Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kahia Messaoudi"'
Autor:
Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo, Hana Raslova, Najet Debili
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked t
Externí odkaz:
https://doaj.org/article/e6244d22664d4e168a0d548e8a713d18
Autor:
Pascal Vong, Kahia Messaoudi, Nicolas Jankovsky, Cathy Gomilla, Yohann Demont, Alexis Caulier, Guillaume Jedraszak, Julien Demagny, Stefan Djordjevic, Thomas Boyer, Jean Pierre Marolleau, Jacques Rochette, Hakim Ouled‐Haddou, Loïc Garçon
Publikováno v:
Journal of cellular and molecular medicineREFERENCES.
Among histone deacetylases, HDAC6 is unusual in its cytoplasmic localization. Its inhibition leads to hyperacetylation of non-histone proteins, inhibiting cell cycle, proliferation and apoptosis. Ricolinostat (ACY-1215) is a selective inhibitor of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a9f8e8f7ed2944372c0b7ca5a42da6
https://pubmed.ncbi.nlm.nih.gov/36578217
https://pubmed.ncbi.nlm.nih.gov/36578217
Autor:
Yohann Demont, Delphine Lebon, Roggiero Lopes Dos Santos, Pascal Vong, Hakim Ouled-Haddou, Nicolas Jankovsky, Julien Demagny, Candice Carola, Jessica Platon, Alexis Caulier, Jacques Rochette, Nicolas Guillaume, Jean-Pierre Marolleau, Kahia Messaoudi, Loïc Garçon
Publikováno v:
Blood Advances
Blood Advances, 2020, 4 (22), pp.5666-5680. ⟨10.1182/bloodadvances.2020003100⟩
Blood Adv
Blood
Blood, 2019, 134 (1), ⟨10.1182/bloodadvances.2020003100⟩
Blood Advances, 2020, 4 (22), pp.5666-5680. ⟨10.1182/bloodadvances.2020003100⟩
Blood Adv
Blood
Blood, 2019, 134 (1), ⟨10.1182/bloodadvances.2020003100⟩
The Gluthation peroxidase (GPX) enzymes are part of the protective system against lipid peroxydation that includes prevention of oxydation and reduction of already oxidized lipid through enzymatic reactions catalyzed by GSH. GPX4 is one of the five G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee9e027bb44e427c16bb87718e56352
https://doi.org/10.1182/bloodadvances.2020003100
https://doi.org/10.1182/bloodadvances.2020003100
Autor:
Jean-Pierre Marolleau, Delphine Muller, Dominika Sliwa, Khadija M. Diop, Steven G. Thomas, Gérard Pierron, Alberta Palazzo, Patrick Matthias, Nathalie Droin, Isabelle Godin, Isabelle Plo, Philippe Rameau, Hana Raslova, Sylvie Souquere, Stephen P. Watson, Kahia Messaoudi, Najet Debili, William Vainchenker, Olivier Bluteau, Rameez Ishaq, Ashfaq Ali, Valérie Lapierre
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩
Thrombocytopenia is a major side effect of a new class of anticancer agents that target histone deacetylase (HDAC). Their mechanism is poorly understood. Here, we show that HDAC6 inhibition and genetic knockdown lead to a strong decrease in human pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0853dae1f6256c46924ede75a1d0b7
http://link.springer.com/article/10.1038/s41467-017-01690-2
http://link.springer.com/article/10.1038/s41467-017-01690-2
Autor:
Kahia Messaoudi, Hana Raslova, Najet Debili, Sylvie Souquere, Yunhua Chang, Valérie Lapierre, Alberta Palazzo, Gérard Pierron, Yi Zheng, Francesco Marangoni, William Vainchenker, Olivier Bluteau
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 14(12)
SummaryBackground Cytoskeleton rearrangements are essential in platelet release. The RHO small GTPase family, as regulators of the actin cytoskeleton, plays an important function in proplatelet formation. In the neuronal system, CDC42 is involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46713a9027eaae79580483a684f941b
https://pubmed.ncbi.nlm.nih.gov/27685868
https://pubmed.ncbi.nlm.nih.gov/27685868
Autor:
Siham Boukour, Hana Raslova, Leila N. Varghese, Rémi Favier, Christian Pecquet, Vitalina Gryshkova, Fabrizia Favale, Najet Debili, William Vainchenker, Roxana-Irina Albu, Paola Ballerini, Kahia Messaoudi, Isabelle Plo, Stefan N. Constantinescu, Guy Leverger, Jean-Philippe Defour, Olivier Bluteau
Publikováno v:
Blood, Vol. 128, no. 26, p. 3146-3158 (2016)
The mechanisms behind the hereditary thrombocytosis induced by the thrombopoietin (THPO) receptor MPL P106L mutant remain unknown. A complete trafficking defect to the cell surface has been reported, suggesting either weak constitutive activity or no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8031c5ccce6f1cb9f5574744d51862
https://hdl.handle.net/2078.1/180993
https://hdl.handle.net/2078.1/180993
Autor:
William Vainchenker, Jean-Philippe Defour, Fabrizia Favale, Valérie Ugo, Stefan N. Constantinescu, Jean Christophe Ianotto, Olivier Bluteau, Nathalie Droin, Christine Bellanné-Chantelot, Kahia Messaoudi, Jean Pierre Le Couédic, Hana Raslova, Isabelle Plo, Nicole Casadevall, Florence Pasquier, M'Boyba Diop, Ilyas Chachoua, Xenia Cabagnols, Christophe Marzac, Rémi Favier, Najet Debili
Publikováno v:
Blood
Blood, American Society of Hematology, 2015, 127, pp.333-342. ⟨10.1182/blood-2015-07-661983⟩
Blood, Vol. 127, no. 3, p. 333-342 (2016)
Blood, 2015, 127, pp.333-342. ⟨10.1182/blood-2015-07-661983⟩
Blood, American Society of Hematology, 2015, 127, pp.333-342. ⟨10.1182/blood-2015-07-661983⟩
Blood, Vol. 127, no. 3, p. 333-342 (2016)
Blood, 2015, 127, pp.333-342. ⟨10.1182/blood-2015-07-661983⟩
International audience; Mutations in signaling molecules of the cytokine receptor axis play a central role in myeloproliferative neoplasm (MPN) pathogenesis. Polycythemia Vera is mainly related to JAK2 mutations, whereas a wider mutational spectrum i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3b33485eb9055ca800ea07c0f7b654
https://hal.univ-brest.fr/hal-01258942
https://hal.univ-brest.fr/hal-01258942
Autor:
H Lelièvre, Ashfaq Ali, Olivier Bluteau, Isabelle Plo, Siham Boukour, L Kraus-Berthier, Hana Raslova, Larissa Lordier, S Depil, Najet Debili, William Vainchenker, Philippe Dessen, Eric Solary, Kahia Messaoudi, Philippe Rameau, A Jacquet-Bescond, Alberta Palazzo, Yann Lécluse
Publikováno v:
Cell Death & Disease
Abexinostat is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia whose mechanism is only partially understood. We have analyzed its effect a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6012eff22efec74fdf4fced42e07a8c
https://doi.org/10.1038/cddis.2013.260
https://doi.org/10.1038/cddis.2013.260