Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Kah Wai Lim"'
Autor:
Justine Paris, Claire Wilhelm, Celeste Lebbé, Mohammed Elmallah, Frédéric Pamoukdjian, Audrey Héraud, Guillaume Gapihan, Aurore Van De Walle, Van Nhan Tran, Diaddin Hamdan, Clara Allayous, Maxime Battistella, Emmanuel Van Glabeke, Kah Wai Lim, Christophe Leboeuf, Sébastien Roger, Géraldine Falgarone, Anh Tuan Phan, Guilhem Bousquet
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Introduction Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified prominin‐2 (PROM2) as a biomarker predictive of distant metastases and decreased surviv
Externí odkaz:
https://doaj.org/article/440cc7f1d63047b29be1104ed18af315
Autor:
Eleni Pitsillou, Julia Liang, Katherine Ververis, Kah Wai Lim, Andrew Hung, Tom C. Karagiannis
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political, socio-economic, and public health consequences. Inhibiting replication represents an important antiviral approach, and in this context two viral proteases, the S
Externí odkaz:
https://doaj.org/article/f59f438c29274730b188467abd5c38ae
Autor:
Huan Chen, Migara Kavishka Jayasinghe, Eric Yew Meng Yeo, Zhiyuan Wu, Marco Pirisinu, Waqas Muhammad Usman, Thach Tuan Pham, Kah Wai Lim, Nhan Van Tran, Anskar Y. H. Leung, Xin Du, Qiaoxia Zhang, Anh Tuân Phan, Minh T. N. Le
Publikováno v:
Cell Proliferation. 55
Acute Myeloid Leukaemia (AML) is the most common blood cancer in adults. Although 2 out of 3 AML patients go into total remission after chemotherapies and targeted therapies, the disease recurs in 60%-65% of younger adult patients within 3 years afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8734670e729bdb5446d54b6f6070e99
https://doi.org/10.1111/cpr.13255
https://doi.org/10.1111/cpr.13255
Autor:
Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Anna-Karin Johnsson, Bruno Raposo, Ravi K. Sharma, Yunbing Shen, Zsolt Kasza, Kah Wai Lim, Karine Chemin, Gunnar Nilsson, Vivianne Malmström, Anh Tuân Phan, Fredrik Wermeling
Publikováno v:
Journal of autoimmunity. 131
Dysregulated T-cell activation is a hallmark of several autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The lymphocyte cytosolic protein 2 (LCP2), also known as SLP-76, is essential for the development and activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3107c2d3c81f6c16fd42d7ed45c5b
https://pubmed.ncbi.nlm.nih.gov/35780036
https://pubmed.ncbi.nlm.nih.gov/35780036
Publikováno v:
Biochemical and Biophysical Research Communications. 531:62-66
G-quadruplex (G4) is a non-canonical four-stranded nucleic acid structure and the RHAU helicase has been identified to have high specificity for recognition of parallel-stranded G4s. We have designed and synthesized two stapled peptide analogues of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04ed44c15c5d353c7b1028d04a25703
https://doi.org/10.1016/j.bbrc.2020.02.144
https://doi.org/10.1016/j.bbrc.2020.02.144
Publikováno v:
Nucleic Acids Research
The triple-negative breast cancer (TNBC), a subtype of breast cancer which lacks of targeted therapies, exhibits a poor prognosis. It was shown recently that the PIM1 oncogene is highly related to the proliferation of TNBC cells. A quadruplex–duple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f89711aaa22e859c540f9cac7e44a8
https://doi.org/10.1093/nar/gkaa752
https://doi.org/10.1093/nar/gkaa752
Publikováno v:
Nucleic Acids Research
Beyond the consensus definition of G-quadruplex-forming motifs with tracts of continuous guanines, G-quadruplexes harboring bulges in the G-tetrad core are prevalent in the human genome. Here, we study the incorporation of a duplex hairpin within a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb1affe73ee48c1cc26f6ae532032ea
https://doi.org/10.1093/nar/gkaa738
https://doi.org/10.1093/nar/gkaa738
A four-stranded scaffold of nucleic acids termed G-quadruplex (G4) has found growing applications in nano- and biotechnology. Propeller loops are a hallmark of the most stable intramolecular parallel-stranded G4s. To date, propeller loops have been o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cbf9560b541090633278776621b665
https://hdl.handle.net/10356/158330
https://hdl.handle.net/10356/158330
Publikováno v:
Chemical communications (Cambridge, England). 57(45)
Joining peptides and oligonucleotides offers potential benefits, but current methods remain laborious. Here we present a novel approach towards enzymatic ligation of the two modalities through the development of tag phosphoramidites that readily coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563f4dab4139bcd49e2d9e8b92b4cac9
https://pubmed.ncbi.nlm.nih.gov/34036975
https://pubmed.ncbi.nlm.nih.gov/34036975
Autor:
Fernaldo Richtia Winnerdy, Yew-Soon Ong, Kah Wai Lim, Anh Tuan Phan, Alvin T. S. Chan, Anna Korsakova
Publikováno v:
Web of Science
CHIL
CHIL
A single gene can encode for different protein versions through a process called alternative splicing. Since proteins play major roles in cellular functions, aberrant splicing profiles can result in a variety of diseases, including cancers. Alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2904eef14f6a81f74802f64e6bfc5f
https://hdl.handle.net/10356/155091
https://hdl.handle.net/10356/155091