Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Kai, Krohn"'
Autor:
Emmi Naskali, Katja Dettmer, Peter J Oefner, Pedro A B Pereira, Kai Krohn, Petri Auvinen, Annamari Ranki, Nicolas Kluger
Publikováno v:
Endocrine Connections, Vol 8, Iss 1, Pp 69-77 (2019)
Objective: Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Patients lack entero-endocrine (EE) cells and have circulating autoanti
Externí odkaz:
https://doaj.org/article/76aa1a82178c4a93b9f94949ea98c260
Autor:
Christina Hertel, Dmytro Fishman, Anna Lorenc, Annamari Ranki, Kai Krohn, Pärt Peterson, Kai Kisand, Adrian Hayday
Publikováno v:
eLife, Vol 8 (2019)
In 2016, we reported four substantial observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T cell tolerance (Meyer et al., 2016). Two of those observations have been challenged. Specifically, ‘private’ aut
Externí odkaz:
https://doaj.org/article/24fc7f424d1e48169ad3236076219093
Autor:
Dmytro Fishman, Kai Kisand, Christina Hertel, Mike Rothe, Anu Remm, Maire Pihlap, Priit Adler, Jaak Vilo, Aleksandr Peet, Antonella Meloni, Katarina Trebusak Podkrajsek, Tadej Battelino, Øyvind Bruserud, Anette S. B. Wolff, Eystein S. Husebye, Nicolas Kluger, Kai Krohn, Annamari Ranki, Hedi Peterson, Adrian Hayday, Pärt Peterson
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibo
Externí odkaz:
https://doaj.org/article/a2c87384b96b4e2e8bda6453106b0ee0
Autor:
Pedro A. B. Pereira, Nicolas Kluger, Petri Auvinen, Emmi Naskali, Peter J. Oefner, Katja Dettmer, Annamari Ranki, Kai Krohn
Publikováno v:
Endocrine Connections
Endocrine Connections, Vol 8, Iss 1, Pp 69-77 (2019)
Endocrine Connections, Vol 8, Iss 1, Pp 69-77 (2019)
Objective Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Patients lack entero-endocrine (EE) cells and have circulating autoantib
Publikováno v:
Clinical immunology (Orlando, Fla.). 219
Autor:
Anthony Meager, Kumuthini Visvalingam, Pärt Peterson, Kaidi Möll, Astrid Murumägi, Kai Krohn, Petra Eskelin, Jaakko Perheentupa, Eystein Husebye, Yoshihisa Kadota, Nick Willcox
Publikováno v:
PLoS Medicine, Vol 3, Iss 7, p e289 (2006)
The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive AIRE mutations lead to autoimmunity targetting endocrine and other epithelial tissues, al
Externí odkaz:
https://doaj.org/article/9bd180eef4174bcd8d23c4a80bc0c904
Autor:
Steffen Meyer, Annalisa Macagno, Kirsi Jäntti, Adrian Hayday, Dmytro Fishman, Martin Woodward, Pärt Peterson, Nicolas Kluger, Aleksandr Peet, Anette S. B. Wolff, Kaja Metsküla, Jaanika Kärner, Shimobi Onuoha, Antonella Meloni, Nina Bratanic, Kai Kisand, Katarina Trebušak Podkrajšek, Hedi Peterson, Kati Hokynar, Raivo Uibo, Christina Hertel, Tadej Battelino, Eystein S. Husebye, Annamari Ranki, Kai Krohn, Philip Vlaicu, Yasmin Haque
Publikováno v:
Cell
Meyer, S, Woodward, M, Hertel, C, Vlaicu, P, Haque, Y, Kärner, J, Macagno, A, Onuoha, S C, Fishman, D, Peterson, H, Metsküla, K, Uibo, R, Jäntti, K, Hokynar, K, Wolff, A S B, Meloni, A, Kluger, N, Husebye, E S, Podkrajsek, K T, Battelino, T, Bratanic, N, Peet, A, Krohn, K, Ranki, A, Peterson, P, Kisand, K & Hayday, A 2016, ' AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies ', Cell, vol. 166, no. 3, pp. 582-595 . https://doi.org/10.1016/j.cell.2016.06.024
Meyer, S, Woodward, M, Hertel, C, Vlaicu, P, Haque, Y, Kärner, J, Macagno, A, Onuoha, S C, Fishman, D, Peterson, H, Metsküla, K, Uibo, R, Jäntti, K, Hokynar, K, Wolff, A S B, Meloni, A, Kluger, N, Husebye, E S, Podkrajsek, K T, Battelino, T, Bratanic, N, Peet, A, Krohn, K, Ranki, A, Peterson, P, Kisand, K & Hayday, A 2016, ' AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies ', Cell, vol. 166, no. 3, pp. 582-595 . https://doi.org/10.1016/j.cell.2016.06.024
Summary APS1/APECED patients are defined by defects in the autoimmune regulator (AIRE) that mediates central T cell tolerance to many self-antigens. AIRE deficiency also affects B cell tolerance, but this is incompletely understood. Here we show that
Autor:
Mahmoud Habibullah, Nicolas Kluger, Edward M. Brown, Anthony P. Weetman, Maria Luisa Brandi, Julie A. Porter, E. Helen Kemp, Kai Krohn, Annamari Ranki
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(11)
A major manifestation of autoimmune polyendocrine syndrome type 1 (APS1) is hypoparathyroidism, which is suggested to result from aberrant immune responses against the parathyroid glands. The calcium-sensing receptor (CaSR), which plays a pivotal rol
Autor:
Annamari Ranki, Martina Dobešová, Jana Balounova, Ales Neuwirth, Kai Krohn, Dominik Filipp, Matouš Vobořil, Ondřej Ballek, Jan Lebl, Antonella Meloni, Nicolas Kluger, Jan Dobeš
Publikováno v:
Gastroenterology. 149:139-150
Background & Aims Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autoimmune disorder characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency, but patients also develop intestina