T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19.

Autor: Zonozi R; Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA., Walters LC; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA., Shulkin A; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Naranbhai V; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.; Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa.; Monash University, Melbourne, VIC 3022, Australia., Nithagon P; Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA., Sauvage G; Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA., Kaeske C; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Cosgrove K; Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA., Nathan A; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Program in Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Boston, MA 02115, USA., Tano-Menka R; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Gayton AC; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Getz MA; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Senjobe F; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Worrall D; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA., Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Fromson C; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Montesi SB; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Rao DA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Sparks JA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Wallace ZS; Division of Rheumatology, Massachusetts General Hospital, Boston, MA 02114, USA., Farmer JR; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Division of Allergy and Inflammation, Beth Israel Lahey Health, Boston, MA 02215, USA., Walker BD; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa.; Broad Institute, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Institute for Medical Engineering and Science and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Charles RC; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA., Laliberte K; Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA., Niles JL; Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, MA 02114, USA., Gaiha GD; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Nov 29; Vol. 15 (724), pp. eadh4529. Date of Electronic Publication: 2023 Nov 29.