Výsledky vyhledávání

Efficacy comparison of 3CL protease inhibitors ensitrelvir and nirmatrelvir against SARS-CoV-2 in vitro and in vivo

Autor: Takayuki Kuroda, Haruaki Nobori, Keita Fukao, Kaoru Baba, Kazumi Matsumoto, Shinpei Yoshida, Yukari Tanaka, Ryosuke Watari, Ryoko Oka, Yasuyuki Kasai, Kae Inoue, Sho Kawashima, Alice Shimba, Yoko Hayasaki-Kajiwara, Miki Tanimura, Qianhui Zhang, Yuki Tachibana, Teruhisa Kato, Takao Shishido

Publikováno v: Journal of Antimicrobial Chemotherapy. 78:946-952

Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become established in the human population, making the need to develop safe and effective treatments critical. We have developed the small-molecule antiviral ensitrelvir, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46e4838ce57f495c69db0e7a93c38576
https://doi.org/10.1093/jac/dkad027

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Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil

Autor: Miyako Okane, Steffen Wildum, Keiko Baba, Shinya Omoto, Akira Naito, Takao Shishido, Kae Inoue, Satoshi Hata, Takashi Hashimoto

Publikováno v: Influenza and Other Respiratory Viruses

Background Baloxavir marboxil (BXM) is an approved drug that selectively targets cap‐dependent endonuclease on PA subunit in the RNA polymerase complex of influenza A and B viruses. Amino acid substitutions at position 38 in the PA subunit were ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6258c0569b1328f9a007782e0760ae
https://doi.org/10.1111/irv.12821

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On the dual of Rauzy induction

Autor: Kae Inoue, Hitoshi Nakada

Publikováno v: Ergodic Theory and Dynamical Systems. 37:1492-1536

We investigate a certain dual relationship between piecewise rotations of a circle and interval exchange maps. In 2005, Cruz and da Rocha [A generalization of the Gauss map and some classical theorems on continued fractions. Nonlinearity18 (2005), 50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::599b6714d87cb17740360465c3cfb562
https://doi.org/10.1017/etds.2015.89

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A Piecewise Rotation of the Circle, IPR Maps and Their Connection with Translation Surfaces

Autor: Hitoshi Nakada, Kae Inoue

Publikováno v: Lecture Notes in Mathematics ISBN: 9783319749075

For given positive integers d j , \(1 \leqslant j \leqslant \forall s\), \(\sum _{j=1}^{s} d_{j}\) even, we construct a piecewise rotation map of the circle with \(\sum _{j=1}^{s} d_{j} \, + \, s\) discontinuous points such that its critical iterates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a13b0fd622ccaddd7dd383e3c8de2b5
https://doi.org/10.1007/978-3-319-74908-2_19

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On the Existence of a Darling-Kac Set for the Renormalized Rauzy Map

Autor: Hitoshi Nakada, Kae Inoue

Publikováno v: Tokyo J. of Math. 34, no. 2 (2011), 289-302

It is well-known that the renormalized Rauzy map is conservative and ergodic. In this paper, we show that a Darling-Kac set exists for the renormalized Rauzy map. This implies the pointwise dual ergodicity of this map.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04b9d7ea57db632803737fca19052d3
https://doi.org/10.3836/tjm/1327931385

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