Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kahlia Wong"'
Autor:
Aline Pfefferle, Julian Contet, Kahlia Wong, Charlotte Chen, Els Verhoeyen, Chloe K Slichter, Kimberly S Schluns, Joseph Cursons, Richard Berry, Iva Nikolic, Jai Rautela, Nicholas D Huntington
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Objectives Autologous chimeric antigen receptor (CAR) T‐cell therapy of B‐cell malignancies achieves long‐term disease remission in a high fraction of patients and has triggered intense research into translating this successful approac
Externí odkaz:
https://doaj.org/article/1c4ef2b2dbce494a9cb2a8585541cc59
Autor:
Mingjing Hu, David Eviston, Peter Hsu, Eliana Mariño, Ann Chidgey, Brigitte Santner-Nanan, Kahlia Wong, James L. Richards, Yu Anne Yap, Fiona Collier, Ann Quinton, Steven Joung, Michael Peek, Ron Benzie, Laurence Macia, David Wilson, Ann-Louise Ponsonby, Mimi L. K. Tang, Martin O’Hely, Norelle L. Daly, Charles R. Mackay, Jane E. Dahlstrom, The BIS Investigator Group, Peter Vuillermin, Ralph Nanan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.
Externí odkaz:
https://doaj.org/article/c9a435d8124048e595fe54577e177533
Autor:
Michael Ly Hun, Kahlia Wong, Josephine Rahma Gunawan, Abdulaziz Alsharif, Kylie Quinn, Ann P. Chidgey
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
One of the main consequences of thymus aging is the decrease in naïve T cell output. This condition accelerates at the onset of puberty, and presents as a major clinical complication for cancer patients who require cytoablative therapy. Specifically
Externí odkaz:
https://doaj.org/article/4e5dfc4609ea42a1ac66f302803d275c
Autor:
Ailin Lepletier, Michael L. Hun, Maree V. Hammett, Kahlia Wong, Haroon Naeem, Mark Hedger, Kate Loveland, Ann P. Chidgey
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3887-3901.e4 (2019)
Summary: A key feature of immune functional impairment with age is the progressive involution of thymic tissue responsible for naive T cell production. In this study, we identify two major phases of thymic epithelial cell (TEC) loss during aging: a b
Externí odkaz:
https://doaj.org/article/78728ec7fa0b4175a39b3c1c19c61730
Autor:
Kahlia Wong, Natalie L. Lister, Marco Barsanti, Joanna M.C. Lim, Maree V. Hammett, Danika M. Khong, Christopher Siatskas, Daniel H.D. Gray, Richard L. Boyd, Ann P. Chidgey
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1198-1209 (2014)
Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial progenitors (TEPCs) in the postnatal thymus has been inferred, but their identity has remained e
Externí odkaz:
https://doaj.org/article/05b4b09945614dcbb028965a4d7752a3
Autor:
Josephine Rahma Gunawan, Ann P. Chidgey, Abdulaziz Abdulmohsin M Alsharif, Kahlia Wong, Michael L. Hun, Kylie M. Quinn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
One of the main consequences of thymus aging is the decrease in naïve T cell output. This condition accelerates at the onset of puberty, and presents as a major clinical complication for cancer patients who require cytoablative therapy. Specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2e325b24574a9910f19de99bb0216d
https://www.frontiersin.org/article/10.3389/fimmu.2020.00302/full
https://www.frontiersin.org/article/10.3389/fimmu.2020.00302/full
Autor:
Michael L. Hun, Jerome A. Werkmeister, John A. M. Ramshaw, Marco Barsanti, Kahlia Wong, Ann P. Chidgey
Publikováno v:
Biomaterials. 118:1-15
Although the thymus is a primary lymphoid organ, its function is compromised by an age-induced loss of resident epithelial cells, which results in reduced naïve T cell output. This has important implications for immune recovery in aged and elderly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9266da6a802d3ddd8dca6523c91d66e
https://doi.org/10.1016/j.biomaterials.2016.11.054
https://doi.org/10.1016/j.biomaterials.2016.11.054
Autor:
Michael L. Hun, Richard L. Boyd, Antonietta Giudice, Kahlia Wong, Joanna M.C. Lim, Natalie Lister, Maree V. Hammett, Marco Barsanti, Ann P. Chidgey, Ailin Lepletier
Publikováno v:
European Journal of Immunology. 47:291-304
Although forkhead-box n1 (Foxn1) is a critical thymic epithelial cell regulator in thymus organogenesis, its association with epithelial differentiation and homeostasis in the postnatal and aged thymic microenvironment remains conflicting. Consequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c39b103befa2f21fd50b21d510409d
https://doi.org/10.1002/eji.201646553
https://doi.org/10.1002/eji.201646553
Autor:
Steven Joung, Michael J. Peek, Ron Benzie, Charles R. Mackay, Kahlia Wong, David P. Eviston, Martin O'Hely, Eliana Mariño, Mingjing Hu, Yu Anne Yap, James L. Richards, David Wilson, Ann Louise Ponsonby, Ralph Nanan, Peter Hsu, Ann Quinton, Ann P. Chidgey, Peter Vuillermin, Mimi L.K. Tang, Jane E. Dahlstrom, Brigitte Santner-Nanan, Norelle L. Daly, Laurence Macia, Fiona Collier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and is linked to atopic disorders in offspring. Here we show reduction of fetal thymic size, alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7545eab9b9445e09166afafca845c7
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Thymus Transcriptome and Cell Biology ISBN: 9783030120399
T cell development in the thymus requires constant interactions between developing thymocytes and the surrounding resident stromal cells (TSCs). These functional, non-hematopoietic-derived cells are predominantly of epithelial origin and constitute 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b12685e7361db7e7eff29685b648f69d
https://doi.org/10.1007/978-3-030-12040-5_13
https://doi.org/10.1007/978-3-030-12040-5_13
