Výsledky vyhledávání - "Kade D. Roberts"

Akademický článek

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Polymyxins are often the last therapeutic option for multidrug-resistant (MDR) bacteria, but have suboptimal safety and efficacy. Here the authors report the discovery and development of a synthetic lipopeptide with an improved safety and efficacy ag

Externí odkaz: https://doaj.org/article/0e3e6c3ab9774848b67a0f077533e996

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Akademický článek

An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates

Autor: Nitin A. Patil, Varsha J. Thombare, Rong Li, Xiaoji He, Jing Lu, Heidi H. Yu, Hasini Wickremasinghe, Kavya Pamulapati, Mohammad A. K. Azad, Tony Velkov, Kade D. Roberts, Jian Li

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

Peptide-Peptide Nucleic Acid (PNA) conjugates targeting essential bacterial genes have shown significant potential in developing novel antisense antimicrobials. The majority of efforts in this area are focused on identifying different PNA targets and

Externí odkaz: https://doaj.org/article/987c2d2a9dba4390adb3cc922eb2aceb

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Akademický článek

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

Autor: Mengyao Li, Mohammad A. K. Azad, Philip E. Thompson, Kade D. Roberts, Tony Velkov, Yan Zhu, Jian Li

Publikováno v: Antibiotics, Vol 12, Iss 2, p 415 (2023)

Polymyxins are last-line antibiotics for the treatment of Gram-negative ‘superbugs’. However, nephrotoxicity can occur in up to 60% of patients administered intravenous polymyxins. The mechanisms underpinning nephrotoxicity remain unclear. To und

Externí odkaz: https://doaj.org/article/5af3d28be2d1456e8d13a625f2595133

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Akademický článek

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

Autor: Jinxin Zhao, Soon-Ee Cheah, Kade D. Roberts, Roger L. Nation, Philip E. Thompson, Tony Velkov, Zongjun Du, Matthew D. Johnson, Jian Li

Publikováno v: mSphere, Vol 1, Iss 4 (2016)

ABSTRACT Polymyxin B and colistin are exclusively active against Gram-negative pathogens and have been used in the clinic as a last-line therapy. In this study, we investigated the antimicrobial activity of a novel polymyxin, FADDI-019, against Staph

Externí odkaz: https://doaj.org/article/bd826626e4e648538e291caaefb4a34a

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Akademický článek

Design and Evaluation of Novel Polymyxin Fluorescent Probes

Autor: Bo Yun, Kade D. Roberts, Philip E. Thompson, Roger L. Nation, Tony Velkov, Jian Li

Publikováno v: Sensors, Vol 17, Iss 11, p 2598 (2017)

Polymyxins (polymyxin B and colistin) are cyclic lipopeptide antibiotics that serve as a last-line defence against Gram-negative “superbugs”. In the present study, two novel fluorescent polymyxin probes were designed through regio-selective modif

Externí odkaz: https://doaj.org/article/560ff2347f454e4a96cc9936a3078e57

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A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

Autor: Kai Yang, Hasini Wickremasinghe, Lushan Wang, Xukai Jiang, Nitin A. Patil, Bin Gong, Lin Wan, Wendong Ma, Tony Velkov, Mengyao Li, Bing Yuan, Philip E. Thompson, Falk Schreiber, Jinxin Zhao, Xinru Zhang, Jian Li, Mohammad Abul Kalam Azad, Kade D. Roberts, Heidi Yu

Publikováno v: Chemical Science

Multidrug-resistant Gram-negative bacteria represent a major medical challenge worldwide. New antibiotics are desperately required with ‘old’ polymyxins often being the only available therapeutic option. Here, we systematically investigated the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f64aaa582cbacf04db90f00623cf795
https://doi.org/10.1039/d1sc03460j

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Simulations of octapeptin–outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency

Autor: Falk Schreiber, James D. Swarbrick, Bing Yuan, Nitin A. Patil, Xukai Jiang, Jian Li, Lushan Wang, Lin Wan, Kade D. Roberts, Bin Gong, Kai Yang, Tony Velkov

Publikováno v: J Biol Chem

The octapeptins are lipopeptide antibiotics that are structurally similar to polymyxins yet retain activity against polymyxin-resistant Gram-negative pathogens, suggesting they might be used to treat recalcitrant infections. However, the basis of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49275b879df34bcfd177f51edca4c47a
https://doi.org/10.1074/jbc.ra120.014856

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