Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kaela M Varberg"'
Autor:
Jackson Nteeba, Kaela M Varberg, Regan L Scott, Mikaela E Simon, Khursheed Iqbal, Michael J Soares
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction The hemochorial placenta provides a critical barrier at the maternal–fetal interface to modulate maternal immune tolerance and enable gas and nutrient exchange between mother and conceptus. Pregnancy outcomes are adversely affected by
Externí odkaz:
https://doaj.org/article/8157ce38174f4bfd9fba66b62d9fd6b2
Autor:
Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Establishment of the hemochorial uterine–placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237d5cee2f611f9f8b96c27e0ecb177f
https://doi.org/10.1073/pnas.2213622120
https://doi.org/10.1073/pnas.2213622120
Autor:
Kaela M. Varberg, Ayelen Moreno-Irusta, Allynson Novoa, Boryana Koseva, Brynne Musser, Joseph M. Varberg, Jeremy P. Goering, Irfan Saadi, Hiroaki Okae, Takahiro Arima, John Williams, Elin Grundberg, Margareta D. Pisarska, Michael J. Soares
Human trophoblast stem (TS) cells are an informative in vitro model for the generation and testing of biologically meaningful hypotheses. The goal of this project was to derive patient-specific TS cell lines from clinically available chorionic villus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a728f50a8156c4e1d275448c412e22f
https://doi.org/10.1101/2022.12.07.22283218
https://doi.org/10.1101/2022.12.07.22283218
Autor:
Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Establishment of the hemochorial uterine-placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6505b1df5f699c83fa6ce13b35aef78
https://doi.org/10.1101/2022.06.15.496287
https://doi.org/10.1101/2022.06.15.496287
Autor:
Kaela M. Varberg, Esteban M. Dominguez, Boryana Koseva, Joseph M. Varberg, Ross P. McNally, Ayelen Moreno-Irusta, Emily R. Wesley, Khursheed Iqbal, Warren A. Cheung, Carl Schwendinger-Schreck, Craig Smail, Hiroaki Okae, Takahiro Arima, Michael Lydic, Kristin Holoch, Courtney Marsh, Michael J. Soares, Elin Grundberg
The extravillous trophoblast (EVT) cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving EVT cell development is limited. Here, we mapped the transcriptome and epigenome landscape as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d45e05f0320cb3f160f5b86eb7b9654
https://doi.org/10.1101/2022.05.25.22275520
https://doi.org/10.1101/2022.05.25.22275520
Autor:
Masanaga Muto, Damayanti Chakraborty, Kaela M. Varberg, Ayelen Moreno-Irusta, Khursheed Iqbal, Regan L. Scott, Ross P. McNally, Ruhul H. Choudhury, John D. Aplin, Hiroaki Okae, Takahiro Arima, Shoma Matsumoto, Masatsugu Ema, Alan E. Mast, Elin Grundberg, Michael J. Soares
Publikováno v:
Proc Natl Acad Sci U S A
Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell and mutant rat models to investigate regulatory mechanisms controlling tro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e518bb825f746938bcad7edf1ac7b0
https://pubmed.ncbi.nlm.nih.gov/34876522
https://pubmed.ncbi.nlm.nih.gov/34876522
Autor:
Jay L. Vivian, Kaela M. Varberg, John D. Aplin, Ruhul Choudhury, Masanaga Muto, Michael J. Soares, Mikaela E Simon, Elin Grundberg, Margaret Gibson, Keisuke Kozai, Takahiro Arima, Khursheed Iqbal, Hiroaki Okae, Regan L. Scott, Rebecca Biswell
Publikováno v:
Proc Natl Acad Sci U S A
Invasive trophoblast cells are critical to spiral artery remodeling in hemochorial placentation. Insufficient trophoblast cell invasion and vascular remodeling can lead to pregnancy disorders including preeclampsia, preterm birth, and intrauterine gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed4bde041549017c882d1cd24eff3d2
https://doi.org/10.1073/pnas.2016517118
https://doi.org/10.1073/pnas.2016517118
Publikováno v:
Biology of Reproduction. 99:196-211
Placentation is a reproductive adaptation that permits fetal growth and development within the protected confines of the female reproductive tract. Through this important role, the placenta also determines postnatal health and susceptibility to disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307fc82c3116e2145dc0f84c386ed1c0
https://doi.org/10.1093/biolre/ioy049
https://doi.org/10.1093/biolre/ioy049
Publikováno v:
Placenta. 112:e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f86133a3db79f1b85ff7c7052ab05c89
https://doi.org/10.1016/j.placenta.2021.07.018
https://doi.org/10.1016/j.placenta.2021.07.018
Publikováno v:
Journal of Cellular Physiology. 232:1885-1892
Diabetes mellitus (DM) during pregnancy has long-lasting implications for the fetus, including cardiovascular morbidity. Previously, we showed that endothelial colony forming cells (ECFCs) from DM human pregnancies have decreased vasculogenic potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4197f1a0c2e69776113bd922f98478f5
https://doi.org/10.1002/jcp.25734
https://doi.org/10.1002/jcp.25734