Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kai, Dittmann"'
Autor:
Natalie Geyer, Rosalie Ridzewski, Julia Bauer, Maria Kuzyakova, Kai Dittmann, Christian Dullin, Albert Rosenberger, Hans-Ulrich Schildhaus, Anja Uhmann, Simone Fulda, Heidi Hahn
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylino
Externí odkaz:
https://doaj.org/article/0b4b41a0b14241158a193fc533725a79
Autor:
Simone König, Frauke Nitzki, Anja Uhmann, Kai Dittmann, Jennifer Theiss-Suennemann, Markus Herrmann, Holger M Reichardt, Reto Schwendener, Tobias Pukrop, Walter Schulz-Schaeffer, Heidi Hahn
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93555 (2014)
Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse m
Externí odkaz:
https://doaj.org/article/e330aa80843a4dd0bbf5f0d15e43be40
Autor:
Diana Marklein, Ulrike Graab, Ivonne Naumann, Tiandong Yan, Rosalie Ridzewski, Frauke Nitzki, Albert Rosenberger, Kai Dittmann, Jürgen Wienands, Leszek Wojnowski, Simone Fulda, Heidi Hahn
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52898 (2012)
We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis.
Externí odkaz:
https://doaj.org/article/020fc499aaa144d3854f585b67f7895b
Autor:
Natalie, Geyer, Rosalie, Ridzewski, Julia, Bauer, Maria, Kuzyakova, Kai, Dittmann, Christian, Dullin, Albert, Rosenberger, Hans-Ulrich, Schildhaus, Anja, Uhmann, Simone, Fulda, Heidi, Hahn
Publikováno v:
Frontiers in Oncology
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8ce340dc59607f6388c94b0950c9976
https://pubmed.ncbi.nlm.nih.gov/30319965
https://pubmed.ncbi.nlm.nih.gov/30319965
Publikováno v:
J. Biol. Chem. 290, 19614-19628 (2015)
The Patched1 (Ptch)-mediated inhibition of Smoothened (Smo) is still an open question. However, a direct Ptch/Smo interaction has been excluded, Smo modulators were identified, but the endogenous signal transmitting molecule remains undiscovered. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4490b610d91463cb6828b67a98c3cb
https://doi.org/10.1074/jbc.m115.646141
https://doi.org/10.1074/jbc.m115.646141
Autor:
Kai Dittmann, Anja Uhmann, Christian Dullin, Stefan Schweyer, Jürgen Wienands, Andrea Vortkamp, Manuela Wuelling, Heidi Hahn
Publikováno v:
Arthritis & Rheumatology. 66:831-840
Objective During development of the vertebrate skeleton, chondrocytes form a cartilage template that is gradually replaced by bone. Hormones of the Hedgehog (HH) family have been implicated in the ossification process, but their exact relationship to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30419a224a0b1bcf1e08b94434304f9
https://doi.org/10.1002/art.38325
https://doi.org/10.1002/art.38325
Autor:
Henning Urlaub, Kai Dittmann, He-Hsuan Hsiao, Hubert Serve, Jürgen Wienands, Michael Engelke, Christian Griesinger, Thomas Oellerich
Publikováno v:
Journal of Immunology
Ag-mediated B cell stimulation relies on phospholipase Cγ2 (PLCγ2) for Ca2+ mobilization. Enzymatic activity of PLCγ2 is triggered upon Src homology 2 domain–mediated binding to the tyrosine-phosphorylated adaptor SLP65. However, SLP65 phosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1ec838dbe0275ac3d146c1a237b5c7
https://doi.org/10.4049/jimmunol.1301326
https://doi.org/10.4049/jimmunol.1301326
Autor:
Tommy Regen, Simone König, Tobias Pukrop, Heidi Hahn, Kai Dittmann, Michael Engelke, Jürgen Wienands, Reto A. Schwendener, Uwe-Karsten Hanisch
Publikováno v:
Cancer Immunology, Immunotherapy. 62:1587-1597
Liposomes are frequently used in cancer therapy to encapsulate and apply anticancer drugs. Here, we show that a systemic treatment of mice bearing skin tumors with empty phosphatidylcholine liposomes (PCL) resulted in inhibition of tumor growth, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fef894c52086e3c587fa12e3f524adb
https://doi.org/10.1007/s00262-013-1444-4
https://doi.org/10.1007/s00262-013-1444-4
Autor:
Julia, Dräger, Katja, Simon-Keller, Tobias, Pukrop, Florian, Klemm, Jörg, Wilting, Carsten, Sticht, Kai, Dittmann, Matthias, Schulz, Ivo, Leuschner, Alexander, Marx, Heidi, Hahn
Publikováno v:
Oncotarget
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and show characteristics of skeletal muscle differentiation. The two major RMS subtypes in children are alveolar (ARMS) and embryonal RMS (ERMS). We demonstrate that approximat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23fd73bd7468db655d4bd36f8ba31860
https://pubmed.ncbi.nlm.nih.gov/27965462
https://pubmed.ncbi.nlm.nih.gov/27965462
Autor:
Henning Urlaub, Hanibal Bohnenberger, Michael Engelke, Facundo D. Batista, Tim Schnyder, Jürgen Wienands, Kai Dittmann, Konstantin Neumann, He-Hsuan Hsiao, Vanessa Bremes, Thomas Oellerich
Publikováno v:
The EMBO Journal. 30:3620-3634
Spleen tyrosine kinase Syk and its substrate SLP65 (also called BLNK) are proximal signal transducer elements of the B-cell antigen receptor (BCR). Yet, our understanding of signal initiation and processing is limited owing to the incomplete list of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c8ab8862d794dfb71cdda22f31940f0
https://doi.org/10.1038/emboj.2011.251
https://doi.org/10.1038/emboj.2011.251