Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kai Blumbach"'
Autor:
Agustin Casadesus, Tanja Razinger, Vasanthi Mowat, Owen P. Green, Kai Blumbach, Elke Hartmann, Stephen Corney, Ailsa Jackson, Klaus Weber, Hans-Jörg Chevalier, Stefan Kaiser
Publikováno v:
Journal of Toxicologic Pathology
Many variables may affect the outcome of continuous infusion studies. The results largely depend on the experience of the laboratory performing these studies, the technical equipment used, the choice of blood vessels and hence the surgical technique
Publikováno v:
Toxicological Sciences. 103:371-381
The kidney is one of the main targets of xenobiotic-induced toxicity, but early detection of renal damage is difficult. Recently, several novel biomarkers of nephrotoxicity have been identified by transcription profiling, including kidney injury mole
Publikováno v:
Toxicological Sciences. 53:24-32
Dimethyl methylphosphonate (DMMP) is a widely used chemical. Diethyl ethylphosphonate (DEEP) has been proposed as a replacement for DMMP in several applications. A long-term carcinogenesis study with DMMP in rats and mice showed a significant increas
Autor:
Kai Blumbach, Takayuki Anzai, Seungwoo Song, Emily A. Frische, Tanja Razinger, Peter C. Mann, Jerry F. Hardisty, Klaus Weber, Kellie C. Martel, Stephen Hillen, Hans-Jörg Chevalier
Publikováno v:
International journal of toxicology. 30(2)
The discussion on whether the Sprague Dawley (SD), the Fischer F344, or the Hannover Wistar rat is the most appropriate model for toxicity studies in rodents is ongoing. A substantial quantity of data on these strains concerning their source, diet, a
Autor:
Werner K. Lutz, Regina Draheim, Angela Mally, Wolfgang Dekant, Ulrich Steger, Sibel Ozden, Kai Blumbach, Klaus Weber, Gordon C. Hard, Eva Rached
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 97(2)
Ochratoxin A (OTA) is nephrotoxic and a potent renal carcinogen. Male rats are most susceptible to OTA toxicity, and chronic administration of OTA (70 and 210 microg/kg bw) for 2 years has been shown to induce high incidences of adenomas and carcinom
Publikováno v:
Analytical biochemistry. 267(1)
The renal accumulation of alpha2u-globulin has been implicated in the tumorigenicity of many nongenotoxic chemicals to the kidney of the male rat. Several chemicals inducing renal tumors in the male rat were shown to bind to alpha2u-globulin. This bi
Publikováno v:
Toxicological Sciences; Jun2008, Vol. 103 Issue 2, p371-371, 1p
Autor:
Eva Rached, Gordon C. Hard, Kai Blumbach, Klaus Weber, Regina Draheim, Werner K. Lutz, Sibel Özden, Ulrich Steger, Wolfgang Dekant, Angela Mally
Publikováno v:
Toxicological Sciences; Jun2007, Vol. 97 Issue 2, p288-288, 1p