Výsledky vyhledávání - "Kafa, Walweel"

The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene

Autor: Kafa Walweel, Derek R. Laver, Ye Win Oo

Publikováno v: Clinical and Experimental Pharmacology and Physiology. 44:135-142

Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31507866d4904ffccc3f6aae55f72327
https://doi.org/10.1111/1440-1681.12669

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Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels

Autor: Walter J. Chazin, Kafa Walweel, Derek R. Laver, Dirk F. van Helden, Ye Wint Oo, Christopher N. Johnson, Cris dos Remedios, Nieves Gomez-Hurtado, Nicole A. Beard, Bjorn C. Knollmann

Publikováno v: Journal of the American College of Cardiology. 70:115-117

Calmodulin (CaM) is a calcium-binding protein that can directly inhibit cardiac ryanodine receptor calcium release channels (ryanodine receptor 2 [RyR2]) [(1)][1]. CaM mutations can cause an autosomal-dominant form of catecholaminergic polymorphic ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6a0b4a4bce0a60751d8b8789ef9a0d
https://doi.org/10.1016/j.jacc.2017.04.055

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Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum

Autor: Peter C. M. Molenaar, Mohammad S. Imtiaz, Nicole A. Beard, Chris G. dos Remedios, Dirk F. van Helden, Derek R. Laver, Angela F. Dulhunty, Jiao Li, Anthony W. Quail, Kafa Walweel

Publikováno v: Journal of General Physiology. 144:263-271

Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca(2+) and Mg(2+) plays a key role in determining cardiac contraction and rhythmicity, but their role in regulating the human RyR2 remains poorly defined. The Ca(2+)- and Mg(2+)-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f925aafe06c0816fcb98ca87b25a9f5c
https://doi.org/10.1085/jgp.201311157

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Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

Autor: Donald M. Bers, Razvan L. Cornea, Derek R. Laver, Yi Yang, Laetitia Pereira, Walter J. Chazin, Hyun Seok Hwang, Florentin R. Nitu, Kafa Walweel, Christopher N. Johnson, Bjorn C. Knollmann, Michela Faggioni, Alfred L. George

Publikováno v: Hwang, HS; Nitu, FR; Yang, Y; Walweel, K; Pereira, L; Johnson, CN; et al.(2014). Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circulation Research, 114(7), 1114-1124. doi: 10.1161/CIRCRESAHA.114.303391. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5bm5z1rc
Circulation research, vol 114, iss 7

Rationale: Calmodulin (CaM) mutations are associated with an autosomal dominant syndrome of ventricular arrhythmia and sudden death that can present with divergent clinical features of catecholaminergic polymorphic ventricular tachycardia (CPVT) or l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0687f277342a969451ac048d67b5b1
https://doi.org/10.1161/circresaha.114.303391

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RyR2 Inhibition by Dantrolene Requires both Calmodulin and FKBP12.6

Autor: N. Gomez-Hurtado, Bjorn C. Knollmann, Derek R. Laver, Nicole A. Beard, Ye Wint Oo, Kafa Walweel

Publikováno v: Heart, Lung and Circulation. 27:S191

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2db5294f7a91dabb9cef4ff085af26d9
https://doi.org/10.1016/j.hlc.2018.06.334

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Essential Role of Calmodulin in RyR Inhibition by Dantrolene

Autor: Nieves Gomez-Hurtado, Dirk F. van Helden, Kafa Walweel, Derek R. Laver, Mohammad S. Imtiaz, Ye Win Oo, Bjorn C. Knollmann

Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca(2+) release. Although dantrolene inhibits Ca(2+) release from the sarc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99779739f8de0b9034abf9db49672423
https://europepmc.org/articles/PMC4468648/

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Calmodulin Regulation of Ryanodine Receptors (RyR2) Depends on RyR2 Phosphorylation at Residues S2808 and S2814

Autor: Nieves Gomez-Hurtado, Derek R. Laver, Kafa Walweel, Bjorn C. Knollmann

Publikováno v: Biophysical Journal. 112:232a

Introduction: Calmodulin (CaM) is a calcium-binding protein that regulates target proteins directly or via their regulatory kinases. CaM binds RyR2 and forms part of the RyR2 macromolecular complex that includes Protein Kinase A (PKA), CaM-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f028faab444ab8b54af6b0b1a6c42354
https://doi.org/10.1016/j.bpj.2016.11.1275

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