Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kai‐Uwe Schmidtke"'
Autor:
Susanne Steinbrecht, Jan Kiebist, Rosalie König, Markus Thiessen, Kai-Uwe Schmidtke, Sarah Kammerer, Jan-Heiner Küpper, Katrin Scheibner
Publikováno v:
AMB Express, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Cyclophosphamide (CPA) represents a widely used anti-cancer prodrug that is converted by liver cytochrome P450 (CYP) enzymes into the primary metabolite 4-hydroxycyclophosphamide (4-OH-CPA), followed by non-enzymatic generation of the bioact
Externí odkaz:
https://doaj.org/article/02be8937c7c9421ca3f00981bdaa4085
Autor:
Rosalie König, Jan Kiebist, Johannes Kalmbach, Robert Herzog, Kai-Uwe Schmidtke, Harald Kellner, René Ullrich, Nico Jehmlich, Martin Hofrichter, Katrin Scheibner
Publikováno v:
Microorganisms, Vol 10, Iss 7, p 1267 (2022)
Lipid mediators, such as epoxidized or hydroxylated eicosanoids (EETs, HETEs) of arachidonic acid (AA), are important signaling molecules and play diverse roles at different physiological and pathophysiological levels. The EETs and HETEs formed by th
Externí odkaz:
https://doaj.org/article/7d38250e370f4af6b90a50dc921b327a
Cell-Free Protein Synthesis with Fungal Lysates for the Rapid Production of Unspecific Peroxygenases
Autor:
Marina Schramm, Stephanie Friedrich, Kai-Uwe Schmidtke, Jan Kiebist, Paul Panzer, Harald Kellner, René Ullrich, Martin Hofrichter, Katrin Scheibner
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 284 (2022)
Unspecific peroxygenases (UPOs, EC 1.11.2.1) are fungal biocatalysts that have attracted considerable interest for application in chemical syntheses due to their ability to selectively incorporate peroxide-oxygen into non-activated hydrocarbons. Howe
Externí odkaz:
https://doaj.org/article/9b35775b943c46fba44b2b3d84b3612a
Autor:
Jan Kiebist, Kai-Uwe Schmidtke, Marina Schramm, Rosalie König, Stephan Quint, Johannes Kohlmann, Ralf Zuhse, René Ullrich, Martin Hofrichter, Katrin Scheibner
Publikováno v:
Journal of Fungi, Vol 7, Iss 9, p 752 (2021)
Antithrombotic thienopyridines, such as clopidogrel and prasugrel, are prodrugs that undergo a metabolic two-step bioactivation for their pharmacological efficacy. In the first step, a thiolactone is formed, which is then converted by cytochrome P450
Externí odkaz:
https://doaj.org/article/8d4c1b107522450a94ee6d7faa5716bd
Autor:
Harald Kellner, Stephanie Friedrich, Kai-Uwe Schmidtke, René Ullrich, Jan Kiebist, Daniel Zänder, Martin Hofrichter, Katrin Scheibner
Publikováno v:
Microbiology resource announcements. 11(7)
The ascomycete Truncatella angustata has a worldwide distribution. Commonly, it is associated with plants as an endophyte, pathogen, or saprotroph. The genome assembly comprises 44.9 Mbp, a G+C content of 49.2%, and 12,353 predicted genes, among them
Autor:
Mengyi Wang, Sabrina Wamp, Johannes Gibhardt, Gudrun Holland, Inge Schwedt, Kai‐Uwe Schmidtke, Katrin Scheibner, Sven Halbedel, Fabian M. Commichau
Publikováno v:
Environmental microbiologyReferences. 24(9)
The human pathogen Listeria monocytogenes synthesizes and degrades c-di-AMP using the diadenylate cyclase CdaA and the phosphodiesterases PdeA and PgpH respectively. c-di-AMP is essential because it prevents the uncontrolled uptake of osmolytes. Here
Autor:
Jan Kiebist, Sarah Kammerer, Katrin Scheibner, Rosalie König, Kai-Uwe Schmidtke, S. Steinbrecht, Markus Thiessen, Jan-Heiner Küpper
Publikováno v:
AMB Express, Vol 10, Iss 1, Pp 1-13 (2020)
AMB Express
AMB Express
Cyclophosphamide (CPA) represents a widely used anti-cancer prodrug that is converted by liver cytochrome P450 (CYP) enzymes into the primary metabolite 4-hydroxycyclophosphamide (4-OH-CPA), followed by non-enzymatic generation of the bioactive metab
Autor:
Katrin Scheibner, Daniel Zänder, Jan Kiebist, René Ullrich, Kai-Uwe Schmidtke, Jörg Zimmermann, Nico Jehmlich, Martin Hofrichter, Harald Kellner
Publikováno v:
Chembiochem
ChemBioChem
ChemBioChem
Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates, including less‐activated hydrocarbons, by transferring peroxide‐borne oxygen. We investigated a cell
Publikováno v:
Journal of Cellular Biotechnology. 1:183-190
Chronic alcohol abuse is the leading cause of liver cirrhosis in western countries. Ethanol, even at lower concentrations, can cause pleiotropic effects at the cellular level such as the formation of reactive oxygen species (ROS) and DNA damage. Etha
Autor:
Katrin Scheibner, Sebastian Sperling, Kai-Uwe Schmidtke, Amelie Lupp, Georg Damm, Natalie Herzog, Jan-Heiner Küpper, Ursula Anderer, Daniel Seehofer, Max Hansen, Sebastian Miethbauer
Publikováno v:
Cell Biology International. 40:341-353
Primary human hepatocytes are in great demand during drug development and in hepatology. However, both scarcity of tissue supply and donor variability of primary cells create a need for the development of alternative hepatocyte systems. By using a le