Proteolytic maturation of α 2 δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

Autor: Kadurin, I, Ferron, L, Rothwell, SW, Meyer, JO, Douglas, LR, Bauer, CS, Lana, B, Margas, W, Alexopoulos, O, Nieto-Rostro, M, Pratt, WS, Dolphin, AC

The auxiliary α2δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptides α2 and δ. We now show, using α2δ constructs containing artifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6ce7c59c573583b3a086e4c506e85d2b

The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways

Autor: Alvarez-Laviada, A, Kadurin, I, Senatore, A, Chiesa, R, Dolphin, AC

It has been shown recently that PrP (prion protein) and the calcium channel auxiliary α2δ subunits interact in neurons and expression systems [Senatore, Colleoni, Verderio, Restelli, Morini, Condliffe, Bertani, Mantovani, Canovi, Micotti, Forloni,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::ec0c1822c60225ad8d6188c91b99a2bd
http://hdl.handle.net/10044/1/41708

Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium

Autor: Chen X., Paukert M., Kadurin I., Pusch M., Grunder S.

Publikováno v: Neuropharmacology 50 (2006): 964–974.
info:cnr-pdr/source/autori:Chen X., Paukert M., Kadurin I., Pusch M., Grunder S./titolo:Strong modulation by RFamide neuropeptides of the ASIC1b%2F3 heteromer in competition with extracellular calcium./doi:/rivista:Neuropharmacology/anno:2006/pagina_da:964/pagina_a:974/intervallo_pagine:964–974/volume:50

Acid-sensing ion channels are excitatory receptors for extracellular H+. Since the extracellular H+ concentration can significantly increase during an inflammation, one of the proposed functions for ASICs is peripheral perception of pain. The ASIC1b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::da19b105665fa0f4a11bc6849fbc3851
https://publications.cnr.it/doc/9508

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