Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Kaelin D"'
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Autor:
Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin
Externí odkaz:
https://doaj.org/article/88d19ef3aa294ad58ab797d027080ed5
Autor:
Manoj K. Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J. Harris, John T. Evans, Jordan T.B. Stariha, Udit Dalwadi, Kaelin D. Fleming, Harish Ranga-Prasad, Calvin K. Yip, Roger L. Williams, Scott D. Hansen, John E. Burke
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112172- (2023)
Summary: Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein-coupled receptors (GPCRs) and Ras. Using a combination
Externí odkaz:
https://doaj.org/article/adaec01d7c824f20bc3e5572c80805c4
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The essential protein kinase PDK1 is activated by phospoinositide-mediated dimerization and trans-autophosphorylation. Here, the authors show that in the absence of PIP3 or PI(3,4)P2 phosphoinositides, PDK1 is maintained in an inactive, autoinhibited
Externí odkaz:
https://doaj.org/article/12cf17b4eda64639a643128b30b79f8c
Autor:
Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for m
Externí odkaz:
https://doaj.org/article/3b33c35036634db9ae0d9e4f5089b84e
Autor:
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke
Publikováno v:
eLife, Vol 10 (2021)
Class I Phosphoinositide 3-kinases (PI3Ks) are master regulators of cellular functions, with the class IB PI3K catalytic subunit (p110γ) playing key roles in immune signalling. p110γ is a key factor in inflammatory diseases and has been identified
Externí odkaz:
https://doaj.org/article/7f784cecc93e43a98a6ad064bf0019ce
Autor:
Rathinaswamy, Manoj K., Jenkins, Meredith L., Duewell, Benjamin R., Zhang, Xuxiao, Harris, Noah J., Evans, John T., Stariha, Jordan T.B., Dalwadi, Udit, Fleming, Kaelin D., Ranga-Prasad, Harish, Yip, Calvin K., Williams, Roger L., Hansen, Scott D., Burke, John E.
Publikováno v:
In Cell Reports 28 March 2023 42(3)
Autor:
Truebestein, Linda, Hornegger, Harald, Anrather, Dorothea, Hartl, Markus, Fleming, Kaelin D., Stariha, Jordan T. B., Pardon, Els, Steyaert, Jan, Burke, John E., Leonard, Thomas A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2021 Aug . 118(33), 1-11.
Externí odkaz:
https://www.jstor.org/stable/27074815
Publikováno v:
In Journal of Biological Chemistry August 2021 297(2)
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Akademický článek
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