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pro vyhledávání: '"Kahan, Brennan C"'
A common concern in non-inferiority (NI) trials is that non adherence due, for example, to poor study conduct can make treatment arms artificially similar. Because intention to treat analyses can be anti-conservative in this situation, per protocol a
Externí odkaz:
http://arxiv.org/abs/2312.00494
Autor:
Kahan, Brennan C, Blette, Bryan, Harhay, Michael, Halpern, Scott, Jairath, Vipul, Copas, Andrew, Li, Fan
Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned to the study's objectives. Cluster randomised trials require additional attributes to be defined within the estimand compared to individually ra
Externí odkaz:
http://arxiv.org/abs/2303.13960
Using modified intention-to-treat as a principal stratum estimator for failure to initiate treatment
Publikováno v:
Clin Trials. 2023 Jun;20(3):269-275
Background: A common intercurrent event affecting many trials is when some participants do not begin their assigned treatment. Many trials use a modified intention-to-treat (mITT) approach, whereby participants who do not initiate treatment are exclu
Externí odkaz:
http://arxiv.org/abs/2206.10453
Results from clinical trials can be susceptible to bias if investigators choose their analysis approach after seeing trial data, as this can allow them to perform multiple analyses and then choose the method that provides the most favourable result (
Externí odkaz:
http://arxiv.org/abs/1907.04078
Akademický článek
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Akademický článek
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Autor:
Cro, Suzie1 (AUTHOR) s.cro@imperial.ac.uk, Kahan, Brennan C2 (AUTHOR), Patel, Akshaykumar3 (AUTHOR), Henley, Ania4 (AUTHOR), C, Joanna5 (AUTHOR), Hellyer, Paul5 (AUTHOR), Kumar, Manos5 (AUTHOR), Rahman, Yasmin5 (AUTHOR), Goulão, Beatriz6 (AUTHOR)
Publikováno v:
Trials. 7/6/2023, Vol. 24 Issue 1, p1-6. 6p. 1 Color Photograph, 2 Diagrams.
Autor:
Adrion, Christine, Akooji, Naseerah, Bensoussane, Hannah, Bhangu, Aneel, Bishop, Jon, Bridgwood, Bernadeta, Budgell, Eric, Caille, Agnès, Campbell, Michael, Cao, Shiwei, Chan, Claire Louise, Cheed, Versha, Collinson, Michelle, Copas, Andrew, Dixon, Stephanie N, Eldridge, Sandra, Forster, Alice S, Gill, Alicia, Giraudeau, Bruno, Girling, Alan, Glasbey, James, Goulao, Beatriz, Grantham, Kelsey L, Hackett, Simon, Hamborg, Thomas, Handley, Kelly, Harding, Monica, Hardy, Pollyanna, Hewitt, Catherine A, Hooper, Richard, Ives, Natalie, James, Kirsty, Jarvis, Christopher I, Jones, Ben, Kahan, Brennan C, Kanaan, Mona, Kasza, Jessica, Kendall, Lindsay, Kristunas, Caroline, Kusibab, Kristie, Lee, Hui-Jie, Leyrat, Clémence, Macneill, Stephanie J, Madurasinghe, Vichithranie W, Martin, James, Mbekwe Yepnang, Ariane M, McCormack, Kara, Mehta, Samir, Moerbeek, Mirjam, Moran, Kelly, Mwandigha, Lazaro Mwakesi, Ndouga Diakou, Lee Aymar, Nepogodiev, Dmitri, Omar, Omar, Pankhurst, Laura A, Parish, Alice, Patel, Smitaa, Perry, Hayley, Rombach, Ines, Simmons, Ryan, Stuart, Beth, Sun, Yongzhong, Taljaard, Monica, Tavernier, Elsa, Thompson, Jennifer A, Truong, Tracy, Vissoci, Joao Ricardo, Wagner, Adam P, Wang, Tongrong, Wang, Xueqi, Weber, Jeremy, Wilson, Nina, Wilson, Jonathan, Woolley, Rebecca, Yang, Siyun, Yang, Zidanyue, Turner, Elizabeth L *, Platt, Alyssa C, Gallis, John A, Tetreault, Kaitlin, Easter, Christina, McKenzie, Joanne E, Nash, Stephen, Forbes, Andrew B, Hemming, Karla
Publikováno v:
In The Lancet Global Health August 2021 9(8):e1163-e1168
Publikováno v:
In Journal of Clinical Epidemiology December 2020 128:29-34
Publikováno v:
Clinical Trials; Jun2024, Vol. 21 Issue 3, p363-370, 8p