Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kahori Shimizu"'
Autor:
Shotaro Michinaga, Kiyomi Sonoda, Naoki Inazuki, Manae Ezaki, Hiroki Awane, Kahori Shimizu, Shigeru Hishinuma, Hiroyuki Mizuguchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 3, Pp 135-145 (2022)
Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H2 receptors. Herein, we investigated the effects of H2 receptor agonists on the blood-brain barrier (BBB) disruption after traumatic brain injury (TBI). M
Externí odkaz:
https://doaj.org/article/fad084cfabaa422888c1d783a421ac56
Autor:
Kahori Shimizu, Syogo Nishimuta, Yuri Fukumura, Shotaro Michinaga, Yuka Egusa, Tomomi Hase, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita, Toru Nishinaka
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274297 (2022)
The liver is the main organ that regulates lipid and glucose metabolism. Ectopic lipid accumulation in the liver impairs insulin sensitivity and glucose metabolism. Lipoprotein lipase (LPL), mainly expressed in the adipose tissue and muscle, is a key
Externí odkaz:
https://doaj.org/article/43b57908284e46f9960d1a8ccb6ca095
Autor:
Kahori Shimizu, Minako Okamoto, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita, Toru Nishinaka
Publikováno v:
Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 192-197 (2017)
Japanese patients with type 2 diabetes mellitus present a different responsiveness in terms of insulin secretion to glucose and body mass index (BMI) from other populations. The genetic background that predisposes Japanese individuals to type 2 diabe
Externí odkaz:
https://doaj.org/article/ab4e7c3304de4a79af9472b7db76a604
Autor:
Hiroyuki Mizuguchi, Kenji Kawabata, Fuminori Sakurai, Kazufumi Katayama, Mitsuhiro Machitani, Kahori Shimizu, Tomoko Yamaguchi
Publikováno v:
Pharmaceutics, Vol 3, Iss 3, Pp 338-353 (2011)
The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vecto
Externí odkaz:
https://doaj.org/article/02b38c0320d0490ba67dec43290044ec
Autor:
Kahori Shimizu, Fuminori Sakurai, Kyoko Tomita, Yasuhito Nagamoto, Shin-ichiro Nakamura, Kazufumi Katayama, Masashi Tachibana, Kenji Kawabata, Hiroyuki Mizuguchi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Leaky expression of adenovirus (Ad) genes occurs following transduction with a conventional replication-incompetent Ad vector, leading to an induction of cellular immunity against Ad proteins and Ad protein-induced toxicity, especially in the late ph
Externí odkaz:
https://doaj.org/article/0c86e51c8c5d404085002a2e2863ce7e
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1759-1766
Vasogenic edema results from blood-brain barrier (BBB) disruption after traumatic brain injury (TBI), and although it can be fatal, no promising therapeutic drugs have been developed as yet. Transient receptor potential vanilloid 4 (TRPV4) is a calci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d581100f3783472ddaaeef73f0892b3
https://doi.org/10.1248/bpb.b21-00512
https://doi.org/10.1248/bpb.b21-00512
Autor:
Kazuaki Chayama, Fumitaka Nishimae, Ryosuke Ono, Eiko Sakai, Kahori Shimizu, Yuji Ishida, Fuminori Sakurai, Hiroyuki Mizuguchi, Chise Tateno, Tomohito Tsukamoto, Aoi Shiota, Shunsuke Iizuka
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1506-1513
Replication-incompetent adenovirus (Ad) vectors are promising gene delivery vehicles, especially for hepatocytes, due to their superior hepatic tropism; however, in vivo application of an Ad vector often results in hepatotoxicity, mainly due to the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee5435a6659671918f64033a2994b9a
https://doi.org/10.1248/bpb.b21-00394
https://doi.org/10.1248/bpb.b21-00394
Autor:
Fumitaka Nishimae, Shinichiro Nakamura, Ryosuke Ono, Shunsuke Iizuka, Hiroyuki Mizuguchi, Tomohito Tsukamoto, Kahori Shimizu, Toru Nishinaka, Yasushi Fujio, Fuminori Sakurai, Tomoyuki Terada
Publikováno v:
The Journal of Immunology. 206:410-421
Adenovirus (Ad) vector–mediated transduction can cause hepatotoxicity during two phases, at ∼2 and 10 days after administration. Early hepatotoxicity is considered to involve inflammatory cytokines; however, the precise mechanism remains to be cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c59710302f9bddc36e4edfd5786781
https://doi.org/10.4049/jimmunol.2000830
https://doi.org/10.4049/jimmunol.2000830
Autor:
Shotaro, Michinaga, Kiyomi, Sonoda, Naoki, Inazuki, Manae, Ezaki, Hiroki, Awane, Kahori, Shimizu, Shigeru, Hishinuma, Hiroyuki, Mizuguchi
Publikováno v:
Journal of pharmacological sciences. 150(3)
Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8caf263a59bec9865ff1b6c9ad762aa
https://pubmed.ncbi.nlm.nih.gov/36184118
https://pubmed.ncbi.nlm.nih.gov/36184118
Publikováno v:
YAKUGAKU ZASSHI. 139:47-51
Although many treatments for type 2 diabetes mellitus (T2DM) have been developed, the quality of life for people with T2DM still tends to be lower than in those without the disease. Thus, the development of new T2DM treatments and prevention methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac292c4801405ebaeb243db9b67efe97
https://doi.org/10.1248/yakushi.18-00163-2
https://doi.org/10.1248/yakushi.18-00163-2