Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes

Autor: DiNardo, A., Gandhi, T., Heyckendorf, J., Grimm, S., Rajapakshe, K., Nishiguchi, T., Reimann, M., Kirchner, H., Kahari, J., Dlamini, Q., Lange, C., Goldmann, T., Marwitz, S., group, D., Abhimanyu, Cirillo, J., Kaufmann, S., Netea, M., van Crevel, R., Mandalakas, A., Coarfa, C.

Publikováno v: Eur Respir J
European Respiratory Journal, 60
European Respiratory Journal, 60(3):2102263. European Respiratory Society
European Respiratory Journal, 60, 3
DZIF-TB cohort study group 2022, ' Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes ', European Respiratory Journal, vol. 60, no. 3, 2102263 . https://doi.org/10.1183/13993003.02263-2021
European Respiratory Journal

BackgroundIn vitro, animal model, and clinical evidence suggests that tuberculosis is not a monomorphic disease, and that host response to tuberculosis is protean with multiple distinct molecular pathways and pathologies (endotypes). We applied unbia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae27c037e33eebd2752723d112234e6
https://hdl.handle.net/21.11116/0000-000B-5C7A-621.11116/0000-000B-5C7C-4

Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib

Autor: Kahari J. Wines, R. Nathan Daniels, James A Perkins, Mohamed Mohamud, Rebecca Durandis, Arsany A. Abouda, Gracia M. Amaya, Klarissa D. Jackson, David S Bourgeois, Samuel A. Starks

Publikováno v: Chemical research in toxicology. 31(7)

Sunitinib is a multitargeted tyrosine kinase inhibitor associated with idiosyncratic hepatotoxicity. The mechanisms of this toxicity are unknown. We hypothesized that sunitinib undergoes metabolic activation to form chemically reactive, potentially t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1990815eb1f48f97b1620840707f485c
https://pubmed.ncbi.nlm.nih.gov/29847931

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Abstract 4911: Metabolic activation of sunitinib: Implications for sunitinib-induced toxicities

Autor: Samuel A. Starks, Gracia M. Amaya, Klarissa D. Jackson, Arsany A. Abouda, R. Nathan Daniels, Rebecca Durandis, Kahari J. Wines

Publikováno v: Cancer Research. 78:4911-4911

Purpose: Sunitinib is a multi-targeted tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. However, clinical use of sunitinib is associated with potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67dd04a5801b5f0c4435f3d74d5786e6
https://doi.org/10.1158/1538-7445.am2018-4911

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