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Ferroptosis in health and disease.

Autor: Berndt C; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Alborzinia H; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Amen VS; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Ayton S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia., Barayeu U; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany; Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan., Bartelt A; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany., Bayir H; Department of Pediatrics, Columbia University, New York City, NY, USA., Bebber CM; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Birsoy K; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Böttcher JP; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Brabletz S; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brabletz T; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brown AR; Department of Biological Sciences, Columbia University, New York City, NY, USA., Brüne B; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Bulli G; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany., Bruneau A; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Chen Q; College of Life Sciences, Nankai University, Tianjin, China., DeNicola GM; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA., Dick TP; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Distéfano A; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Engler JB; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Esser-von Bieren J; Department of Immunobiology, Université de Lausanne, Switzerland., Fedorova M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Friedmann Angeli JP; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Fuhrmann DC; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., García-Sáez AJ; Institute for Genetics, CECAD, University of Cologne, Germany; Max Planck Institute of Biophysics, Frankfurt/Main, Germany., Garbowicz K; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Götz M; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center Munich, Germany., Gu W; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Hammerich L; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Hassannia B; Department of Biomedical Sciences, University of Antwerp, Belgium., Jiang X; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Jeridi A; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany, Member of the German Center for Lung Research (DZL)., Kang YP; College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea., Kagan VE; School of Public Health, University of Pittsburgh, PA, USA., Konrad DB; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Kotschi S; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Lei P; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Le Tertre M; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Lev S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Liang D; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Linkermann A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA., Lohr C; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Lorenz S; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Methner A; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Michalke B; Research Unit Analytical Biogeochemistry, Helmholtz Center Munich, Germany., Milton AV; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Min J; School of Medicine, Zhejiang University, Hangzhou, China., Mishima E; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Müller S; Cellular and Chemical Biology, Institut Curie, Paris, France., Motohashi H; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Muckenthaler MU; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Murakami S; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Olzmann JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA., Pagnussat G; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Pan Z; School of Life Sciences, Westlake University, Hangzhou, China., Papagiannakopoulos T; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Pedrera Puentes L; Institute for Genetics, CECAD, University of Cologne, Germany., Pratt DA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada., Proneth B; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Ramsauer L; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Rodriguez R; Cellular and Chemical Biology, Institut Curie, Paris, France., Saito Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan., Schmidt F; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Schmitt C; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Schulze A; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., Schwab A; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Schwantes A; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Soula M; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Spitzlberger B; Department of Immunobiology, Université de Lausanne, Switzerland; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany., Stockwell BR; Department of Biological Sciences, Columbia University, New York City, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Chemistry, Columbia University, New York, NY, USA., Thewes L; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Thorn-Seshold O; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Toyokuni S; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan; Center for Integrated Sciences of Low-temperature Plasma Core Research (iPlasma Core), Tokai National Higher Education and Research System, Nagoya, Japan., Tonnus W; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany., Vandenabeele P; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vanden Berghe T; Department of Biomedical Sciences, University of Antwerp, Belgium; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Venkataramani V; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Germany., Vogel FCE; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., von Karstedt S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Germany., Wang F; School of Medicine, Zhejiang University, Hangzhou, China., Westermann F; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Wientjens C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wilhelm C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wölk M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Wu K; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Yang X; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Yu F; College of Life Sciences, Nankai University, Tianjin, China., Zou Y; School of Life Sciences, Westlake University, Hangzhou, China; Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany. Electronic address: marcus.conrad@helmholtz-muenchen.de.

Publikováno v: Redox biology [Redox Biol] 2024 Sep; Vol. 75, pp. 103211. Date of Electronic Publication: 2024 May 30.

Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes.

Autor: Yamada K; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Respiratory Medicine, Graduate School of Medicine, Osaka Metropolitan University, Osaka, 545-8585, Japan., St Croix C; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Stolz DB; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Tyurina YY; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Tyurin VA; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Bradley LR; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Kapralov AA; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Deng Y; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Rheumatology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China., Zhou X; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Wei Q; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Liao B; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Otolaryngology-Head & Neck Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China., Fukuda N; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan., Sullivan M; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Trudeau J; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Ray A; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA., Kagan VE; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Zhao J; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA. JinmingZhao@pitt.edu., Wenzel SE; Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA. swenzel@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 10; Vol. 15 (1), pp. 5818. Date of Electronic Publication: 2024 Jul 10.

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.

