Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Kah Leong Lim"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Synaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson’s Disease (PD) – a debilitating neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/f74d3ec6ddc0448aa7d7ac27d8cb2611
Autor:
Pazhanichamy Kalailingam, Khalilatul‐Hanisah Mohd‐Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong‐Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-16 (2023)
Abstract Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age‐linked damage to amino acid sequence NGR (Asn‐Gly‐Arg) results in “gain‐of‐function” conformatio
Externí odkaz:
https://doaj.org/article/0e78e068254840989c041da6a4477442
Autor:
Joseph D. Quick, Cristian Silva, Jia Hui Wong, Kah Leong Lim, Richard Reynolds, Anna M. Barron, Jialiu Zeng, Chih Hung Lo
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Be
Externí odkaz:
https://doaj.org/article/bc395be4598848258372b3681dfdadc4
Autor:
Kakkad Regha, Mayuri Bhargava, Abdurrahmaan Al-Mubaarak, Chou Chai, Bhav Harshad Parikh, Zengping Liu, Claudine See Wei Wong, Walter Hunziker, Kah Leong Lim, Xinyi Su
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Retinal pigment epithelial (RPE) cell dysfunction and death are characteristics of age-related macular degeneration. A promising therapeutic option is RPE cell transplantation. Development of clinical grade stem-cell derived RPE requires eff
Externí odkaz:
https://doaj.org/article/3bd7339aa071480992c9732da3df4a0f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2523 (2023)
Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder that is characterized pathologically by the loss of A9-specific dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, t
Externí odkaz:
https://doaj.org/article/f79b3edc03a6459e9a4b286e99b9b860
Autor:
Ankshita Prasad, Daniel B. Loong Teh, Agata Blasiak, Chou Chai, Yang Wu, Payam M. Gharibani, In Hong Yang, Thang T. Phan, Kah Leong Lim, Hyunsoo Yang, Xiaogang Liu, Angelo H. All
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The cellular-level effects of low/high frequency oscillating magnetic field on excitable cells such as neurons are well established. In contrast, the effects of a homogeneous, static magnetic field (SMF) on Central Nervous System (CNS) glial
Externí odkaz:
https://doaj.org/article/20df8abe2dd6465ca34a6b1abc058e93
Autor:
Yi-Ming Shao, Xiaohua Ma, Priyankar Paira, Aaron Tan, Deron Raymond Herr, Kah Leong Lim, Chee Hoe Ng, Gopalakrishnan Venkatesan, Karl-Norbert Klotz, Stephanie Federico, Giampiero Spalluto, Siew Lee Cheong, Yu Zong Chen, Giorgia Pastorin
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0188212 (2018)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. Dopamine replacement therapy remains the mains
Externí odkaz:
https://doaj.org/article/950334628e1d476da403804a28267629
Autor:
Bobby Thomas, Rainer von Coelln, Allen S. Mandir, Daniel B. Trinkaus, Mohamed H. Farah, Kah Leong Lim, Noel Y. Calingasan, M. Flint Beal, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 2, Pp 312-322 (2007)
Mutations in the parkin gene cause autosomal recessive familial Parkinson's disease (PD). Parkin-deficient mouse models fail to recapitulate nigrostriatal dopaminergic neurodegeneration as seen in PD, but produce deficits in dopaminergic neurotransmi
Externí odkaz:
https://doaj.org/article/715564389f6041478eb7c22a023b77d2
Autor:
Arada Vinaiphat, Kalailingam Pazhanchamy, Gnanasekaran JebaMercy, SoFong Cam Ngan, Melvin Khee-Shing Leow, Hee Hwa Ho, Yong-Gui Gao, Kah Leong Lim, A. Mark Richards, Dominique P.V. de Kleijn, Christopher P. Chen, Raj N. Kalaria, Jian Liu, Deborah D. O’Leary, Neil E. McCarthy, Siu Kwan Sze
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:427-442
Background: Considerable evidence links dietary salt intake with the development of hypertension, left ventricular hypertrophy, and increased risk of stroke and coronary heart disease. Despite extensive epidemiological and basic science interrogation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1992c0b12abc6d6e95e26cc4ca9ae47f
https://doi.org/10.1161/atvbaha.122.318439
https://doi.org/10.1161/atvbaha.122.318439
Autor:
Willcyn Tang, John Thundyil, Grace Gui Yin Lim, Teddy J W Tng, Sean Qing Zhang Yeow, Aditya Nair, Chou Chai, Tso-Pang Yao, Kah-Leong Lim
Publikováno v:
Human Molecular Genetics. 32:1466-1482
Abnormal lipid homeostasis has been observed in the brain of Parkinson's disease (PD) patients and experimental models, although the mechanism underlying this phenomenon is unclear. Notably, previous studies have reported that the PD-linked protein P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459703b6fb29a9d04ab9903bf0977128
https://doi.org/10.1093/hmg/ddac297
https://doi.org/10.1093/hmg/ddac297