Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kah Fei Wan"'
Autor:
David Estoppey, Chia Min Lee, Marco Janoschke, Boon Heng Lee, Kah Fei Wan, Hongping Dong, Philippe Mathys, Ireos Filipuzzi, Tim Schuhmann, Ralph Riedl, Thomas Aust, Olaf Galuba, Gregory McAllister, Carsten Russ, Martin Spiess, Tewis Bouwmeester, Ghislain M.C. Bonamy, Dominic Hoepfner
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 451-460 (2017)
Summary: Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat with no US Food and Drug Administration (FDA)-approved vaccination or specific antiviral treatment available. Here, we present the discovery of an a
Externí odkaz:
https://doaj.org/article/e28693aa57094699a61e6dab252c932b
Autor:
Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005737 (2016)
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5). This essential enzymatic act
Externí odkaz:
https://doaj.org/article/9bed2e761e8c4eac932cd102650b701a
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Autor:
Alex Chao, Boon Heng Lee, Kah Fei Wan, David Beer, Peter Gedeck, Thierry T. Diagana, Jeremy J. Selva, Bin Zou, Ujjini H. Manjunatha, Ghislain M. C. Bonamy
Publikováno v:
ACS Infectious Diseases. 4:635-645
Cryptosporidiosis is a diarrheal disease predominantly caused by Cryptosporidium parvum ( Cp) and Cryptosporidium hominis ( Ch), apicomplexan parasites which infect the intestinal epithelial cells of their human hosts. The only approved drug for cryp
Autor:
Chia Min Lee, Kah Fei Wan, Ralph Riedl, Marco Janoschke, Ghislain M. C. Bonamy, Tewis Bouwmeester, Olaf Galuba, Hongping Dong, Philippe Mathys, Tim Schuhmann, David Estoppey, Martin Spiess, Carsten Russ, Dominic Hoepfner, Ireos Filipuzzi, Boon Heng Lee, Gregory McAllister, Thomas Aust
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 451-460 (2017)
Summary: Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat with no US Food and Drug Administration (FDA)-approved vaccination or specific antiviral treatment available. Here, we present the discovery of an a
Autor:
Hongping Dong, Bryan K. S. Yeung, Ratna Karuna, Bin Zou, Trixie Wagner, Hui-Quan Yeo, Cyrille Kounde, Oliver Simon, Kah Fei Wan, Qing-Yin Wang, Ghislain M. C. Bonamy, Fumiaki Yokokawa, Ina Dix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1385-1389
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the i
Autor:
Julien Lescar, Feng Gu, Kah Fei Wan, Francesca Blasco, CongBao Kang, Wai Ling Chan, Wei Liu, Paul W. Smith, Agatha Susila, Bin Zou, Qing Yin Wang, K.L. Yeo, Mei Ding, Chao Shan, Andy M. Yip, Haoying Xu, Hongping Dong, Jing Zou, Suresh B. Lakshminarayana, Ratna Karuna, Pei Yong Shi, Peck Gee Seah
Publikováno v:
Journal of Virology. 89:8233-8244
The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that
Autor:
Hao Ying Xu, Wei Liu, Feng Gu, Bin Zou, Wai Ling Chan, Paul W. Smith, Kah Fei Wan, Ratna Karuna, Agatha Susila, Peck Gee Seah, Andy Yip, Pei Yong Shi, Trixie Wagner, Thierry T. Diagana, Qing Yin Wang, Alex Chao, Mei Ding, Hongping Dong, Seh Yong Leong, Francesca Blasco, Katherine Chan, Shahul Nilar, Ina Dix
Publikováno v:
ACS Medicinal Chemistry Letters. 6:344-348
Spiropyrazolopyridone 1 was identified, as a novel dengue virus (DENV) inhibitor, from a DENV serotype 2 (DENV-2) high-throughput phenotypic screen. As a general trend within this chemical class, chiral resolution of the racemate revealed that R enan
Autor:
Fumiaki Yokokawa, Kah Fei Wan, Tingjin Sherryl Soh, Julien Lescar, Timothy E. Benson, Shahul Nilar, Ujjini H. Manjunatha, Christian G. Noble, Rishi Arora, Pei Yong Shi, Siew Pheng Lim, Xuping Xie, Abbas El Sahili, Grace Kar Yarn Chan, Cheah Chen Seh, Hongping Dong
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, Vol 12, Iss 8, p e1005737 (2016)
PLoS Pathogens, Public Library of Science, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, 2016, 12 (8), pp.e1005737. ⟨10.1371/journal.ppat.1005737⟩
PLoS Pathogens, Vol 12, Iss 8, p e1005737 (2016)
Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5). This essential enzymatic act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034136f5f16028951bdce66f86164cb2
https://hal.sorbonne-universite.fr/hal-01393322
https://hal.sorbonne-universite.fr/hal-01393322
Publikováno v:
Molecular Cell. 37(6):768-783
Inhibition of apoptotic response of host cells during an early phase of infection is a strategy used by many enteroinvasive bacterial pathogens to enhance their survival. Here, we report the identification of a soluble form of the pilus protein FimA