Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells

Autor: Li G, Chen TW, Nickel AC, Muhammad S, Steiger HJ, Tzaridis T, Hänggi D, Zeidler R, Zhang W, Kahlert UD

Publikováno v: OncoTargets and Therapy, Vol Volume 14, Pp 1707-1718 (2021)

Guanzhang Li,1,* Ting-Wei Chen,2,* Ann-Christin Nickel,2 Sajjad Muhammad,2 Hans-Jakob Steiger,2 Theophilos Tzaridis,3,4 Daniel Hänggi,2 Reinhard Zeidler,5 Wei Zhang,6– 8 Ulf Dietrich Kahlert1,2 1Department of Molecular Neuropathology, Beijing Neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::2c5b25f9506380651a715fae169a3e9f
https://www.dovepress.com/carbonic-anhydrase-xii-is-a-clinically-significant-molecular-tumor-sub-peer-reviewed-article-OTT

Increasing the therapeutic potential of novel anti-brain cancer stem cell pharmacotherapy with gold nanotechnology

Autor: Giesen, B, Nickel, AC, Hänggi, D, Janiak, C, Kahlert, UD

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCP038 /20210604/

Objective: Stem cells in glioblastoma (GBM) are considered to be a main contributor for the high levels of therapy resistance of the disease. The identification of metabolic dependencies of those GBM stem cells (GSCs), such as glutaminase 1 activity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d976fed5f1bdabd010166bfda6655274

Synergistic effect of 5-amino-levulinic acid and gold nanoparticles in photodynamic therapy of immortalised human vestibular schwannoma cells

Autor: Karadag, C, Gull, HH, Kahlert, UD, Hänggi, D, Cornelius, JF

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCP052 /20210604/

Objective: Vestibular schwannoma (VS) is a common benign brain tumor. Current management includes wait and scan, surgery or stereotactic irradiation or a combination. Photo-dynamic therapy (PDT) was shown to be effective in a number of tumors. In ord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e9213f2defe69d70e0d9faeaf463a5

An in vitro technology to score therapeutic efficacy and risk-potential of substances for targeting brain tumours

Autor: Koch, K, Hartmann, R, Tsiampali, N, Uhlmann, C, He, X, Kamp, MA, Sabel, M, Barker, R, Willbold, D, Steiger, HJ, Maciaczyk, J, Kahlert, UD

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCP188 /20200626/

Objective: The upregulation of anabolic processes to maintain high rates of cellular turnover is considered the cancers Achilles’ heel. The intervention in altered metabolic pathways of cancer cells have emerged as a promising strategy to develop n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b9425202745bfe31a57b870ff4e22c

Pharmacological WNT-inhibition acts synergistically with chemo- and radiotherapy by overcoming treatment-resistance in glioma stem cells

Autor: Suwala, AK, Koch, K, Kahlert, UD, Maciaczyk, J

Publikováno v: 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS); 20160612-20160615; Frankfurt am Main; DOCMI.02.04 /20160608/

Objective: Glioma Stem Cells (GSCs) are considered to be responsible for dismal prognosis of Glioblastoma (GBM). WNT signaling is one of the major players in GSCs that promotes their radio- and chemoresistance. In this study we tested whether LGK974,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7b00019c762de92c41cfdda7741526