Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kai‐Wen Hsu"'
Autor:
Pei-Hua Peng, Ji-Lin Chen, Heng-Hsiung Wu, Wen-Hao Yang, Li-Jie Lin, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Jia-Ling Syu, Han-Tsang Wu, Fei-Ting Hsu, Wei-Chung Cheng, Kai-Wen Hsu
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background The hypoxia-responsive long non-coding RNA, RP11-367G18.1, has recently been reported to induce histone 4 lysine 16 acetylation (H4K16Ac) through its variant 2; however, the underlying molecular mechanism remains poorly understood
Externí odkaz:
https://doaj.org/article/8dd4697709b048498ccf690dad5a8067
Autor:
I‐Hung Shao, Pei‐Hua Peng, Heng‐Hsiung Wu, Ji‐Lin Chen, Joseph Chieh‐Yu Lai, Jeng‐Shou Chang, Han‐Tsang Wu, Kou‐Juey Wu, See‐Tong Pang, Kai‐Wen Hsu
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9788-9801 (2023)
Abstract Purpose Metastasis is the end stage of renal cell carcinoma (RCC), and clear cell renal cell carcinoma (ccRCC) is the most common malignant subtype. The hypoxic microenvironment is a common feature in ccRCC and plays an essential role in the
Externí odkaz:
https://doaj.org/article/0a9475d585f249369bc43712fd3e745c
Autor:
Chia-Hwa Lee, Kai-Wen Hsu, Yao-Yu Hsieh, Wei-Ting Li, Yuqing Long, Chun-Yu Lin, Shu-Huey Chen
Publikováno v:
Cells, Vol 13, Iss 7, p 616 (2024)
The management of chronic myelogenous leukemia (CML) has seen significant progress with the introduction of tyrosine kinase inhibitors (TKIs), particularly Imatinib. However, a notable proportion of CML patients develop resistance to Imatinib, often
Externí odkaz:
https://doaj.org/article/165aab354845489f968f0785178844c6
Autor:
Kai-Wen Hsu, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Pei-Hua Peng, Ching-Hui Huang, Der-Yen Lee, Yu-Cheng Tsai, Chi-Jung Chung, Han Chang, Chao-Hsiang Chang, Ji-Lin Chen, See-Tong Pang, Ziyang Hao, Xiao-Long Cui, Chuan He, Kou-Juey Wu
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-37 (2022)
Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian cells and its nuclear role remains elusive. Results Here we show that hypoxia induces nuclear 6mA modification through a DNA methyltransferase, METTL4, in hypoxia-in
Externí odkaz:
https://doaj.org/article/6c0fad365ca1454eb69e277ce3013571
Autor:
Ming‐Lin Tsai, Chia‐Hwa Lee, Li‐Chi Huang, Yu‐Hsin Chen, Wei‐Ni Liu, Chun‐Yu Lin, Kai‐Wen Hsu, Ai‐Wei Lee, Ching‐Ling Lin
Publikováno v:
FEBS Open Bio, Vol 12, Iss 5, Pp 993-1005 (2022)
Squamous and anaplastic thyroid cancers are the most aggressive and life‐threatening cancer types in humans, with the involvement of lymph nodes in 59% of cases and distant metastases in 26% of cases of all thyroid cancers. The median survival of s
Externí odkaz:
https://doaj.org/article/b8171e1b966a43719b467e1126d0216c
Autor:
Chia-Hsin Liu, Shu-Hsuan Liu, Yo-Liang Lai, Yi-Chun Cho, Fang-Hsin Chen, Li-Jie Lin, Pei-Hua Peng, Chia-Yang Li, Shu-Chi Wang, Ji-Lin Chen, Heng-Hsiung Wu, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng, Kai-Wen Hsu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4626-4635 (2022)
Lung cancer is a major cause of cancer-associated deaths worldwide, and lung adenocarcinoma (LUAD) is the most common lung cancer subtype. Micro RNAs (miRNAs) regulate the pattern of gene expression in multiple cancer types and have been explored as
Externí odkaz:
https://doaj.org/article/0142da904d0e48d8bb1bb3790a3773d0
Publikováno v:
Biomedical Journal, Vol 44, Iss 5, Pp 521-533 (2021)
Long noncoding RNAs (lncRNAs) are noncoding RNAs with length greater than 200 nt. The biological roles and mechanisms mediated by lncRNAs have been extensively investigated. Hypoxia is a proven microenvironmental factor that promotes solid tumor meta
Externí odkaz:
https://doaj.org/article/86ef44f5776c45a98ea67ef8c448ff89
Autor:
Shu-Hsuan Liu, Kai-Wen Hsu, Yo-Liang Lai, Yu-Feng Lin, Fang-Hsin Chen, Pei-Hwa Peng, Li-Jie Lin, Heng-Hsiung Wu, Chia-Yang Li, Shu-Chi Wang, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 1-10 (2021)
Lung adenocarcinoma (LUAD), the most common histological type of non-small cell lung cancer, is one of the most malignant and deadly diseases. Current treatments for advanced LUAD patients are far from ideal and require further improvements. Here, we
Externí odkaz:
https://doaj.org/article/cd747dbc44cd48deb46fab9b2c4a9054
Autor:
Yumei Qi, Yo-Liang Lai, Pei-Chun Shen, Fang-Hsin Chen, Li-Jie Lin, Heng-Hsiung Wu, Pei-Hua Peng, Kai-Wen Hsu, Wei-Chung Cheng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Cervical cancer is the fourth most common cancer in women worldwide. Increasing evidence has shown that miRNAs are related to the progression of cervical cancer. However, the mechanisms that affect the prognosis of cancer are still largely u
Externí odkaz:
https://doaj.org/article/12a635dbd4f94295b89f26b127f24e09
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101302- (2022)
Breast cancer is common worldwide, and the estrogen receptor-positive subtype accounts for approximately 70% of breast cancer in women. Tamoxifen and fulvestrant are drugs currently used for endocrinal therapy. Breast cancer exhibiting endocrine resi
Externí odkaz:
https://doaj.org/article/74d34cfe1cbf4952a67eb644f947fcf1