Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kah Kooi, Ooi"'
Publikováno v:
Molecules, Vol 23, Iss 6, p 1410 (2018)
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent platinum-based complexes, commencing with cisplatin [(H3N)2PtCl2], which are effective anti-cancer chemotherapeutic drugs. While clinical applications of gold-ba
Externí odkaz:
https://doaj.org/article/5269b1a838684455abd8dfdd95f8e662
Autor:
Yiqiang Zhu, Qinwen Tai, Fa Fang, Yuanxi Wang, Jinhui Zhang, Junsheng Kang, Feng Zhong, Kok Pian Ang, Feng Gao, Kah Kooi Ooi, Liquan Cai, Yi Gao
Publikováno v:
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 38(4)
Early development of liver cancer is usually asymptomatic. The overall survival rate of patients is relatively low due to late diagnosis, despite hepatocellular carcinoma being a common diagnosis. The high mortality rate of liver cancer was due to it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f8dcf1ae75898f7d8660059125515d
https://pubmed.ncbi.nlm.nih.gov/32464002
https://pubmed.ncbi.nlm.nih.gov/32464002
Autor:
Wenzhi Zhang, Jianxin Zhang, Krystian Pluta, Małgorzata Jeleń, Chen Ming, Kok-Pian Ang, Beata Morak-Młodawska, Kah Kooi Ooi, Abdah Md Akim, Patrick Nwabueze Okechukwu
Publikováno v:
Drug Design, Development and Therapy. 11:3045-3063
The asymptomatic properties and high treatment resistance of ovarian cancer result in poor treatment outcomes and high mortality rates. Although the fundamental chemotherapy provides promising anticancer activities, it is associated with severe side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51ecb8cbef777833ebb589473e946f4
https://doi.org/10.2147/dddt.s144415
https://doi.org/10.2147/dddt.s144415
Autor:
Chien Ing Yeo, Kok Pian Ang, Kah Kooi Ooi, Abdah Md Akim, Edward R. T. Tiekink, Theventhiran Mahandaran, Hoi-Ling Seng, Yoke Kqueen Cheah
Publikováno v:
Journal of Inorganic Biochemistry. 166:173-181
Phosphanegold(I) thiolates, Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), were previously shown to be significantly cytotoxic toward HT-29 cancer cells and to induce cell death by both intrinsic and extrinsic apoptotic pathways whereby 1 acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fdbad4a8f75d39bc7c2935bb41dfa41
https://doi.org/10.1016/j.jinorgbio.2016.11.008
https://doi.org/10.1016/j.jinorgbio.2016.11.008
Publikováno v:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 121:101-108
A cationic Schiff base ligand, TSB (L) and its Zn (II) complex (1) were synthesized and characterized by using CHN, 1H-NMR, FT-IR, UV, LC–MS, and X-ray methods. Their ability to inhibit topoisomerase I, DNA cleavage activities, and cytotoxicity wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cb526a4c93fafc9b53297356cf0c80
https://doi.org/10.1016/j.saa.2013.10.084
https://doi.org/10.1016/j.saa.2013.10.084
Autor:
Kah Kooi, Ooi, Chien Ing, Yeo, Theventhiran, Mahandaran, Kok Pian, Ang, Abdah Md, Akim, Yoke-Kqueen, Cheah, Hoi-Ling, Seng, Edward R T, Tiekink
Publikováno v:
Journal of inorganic biochemistry. 166
Phosphanegold(I) thiolates, Ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92bc42399aecef2e55ace7a4e008bffa
https://pubmed.ncbi.nlm.nih.gov/27865929
https://pubmed.ncbi.nlm.nih.gov/27865929
Autor:
Yoke Kqueen Cheah, Siti Nadiah Abdul Halim, Chien Ing Yeo, Kok-Pian Ang, Kah Kooi Ooi, Edward R. T. Tiekink, Hoi-Ling Seng, Abdah Md Akim
Publikováno v:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 20(5)
The phosphanegold(I) carbonimidothioates, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), feature linear P–Au–S coordination geometries and exhibit potent in vitro cytotoxicity against HT-29 colon cancer cells in both monolayer and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7207d387c95eaf7f81c36151dc2b852f
https://pubmed.ncbi.nlm.nih.gov/26003312
https://pubmed.ncbi.nlm.nih.gov/26003312
Autor:
Yoke Kqueen Cheah, Siti Nadiah Abdul Halim, Yee Seng Tan, Edward R. T. Tiekink, Abdah Md Akim, Kok Pian Ang, Kah Kooi Ooi, Hoi-Ling Seng
Publikováno v:
Journal of inorganic biochemistry. 150
In the solid state each of three binuclear zinc dithiocarbamates bearing hydroxyethyl groups, {Zn[S2CN(R)CH2CH2OH]2}2 for R = iPr (1), CH2CH2OH (2), and Me (3), and an all alkyl species, [Zn(S2CNEt2)2]2 (4), features a centrosymmetric {ZnSCS}2 core w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c7a465f6d2a2d4801d9a3651bef5c4
https://pubmed.ncbi.nlm.nih.gov/26086852
https://pubmed.ncbi.nlm.nih.gov/26086852
Autor:
Yoke Kqueen Cheah, Dayang Hazwani Abang Ishak, Abdah Md Akim, Siti Nadiah Abdul Halim, Norshariza Nordin, Kah Kooi Ooi, Hoi-Ling Seng, Edward R. T. Tiekink, Kok-Pian Ang
Publikováno v:
Journal of inorganic biochemistry. 130
The compound with R = CH2CH3 in Bi(S2CNR2)3 (1) is highly cytotoxic against a range of human carcinoma, whereas that with R = CH2CH2OH (2) is considerably less so. Both 1 and 2 induce apoptosis in HepG2 cells with some evidence for necrosis induced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e1a1bd9321315e1325094686e98efa
https://pubmed.ncbi.nlm.nih.gov/24176918
https://pubmed.ncbi.nlm.nih.gov/24176918
Autor:
Jianxin Zhang, Chen Ming, Wenzhi Zhang, Okechukwu, Patrick, Morak-Młodawska, Beata, Pluta, Krystian, Jeleń, Małgorzata, Akim, Abdah Md, Kok-Pian Ang, Kah Kooi Ooi
Publikováno v:
Drug Design, Development & Therapy; 2017, Vol. 11, p3045-3063, 19p