Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kadee J. Raser"'
Autor:
Desiree Watson, John L. Gilmore, Juan C. Jaen, Daniel Stafford, Nilam Amin, Rathna Nath, Ravi Nadimpalli, Kevin K.W. Wang, Bradley William Caprathe, Sheryl J. Hays, Kadee J. Raser, Walter Michael, Mark R. Emmerling
Publikováno v:
Journal of Medicinal Chemistry. 41:1060-1067
A series of 2-amino-4H-3,1-benzoxazin-4-ones have been synthesized and evaluated as inhibitors of the complement enzyme C1r. C1r is a serine protease at the beginning of the complement cascade, and complement activation by beta-amyloid may represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806e519321a1a2f2fc9825d26ce2597b
https://doi.org/10.1021/jm970394d
https://doi.org/10.1021/jm970394d
Publikováno v:
IUBMB Life. 43:197-205
Thapsigargin, a specific inhibitor of the endoplasmic reticular Ca(2+)-ATPase, has been used previously to mobilize calcium release from intracellular calcium stores. We now show that thapsigargin (1-10 microM) induces apoptosis in a neuroblastoma ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bd824609e3f705a182403f5fe88fd7
https://doi.org/10.1080/15216549700203971
https://doi.org/10.1080/15216549700203971
Autor:
Robert V. Talanian, Po-Wai Yuen, Daniel Stafford, Avigail Posner, Kevin K.W. Wang, Hamish Allen, Rathna Nath, Iradj Hajimohammadreza, Kadee J. Raser, Richard B. Gilbertsen
Publikováno v:
Biochemical Journal. 319:683-690
The cytoskeletal protein non-erythroid alpha-spectrin is well documented as an endogenous calpain substrate, especially under pathophysiological conditions. In cell necrosis (e.g. maitotoxin-treated neuroblastoma SH-SY5Y cells), alpha-spectrin breakd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e908c233c5fde806f94cc0a8aa53161
https://doi.org/10.1042/bj3190683
https://doi.org/10.1042/bj3190683
Autor:
Charles Taylor, Kadee J. Raser, Avigail Posner, John J. Cordon, Kevin K.W. Wang, Nancy C. Kupina, Gerald P. Schielke, Mark G. Vartanian
Publikováno v:
Developmental Brain Research. 95:169-175
This study was performed to investigate whether the anticonvulsant phenytoin has neuroprotective effect in a model of hypoxia-ischemia with neonatal rats. The left carotid artery of each rat was ligated, followed by 3 h of hypoxic exposure (8% O2) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a1d84614dfd418b600448726953bea
https://doi.org/10.1016/0165-3806(96)00073-9
https://doi.org/10.1016/0165-3806(96)00073-9
Publikováno v:
Archives of Biochemistry and Biophysics. 331:208-214
Maitotoxin (MTX) is a highly potent marine toxin that activates both voltage-sensitive and receptor-operated calcium channels in the plasma membrane. This results in calcium overload that rapidly leads to cell death. We now report that maitotoxin (0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4f9361c748bcc37b8c5e1e063fc700
https://doi.org/10.1006/abbi.1996.0300
https://doi.org/10.1006/abbi.1996.0300
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1292:9-14
Human μ-calpain is activated maximally by 100–200 μM Ca 2+ . Both the 80 kDa and 29 kDa subunits of μ-calpain have a EF-hand type calcium-binding domain. It is known that trivalent terbium ion (Tb 3+ ) mimics Ca 2+ in many biological systems. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43524283942d4ce93c6138c3f77fc02
https://doi.org/10.1016/0167-4838(95)00170-0
https://doi.org/10.1016/0167-4838(95)00170-0
Publikováno v:
Archives of biochemistry and biophysics. 319(1)
A zymographic assay for calpains in nondenaturing casein-containing polyacrylamide gels was developed. Calpain samples were run into the polyacrylamide gels by electrophoresis using a Tris-glycine buffer containing 1 mM EGTA to stabilize calpains. Up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31abc6bc2bf5441956d1efca43a80b50
https://pubmed.ncbi.nlm.nih.gov/7771786
https://pubmed.ncbi.nlm.nih.gov/7771786
Publikováno v:
Neurobiology of Aging. 17:S190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c34d98b2ff3cf4616690138ae9dbcb7f
https://doi.org/10.1016/s0197-4580(96)80769-x
https://doi.org/10.1016/s0197-4580(96)80769-x
Autor:
Kadee J. Raser, Ravi Nadimpalli, Daniel Stafford, Kevin K.W. Wang, Rathna Nath, Kim M. McGinnis
Publikováno v:
Scopus-Elsevier
Both ice-like protease and calpain have been shown to be involved in apoptosis in non-neuronal cells. Cultured rat cerebellar granule neurons undergo apoptosis when exposed to low potassium-containing medium. Calpain inhibitors 3-(4-iodophenyl)-2-mer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ff84866ec19fb226ee14cf4091f006
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030893206&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030893206&partnerID=MN8TOARS
Autor:
Ravi Nadimpalli, Kadee J. Raser, Iradj Hajimohammadreza, Kevin K.W. Wang, Michele Scott, Rathna Nath
Publikováno v:
Scopus-Elsevier
Calpain (calcium-activated neutral protease) has been implicated as playing a role of neuronal injury in cerebral ischemia and excitotoxicity. Here we report that, in addition to extreme excitotoxic conditions [N-methyl-D-aspartate (NMDA), alpha-amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b24bf120b6ba56dd87b3fd0aaacf00
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030756917&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030756917&partnerID=MN8TOARS