Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kaela M. Varberg"'
Autor:
Kaela M. Varberg, Esteban M. Dominguez, Boryana Koseva, Joseph M. Varberg, Ross P. McNally, Ayelen Moreno-Irusta, Emily R. Wesley, Khursheed Iqbal, Warren A. Cheung, Carl Schwendinger-Schreck, Craig Smail, Hiroaki Okae, Takahiro Arima, Michael Lydic, Kristin Holoch, Courtney Marsh, Michael J. Soares, Elin Grundberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited. Here, we map the transcriptome and epi
Externí odkaz:
https://doaj.org/article/32af357bf3224b598ca6146e0d2f58e5
Autor:
Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Establishment of the hemochorial uterine–placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly unders
Autor:
Kaela M. Varberg, Ayelen Moreno-Irusta, Allynson Novoa, Boryana Koseva, Brynne Musser, Joseph M. Varberg, Jeremy P. Goering, Irfan Saadi, Hiroaki Okae, Takahiro Arima, John Williams, Elin Grundberg, Margareta D. Pisarska, Michael J. Soares
Human trophoblast stem (TS) cells are an informative in vitro model for the generation and testing of biologically meaningful hypotheses. The goal of this project was to derive patient-specific TS cell lines from clinically available chorionic villus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a728f50a8156c4e1d275448c412e22f
https://doi.org/10.1101/2022.12.07.22283218
https://doi.org/10.1101/2022.12.07.22283218
Autor:
Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Establishment of the hemochorial uterine-placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6505b1df5f699c83fa6ce13b35aef78
https://doi.org/10.1101/2022.06.15.496287
https://doi.org/10.1101/2022.06.15.496287
Autor:
Kaela M. Varberg, Esteban M. Dominguez, Boryana Koseva, Joseph M. Varberg, Ross P. McNally, Ayelen Moreno-Irusta, Emily R. Wesley, Khursheed Iqbal, Warren A. Cheung, Carl Schwendinger-Schreck, Craig Smail, Hiroaki Okae, Takahiro Arima, Michael Lydic, Kristin Holoch, Courtney Marsh, Michael J. Soares, Elin Grundberg
The extravillous trophoblast (EVT) cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving EVT cell development is limited. Here, we mapped the transcriptome and epigenome landscape as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d45e05f0320cb3f160f5b86eb7b9654
https://doi.org/10.1101/2022.05.25.22275520
https://doi.org/10.1101/2022.05.25.22275520
Autor:
Masanaga Muto, Damayanti Chakraborty, Kaela M. Varberg, Ayelen Moreno-Irusta, Khursheed Iqbal, Regan L. Scott, Ross P. McNally, Ruhul H. Choudhury, John D. Aplin, Hiroaki Okae, Takahiro Arima, Shoma Matsumoto, Masatsugu Ema, Alan E. Mast, Elin Grundberg, Michael J. Soares
Publikováno v:
Proc Natl Acad Sci U S A
Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell and mutant rat models to investigate regulatory mechanisms controlling tro
Autor:
Jay L. Vivian, Kaela M. Varberg, John D. Aplin, Ruhul Choudhury, Masanaga Muto, Michael J. Soares, Mikaela E Simon, Elin Grundberg, Margaret Gibson, Keisuke Kozai, Takahiro Arima, Khursheed Iqbal, Hiroaki Okae, Regan L. Scott, Rebecca Biswell
Publikováno v:
Proc Natl Acad Sci U S A
Invasive trophoblast cells are critical to spiral artery remodeling in hemochorial placentation. Insufficient trophoblast cell invasion and vascular remodeling can lead to pregnancy disorders including preeclampsia, preterm birth, and intrauterine gr
Publikováno v:
Biology of Reproduction. 99:196-211
Placentation is a reproductive adaptation that permits fetal growth and development within the protected confines of the female reproductive tract. Through this important role, the placenta also determines postnatal health and susceptibility to disea
Publikováno v:
Placenta. 112:e5
Publikováno v:
Journal of Cellular Physiology. 232:1885-1892
Diabetes mellitus (DM) during pregnancy has long-lasting implications for the fetus, including cardiovascular morbidity. Previously, we showed that endothelial colony forming cells (ECFCs) from DM human pregnancies have decreased vasculogenic potenti