Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kahori Shiba"'
Autor:
Toshiki Tezuka, Mayu Ishiguro, Daisuke Taniguchi, Ehoto Osogaguchi, Kahori Shiba-Fukushima, Jun Ogata, Ryota Ishii, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Taro Matsui, Kenichi Kaida, Manabu Funayama, Kenya Nishioka, Fumihisa Kumazawa, Tomoyasu Matsubara, Hitoshi Tsuda, Yuko Saito, Shigeo Murayama, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106571- (2024)
Leucine-rich repeat kinase 2 (LRRK2) is the most common gene responsible for familial Parkinson's disease (PD). The gene product of LRRK2 contains multiple protein domains, including armadillo repeat, ankyrin repeat, leucine-rich repeat (LRR), Ras-of
Externí odkaz:
https://doaj.org/article/de656de5f6c04063a9a2a899476b1c7d
Autor:
Toshiki Tezuka, Daisuke Taniguchi, Mariko Sano, Tomoyo Shimada, Yutaka Oji, Taiji Tsunemi, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Jun Ogata, Kahori Shiba-Fukushima, Manabu Funayama, Kenya Nishioka, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-7 (2022)
Abstract Missense variants in leucine-rich repeat kinase 2 (LRRK2) lead to familial and sporadic Parkinson’s disease (PD). The pathological features of PD patients with LRRK2 variants differ. Here, we report an autopsy case harboring the LRRK2 G238
Externí odkaz:
https://doaj.org/article/f5424e9f60a54fa681ba5d764347fb97
Autor:
Tsuyoshi Inoshita, Jun-Yi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba-Fukushima, Nobutaka Hattori, Yuzuru Imai
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105476- (2022)
Summary: Some Parkinson’s disease (PD)-causative/risk genes, including the PD-associated kinase leucine-rich repeat kinase 2 (LRRK2), are involved in membrane dynamics. Although LRRK2 and other PD-associated genes are believed to regulate synaptic
Externí odkaz:
https://doaj.org/article/2f20268e8c1246de8b9fcb7023d5cab0
Autor:
Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Osamu Sano, Hidehisa Iwata, Kei-ichi Ishikawa, Hideyuki Okano, Wado Akamatsu, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Early-onset Parkinson's disease-associated PINK1-Parkin signaling maintains mitochondrial health. Therapeutic approaches for enhancing PINK1-Parkin signaling present a potential strategy for treating various diseases caused by mitochondrial
Externí odkaz:
https://doaj.org/article/71dca2e2970b4054b12d8d0ff385f488
Autor:
Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 218-227 (2017)
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra. However, the molecular relationship between p150Glue
Externí odkaz:
https://doaj.org/article/85235ce739fc410eb83359e049f8ca99
Autor:
Hongrui Meng, Chikara Yamashita, Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Tomohisa Hatta, Tohru Natsume, Masataka Umitsu, Junichi Takagi, Yuzuru Imai, Nobutaka Hattori
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing c
Externí odkaz:
https://doaj.org/article/f0f13ae34fb3421384e2c167bf51757f
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 4, p 908 (2019)
Mutations of coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10 (CHCHD10) have been found to be linked to Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and/or frontotemporal lobe dementia (FTD). CHCHD2 and CHCH
Externí odkaz:
https://doaj.org/article/2bb427f2a1c3456abf2e41ba5f8a587f
Autor:
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004861 (2014)
The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondri
Externí odkaz:
https://doaj.org/article/fe100669f56a46c7950072279f3e37e0
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004391 (2014)
Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphoryl
Externí odkaz:
https://doaj.org/article/6d8e6502b33f4074af0b9c0746866e49
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