Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kahealani, Uehara"'
Autor:
Elizabeth Nunn, Natasha Jaiswal, Matthew Gavin, Kahealani Uehara, Megan Stefkovich, Karima Drareni, Ryan Calhoun, Michelle Lee, Corey D. Holman, Joseph A. Baur, Patrick Seale, Paul M. Titchenell
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101880- (2024)
Objective: Glucagon-like peptide 1 (GLP-1) receptor agonists reduce food intake, producing remarkable weight loss in overweight and obese individuals. While much of this weight loss is fat mass, there is also a loss of lean mass, similar to other app
Externí odkaz:
https://doaj.org/article/3c25c8696bac45cc8a33929b89a5909f
Autor:
Natasha Jaiswal, Matthew Gavin, Emanuele Loro, Jaimarie Sostre‐Colón, Paul A. Roberson, Kahealani Uehara, Nicole Rivera‐Fuentes, Michael Neinast, Zoltan Arany, Scot R. Kimball, Tejvir S. Khurana, Paul M. Titchenell
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 495-514 (2022)
Abstract Background Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hor
Externí odkaz:
https://doaj.org/article/762fe12f3fe3495f9e5c9957980465ca
Autor:
Kahealani Uehara, Jaimarie Sostre-Colón, Matthew Gavin, Dominic Santoleri, Kelly-Ann Leonard, René L. Jacobs, Paul M. Titchenell
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1625-1647 (2022)
Background & Aims: Dysregulation of liver lipid metabolism is associated with the development and progression of nonalcoholic fatty liver disease, a spectrum of liver diseases including nonalcoholic steatohepatitis (NASH). In the liver, insulin contr
Externí odkaz:
https://doaj.org/article/517ca050c381446883e15db8cf510b15
Autor:
Dominic Santoleri, Hee-Woong Lim, Matthew J. Emmett, Julian Stoute, Matthew J. Gavin, Jaimarie Sostre-Colón, Kahealani Uehara, Jaclyn E. Welles, Kathy Fange Liu, Mitchell A. Lazar, Paul M. Titchenell
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104410- (2022)
Summary: The insulin responsive Akt and FoxO1 signaling axis is a key regulator of the hepatic transcriptional response to nutrient intake. Here, we used global run-on sequencing (GRO-seq) to measure the nascent transcriptional response to fasting an
Externí odkaz:
https://doaj.org/article/7c71e331dbf74cd59745668fc81b8721
Autor:
Jaimarie Sostre-Colón, Kahealani Uehara, Anna E. Garcia Whitlock, Matthew J. Gavin, Jeff Ishibashi, Matthew J. Potthoff, Patrick Seale, Paul M. Titchenell
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109128- (2021)
Summary: Organismal stressors such as cold exposure require a systemic response to maintain body temperature. Brown adipose tissue (BAT) is a key thermogenic tissue in mammals that protects against hypothermia in response to cold exposure. Defining t
Externí odkaz:
https://doaj.org/article/289a3505422f4442b608e9054f528a9d
Autor:
Kahealani Uehara, Paul M. Titchenell, Paul A. Roberson, Nicole Rivera-Fuentes, Tejvir S. Khurana, Michael D. Neinast, Zoltan Arany, Scot R. Kimball, Jaimarie Sostre-Colón, Matthew Gavin, Natasha Jaiswal, Emanuele Loro
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 495-514 (2022)
Background Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hormones tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d440cf8c9327780391f9e44fbfeea4a
https://doi.org/10.1002/jcsm.12846
https://doi.org/10.1002/jcsm.12846
Autor:
Bridget S. Gosis, Shogo Wada, Chelsea Thorsheim, Kristina Li, Sunhee Jung, Joshua H. Rhoades, Yifan Yang, Jeffrey Brandimarto, Li Li, Kahealani Uehara, Cholsoon Jang, Matthew Lanza, Nathan B. Sanford, Marc R. Bornstein, Sunhye Jeong, Paul M. Titchenell, Sudha B. Biddinger, Zoltan Arany
Publikováno v:
Science (New York, N.Y.), vol 376, iss 6590
Science
Science
INTRODUCTION: As many as 100 million people in the US have nonalcoholic fatty liver disease (NAFLD), characterized by increased liver lipid accumulation, which often leads to hepatocyte injury and fibrosis, characteristics of nonalcoholic steatohepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0008f289f900d9b441ca79f71ac969
https://escholarship.org/uc/item/1pq143rx
https://escholarship.org/uc/item/1pq143rx
Autor:
Kahealani Uehara, Paul M. Titchenell
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 13(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b057863693903ed1f5cf8c0fb7aa1a1f
https://pubmed.ncbi.nlm.nih.gov/34990887
https://pubmed.ncbi.nlm.nih.gov/34990887
Autor:
Dominic, Santoleri, Hee-Woong, Lim, Matthew J, Emmett, Julian, Stoute, Matthew J, Gavin, Jaimarie, Sostre-Colón, Kahealani, Uehara, Jaclyn E, Welles, Kathy Fange, Liu, Mitchell A, Lazar, Paul M, Titchenell
Publikováno v:
iScience. 25(6)
The insulin responsive Akt and FoxO1 signaling axis is a key regulator of the hepatic transcriptional response to nutrient intake. Here, we used global run-on sequencing (GRO-seq) to measure the nascent transcriptional response to fasting and refeedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce773bade043e87e6634adbcac4f4525
https://pubmed.ncbi.nlm.nih.gov/35663017
https://pubmed.ncbi.nlm.nih.gov/35663017
Autor:
Alyssa M. Dixon, Rylee Maldonado, Chloe Adrienna Talana, Michael Weichhaus, Cassaundra Song, Kahealani Uehara
Publikováno v:
Oncology Letters
Ketogenic diets have the potential to lower glucose availability to cancer cells. However, the effect that the resulting increase in ketone bodies has on cancer cells is not fully understood. The present study explored the effect of β-hydroxybutyrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39168e38c9a2033d7afe8f315dff289
http://europepmc.org/articles/PMC7709568
http://europepmc.org/articles/PMC7709568