Autor: Chen X; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China., Tsvetkov AS; Department of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USA., Shen HM; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China., Isidoro C; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy., Ktistakis NT; Babraham Institute, Cambridge, UK., Linkermann A; Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA., Koopman WJH; Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands., Simon HU; Institute of Pharmacology, University of Bern, Bern, Switzerland.; Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany., Galluzzi L; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA., Luo S; Peninsula Medical School, University of Plymouth, Plymouth, UK., Xu D; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China., Gu W; Institute for Cancer Genetics, and Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Peulen O; Metastasis Research Laboratory, GIGA Cancer-University of Liège, Liège, Belgium., Cai Q; Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA., Rubinsztein DC; Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK., Chi JT; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA., Zhang DD; Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA., Li C; Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China., Toyokuni S; Department of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan., Liu J; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China., Roh JL; Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea., Dai E; The Second Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China., Juhasz G; Biological Research Center, Institute of Genetics, Szeged, Hungary.; Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary., Liu W; Department of Orthopedics, Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, China., Zhang J; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Yang M; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.; Hunan Clinical Research Center of Pediatric Cancer, Changsha, China., Liu J; DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China., Zhu LQ; Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zou W; Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, USA., Piacentini M; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.; National Institute for Infectious Diseases IRCCS 'Lazzaro Spallanzani', Rome, Italy., Ding WX; Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA., Yue Z; Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Xie Y; Department of Oncology, Central South University, Changsha, Hunan, China., Petersen M; Functional genomics, Department of Biology, Copenhagen University, Denmark., Gewirtz DA; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA., Mandell MA; Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, USA., Chu CT; Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sinha D; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Wilmer Eye lnstitute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Eftekharpour E; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer, Villejuif, France; Gustave Roussy Cancer, Villejuif, France., Zhivotovsky B; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Europe.; Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.; Engelhardt Institute of Molecular Biology, Moscow, Russia., Besteiro S; LPHI, University Montpellier, CNRS, Montpellier, France.; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France., Gabrilovich DI; AstraZeneca, Early Oncology R&D, Gaithersburg, MD, USA., Kim DH; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Kagan VE; Department of Environmental Health, University of Pittsburgh, Pittsburgh, PA, USA., Bayir H; Department of Pediatrics, Columbia University, New York, USA., Chen GC; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan., Ayton S; Florey Institute, University of Melbourne, Parkville, Australia., Lünemann JD; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany., Komatsu M; Department of Physiology, Juntendo University School of Medicine, Bunkyo-ku Tokyo, Japan., Krautwald S; Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany., Loos B; Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa., Baehrecke EH; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Wang J; Department of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Thoracic Oncology Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; College of Medical Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Lane JD; School of Biochemistry, University of Bristol, Bristol, UK., Sadoshima J; Rutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, USA., Yang WS; Department of Biological Sciences, St. John's University, New York City, NY, USA., Gao M; The HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Münz C; Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Thumm M; Department of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany., Kampmann M; Department of Biochemistry & Biophysics, University of California, San Francisco, USA.; Institute for Neurodegenerative Diseases, University of California, San Francisco, USA., Yu D; Faculty of Medicine, Frazer Institute, University of Queensland, Brisbane, Australia.; Faculty of Medicine, Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, University of Queensland, Brisbane, Australia., Lipinski MM; Department of Anesthesiology & Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA., Jones JW; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA., Jiang X; Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zeh HJ; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA., Kang R; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA., Klionsky DJ; Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Kroemer G; Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer, Villejuif, France; Gustave Roussy Cancer, Villejuif, France.; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France., Tang D; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

Publikováno v: Autophagy [Autophagy] 2024 Jun; Vol. 20 (6), pp. 1213-1246. Date of Electronic Publication: 2024 Mar 24.

PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.

Autor: Yang X; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Wang Z; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Samovich SN; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA., Kapralov AA; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Amoscato AA; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Tyurin VA; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Dar HH; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Li Z; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Duan S; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Kon N; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Chen D; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Tycko B; Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA., Zhang Z; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA; Department of Pediatrics and Department of Genetics and Development, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Jiang X; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Bayir H; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15224, USA., Stockwell BR; Department of Chemistry, Columbia University, New York, NY 10027, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA., Kagan VE; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Gu W; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: wg8@cumc.columbia.edu.

Publikováno v: Cell metabolism [Cell Metab] 2024 Apr 02; Vol. 36 (4), pp. 762-777.e9. Date of Electronic Publication: 2024 Feb 02.