064ba24d4889b7961b4b6afdd7
Autor:
Lars Wallentin, Björn Zethelius, Lars Berglund, Kai M Eggers, Lars Lind, Bertil Lindahl, Kai C Wollert, Agneta Siegbahn
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e78797 (2013)
The objective was to evaluate the hypothesis that growth-differentiation factor 15 (GDF-15) is an independent marker of the long-term risk for both cardiovascular disease and cancer morbidity beyond clinical and biochemical risk factors. Plasma obtai
Externí odkaz:
https://doaj.org/article/f3b0f2f404d44cb39d0b27003553a31b
Autor:
Ingo Hilgendorf, Johannes Backs, Stephan Baldus, Jessy Chen, David Duncker, Ali El-Armouche, Norbert Frey, Denise Hilfiker-Kleiner, Victoria Johnson, Stephan Künzel, Kai C. Wollert, Andreas Zeiher, Hendrik B. Sager
Publikováno v:
Die Kardiologie. 17:6-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::880c5e92c3a9c407f954bf597018b643
https://doi.org/10.1007/s12181-022-00582-0
https://doi.org/10.1007/s12181-022-00582-0
Autor:
Eri Toda Kato, David A Morrow, Jianping Guo, David D Berg, Michael A Blazing, Erin A Bohula, Marc P Bonaca, Christopher P Cannon, James A de Lemos, Robert P Giugliano, Petr Jarolim, Tibor Kempf, L Kristin Newby, Michelle L O’Donoghue, Marc A Pfeffer, Nader Rifai, Stephen D Wiviott, Kai C Wollert, Eugene Braunwald, Marc S Sabatine
Publikováno v:
European Heart Journal. 44:293-300
Aims Levels of growth differentiation factor 15 (GDF-15), a cytokine secreted in response to cellular stress and inflammation, have been associated with multiple types of cardiovascular (CV) events. However, its comparative prognostic performance acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4761456818b90545aacae1296b39cca8
https://doi.org/10.1093/eurheartj/ehac577
https://doi.org/10.1093/eurheartj/ehac577
Autor:
Olga S. Kustikova, Kai C. Wollert, Natalie Weber, Johann Bauersachs, Theresia Kraft, Joop van den Heuvel, Marinos Kallikourdis, Yong Wang, Axel Schambach, Felix Polten, Gianluigi Condorelli, Evangelos Giannitsis, Julian D. Widder, Xuekun Wu, Marc R. Reboll, Paolo Kunderfranco, Felix Jäckle, Mortimer Korf-Klingebiel, Andreas Pich
Publikováno v:
Circulation. 144:1227-1240
Background: Inflammation contributes to the pathogenesis of heart failure, but there is limited understanding of inflammation’s potential benefits. Inflammatory cells secrete MYDGF (myeloid-derived growth factor) to promote tissue repair after acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9df54117348699497cb2253d20d4886
https://doi.org/10.1161/circulationaha.120.053365
https://doi.org/10.1161/circulationaha.120.053365
Autor:
Sean P. Reuter, Mark H. Soonpaa, Dorothy Field, Ed Simpson, Michael Rubart-von der Lohe, Han Kyu Lee, Arthi Sridhar, Stephanie M. Ware, Nick Green, Xiaochun Li, Susan Ofner, Douglas A. Marchuk, Kai C. Wollert, Loren J. Field
Publikováno v:
Circulation.
Background: Identifying genetic variants that affect the level of cell cycle reentry and establishing the degree of cell cycle progression in those variants could help guide development of therapeutic interventions aimed at effecting cardiac regenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59cc26eb94bae91ceb524845fdcc3af
https://pubmed.ncbi.nlm.nih.gov/36382596
https://pubmed.ncbi.nlm.nih.gov/36382596