Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Kah‐Leong Lim"'
Autor:
Wenli Cui, Jing Yang, Chuanyun Tu, Ziting Zhang, Huifang Zhao, Yan Qiao, Yanqiu Li, Wulin Yang, Kah-Leong Lim, Quanhong Ma, Chengwu Zhang, Li Lu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-15 (2024)
Abstract Seipin is one key mediator of lipid metabolism that is highly expressed in adipose tissues as well as in the brain. Lack of Seipin gene, Bscl2, leads to not only severe lipid metabolic disorders but also cognitive impairments and motor disab
Externí odkaz:
https://doaj.org/article/ac9a3cbcf6594d67ac8d3f56c6f4cfd4
Autor:
Teddy J. W. Tng, Barbara Wing Yan Wong, Esther H. Y. Sim, Eng King Tan, Wilson W. B. Goh, Kah-Leong Lim
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-21 (2024)
Abstract Parkinson’s disease (PD) is a prevalent neurodegenerative disorder affecting millions of elderly individuals worldwide. Clinically, PD is diagnosed based on the presentation of motoric symptoms. Other methods such as F-DOPA PET scan or α-
Externí odkaz:
https://doaj.org/article/1f023a8c5dfc4c8085e7636fbddf049a
Autor:
Dylan Hong Zheng Koh, Tomoki Naito, Minyoung Na, Yee Jie Yeap, Pritisha Rozario, Franklin L. Zhong, Kah-Leong Lim, Yasunori Saheki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including neurodegenerative disorders. While regulated transport of a spe
Externí odkaz:
https://doaj.org/article/91c41d6838114740a6485960bdefe6bb
Autor:
Jing Yang, Na Yang, Huifang Zhao, Yan Qiao, Yanqiu Li, Chunfang Wang, Kah-Leong Lim, Chengwu Zhang, Wulin Yang, Li Lu
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Background Lipodystrophy-associated metabolic disorders caused by Seipin deficiency lead to not only severe lipodystrophy but also neurological disorders. However, the underlying mechanism of Seipin deficiency-induced neuropathy is not well
Externí odkaz:
https://doaj.org/article/81a5fa7d3a8f4d5f9e79172579110faf
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background Aberrant aggregation of α-synuclein (α-syn) is a key pathological feature of Parkinson’s disease (PD), but the precise role of intestinal α-syn in the progression of PD is unclear. In a number of genetic Drosophila models of
Externí odkaz:
https://doaj.org/article/e56eb6790d5d42038861326d9d0a3a33
Autor:
Yue Wu, Zhongting Zhao, Naidi Yang, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu, Changmin Yu, Chengwu Zhang
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 153 (2023)
Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains inc
Externí odkaz:
https://doaj.org/article/effd19daa13f4d6d830af4fb88911f98
Autor:
Liting Hang, Ziyin Wang, Aaron S.C. Foo, Geraldine W.Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Publikováno v:
Neurobiology of Disease, Vol 161, Iss , Pp 105560- (2021)
Emerging studies implicate energy dysregulation as an underlying trigger for Parkinson's disease (PD), suggesting that a better understanding of the molecular pathways governing energy homeostasis could help elucidate therapeutic targets for the dise
Externí odkaz:
https://doaj.org/article/e681f29124b6458790dfeedd53c81d8a
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
As the main driver of energy production in eukaryotes, mitochondria are invariably implicated in disorders of cellular bioenergetics. Given that dopaminergic neurons affected in Parkinson’s disease (PD) are particularly susceptible to energy fluctu
Externí odkaz:
https://doaj.org/article/e2f0fe6b6f7a4c9eaf1c412ef977e09c
Autor:
Frederick C. Nucifora, Leslie G. Nucifora, Chee-Hoe Ng, Nicolas Arbez, Yajuan Guo, Elaine Roby, Vered Shani, Simone Engelender, Dong Wei, Xiao-Fang Wang, Tianxia Li, Darren J. Moore, Olga Pletnikova, Juan C. Troncoso, Akira Sawa, Ted M. Dawson, Wanli Smith, Kah-Leong Lim, Christopher A. Ross
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Mutations in LRRK2 are linked to Parkinson’s Disease. Here, the authors identify WSB1 as a LRRK2 interacting protein and find that it promotes LRRK2 aggregation in primary neurons and drosophila models via ubiquitin K27 and K29 linkages.
Externí odkaz:
https://doaj.org/article/0422154ec8e94aaeacb24bc6f49b8afd
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 8, Pp 1270-1272 (2017)
Externí odkaz:
https://doaj.org/article/5086f18c630f4ee1a6be756cd057ccb8