Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kai Bittermann"'
Autor:
Kai Bittermann, Kai-Uwe Goss
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190319 (2017)
Experimentally derived apparent permeabilities, Papp, through cell monolayers such as Caco-2 and MDCK are considered to be an in-vitro gold standard for assessing the uptake efficiency of drugs. Here, we present a mechanistic model that describes 'pa
Externí odkaz:
https://doaj.org/article/a9d3b0d8afa3477b9538bf2d63e6c45b
Publikováno v:
Aquatic Toxicology. 207:110-119
The fish embryo toxicity (FET) test with the zebrafish Danio rerio is widely used to assess the acute toxicity of chemicals thereby serving as animal alternative to the acute fish toxicity test. The minimal toxicity of neutral chemicals in the FET ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec183777b16c2e07d55b2695c950d54
https://doi.org/10.1016/j.aquatox.2018.12.003
https://doi.org/10.1016/j.aquatox.2018.12.003
Autor:
Johannes A H, Schwöbel, Andrea, Ebert, Kai, Bittermann, Uwe, Huniar, Kai-Uwe, Goss, Andreas, Klamt
Publikováno v:
The journal of physical chemistry. B. 124(16)
We present a new and entirely mechanistic COSMO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3ea75c6c195b792f3abb2468410e98c
https://pubmed.ncbi.nlm.nih.gov/32216280
https://pubmed.ncbi.nlm.nih.gov/32216280
Publikováno v:
Environmental Science: Processes & Impacts. 20:845-853
Currently the bioaccumulation potential of organic chemicals is assessed in a first tier approach via their octanol-water partition coefficient. This approach has been developed for neutral chemicals and cannot work for ionizable and ionic chemicals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939f7d7eb84a9292ee407ef813852249
https://doi.org/10.1039/c8em00084k
https://doi.org/10.1039/c8em00084k
Autor:
Andreas Baumer, Maria König, Beate I. Escher, Luise Henneberger, Christin Kühnert, Nils Klüver, Kai Bittermann
Publikováno v:
Environmental Science: Processes & Impacts. 19:414-428
The Microtox assay, a bioluminescence inhibition assay with the marine bacterium Aliivibrio fischeri, is one of the most popular bioassays for assessing the cytotoxicity of organic chemicals, mixtures and environmental samples. Most environmental che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43a95ffad68df7d21d82af88ede9df7
https://doi.org/10.1039/c6em00692b
https://doi.org/10.1039/c6em00692b
Publikováno v:
Chemosphere. 144:382-391
A large fraction of commercially used chemicals is ionizable. This results in the need for mechanistic models to describe the physicochemical properties of ions, like the membrane-water partition coefficient (K(mw)), which is related to toxicity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1929bbb46bb80605dc19dffb7b382841
https://doi.org/10.1016/j.chemosphere.2015.08.065
https://doi.org/10.1016/j.chemosphere.2015.08.065
Publikováno v:
Chemosphere. 199
In this work we combine partition coefficients between water and membrane lipid, storage lipid, the plasma protein albumin as well as structural protein with the tissue dependent fraction of the respective phases in order to obtain a clearer picture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19d05be878a310b9735a2b5c139317f
https://pubmed.ncbi.nlm.nih.gov/29438944
https://pubmed.ncbi.nlm.nih.gov/29438944
Publikováno v:
Environmental science. Processesimpacts. 19(7)
In numerous studies on the toxicity of ionisable organic chemicals, it has been shown that the toxicity was typically higher, when larger fractions of the neutral species were present. This observation was explained in some cases by slower uptake of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e3bee8109d0b6b528a5a44af6bf6b9
https://pubmed.ncbi.nlm.nih.gov/28574566
https://pubmed.ncbi.nlm.nih.gov/28574566
Autor:
Kai Bittermann, Kai-Uwe Goss
Publikováno v:
Chemosphere. 183
Charged organic chemicals are a prevailing challenge for toxicity modelling. In this contribution we strive to recapitulate the lessons learned from the well-known modelling of narcosis (or baseline toxicity) of neutral chemicals and apply the concep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7dfdb35916e0a164bc32e0b7309342
https://pubmed.ncbi.nlm.nih.gov/28554025
https://pubmed.ncbi.nlm.nih.gov/28554025
Autor:
Andreas Klamt, Kai-Uwe Goss, Larissa Pohler, Simon Spycher, Kai Bittermann, Uwe Huniar, Satoshi Endo
Publikováno v:
The Journal of Physical Chemistry B. 118:14833-14842
The partition coefficient of chemicals from water to phospholipid membrane, K(lipw), is of central importance for various fields. For neutral organic molecules, log K(lipw) correlates with the log of bulk solvent-water partition coefficients such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe2b1eedaa6dff70bbd6e826b7c8576
https://doi.org/10.1021/jp509348a
https://doi.org/10.1021/jp509348a