An atlas of epithelial cell states and plasticity in lung adenocarcinoma.

Autor: Han G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sinjab A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rahal Z; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lynch AM; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA., Treekitkarnmongkol W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu Y; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA., Serrano AG; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liang K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khan K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lu W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hernandez SD; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cao X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dai E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pei G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hu J; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Abaya C; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gomez-Bolanos LI; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Peng F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA., Parra ER; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cascone T; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sepesi B; Department of Cardiovascular and Thoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Moghaddam SJ; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Negrao MV; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heymach JV; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dubinett SM; Department of Medicine, The University of California Los Angeles, Los Angeles, CA, USA., Stevenson CS; Lung Cancer Initiative at Johnson & Johnson, Boston, MA, USA., Spira AE; Lung Cancer Initiative at Johnson & Johnson, Boston, MA, USA.; Section of Computational Biomedicine, School of Medicine, Boston University, Boston, MA, USA., Fujimoto J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Solis LM; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen J; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. JChen16@mdanderson.org.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA. JChen16@mdanderson.org., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. lwang22@mdanderson.org.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA. lwang22@mdanderson.org., Kadara H; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. hkadara@mdanderson.org.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA. hkadara@mdanderson.org.

Publikováno v: Nature [Nature] 2024 Mar; Vol. 627 (8004), pp. 656-663. Date of Electronic Publication: 2024 Feb 28.

Inflammation mediated by gut microbiome alterations promotes lung cancer development and an immunosuppressed tumor microenvironment.

Autor: Rahal Z; The University of Texas MD Anderson Cancer Center, Houston, Texas, United States., Liu Y; The University of Texas MD Anderson Cancer Center, United States., Peng F; University of California, Irvine, Irvine, CA, United States., Yang S; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Jamal MA; The University of Texas MD Anderson Cancer Center, United States., Sharma M; The University of Texas MD Anderson Cancer Center, United States., Moreno H; Baylor College of Medicine, United States., Damania AV; The University of Texas MD Anderson Cancer Center, United States., Wong MC; The University of Texas MD Anderson Cancer Center, United States., Ross MC; Baylor College of Medicine, United States., Sinjab A; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Zhou T; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Chen M; Dana-Farber Cancer Institute, United States., Tarifa Reischle I; The University of Texas MD Anderson Cancer Center, United States., Feng J; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Chukwuocha C; The University of Texas MD Anderson Cancer Center, United States., Tang E; University of Illinois Urbana-Champaign, United States., Abaya C; Trinity University, United States., Lim JK; Johns Hopkins University, United States., Leung CH; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Lin HY; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Deboever N; The University of Texas Health Science Center at Houston, United States., Lee JJ; The University of Texas MD Anderson Cancer Center, Houston, Texas, United States., Sepesi B; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Gibbons DL; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Wargo JA; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Fujimoto J; Hiroshima University Hospital, Hiroshima, Hiroshima, Japan., Wang L; The University of Texas MD Anderson Cancer Center, Houston, Texas, United States., Petrosino JF; Baylor College of Medicine, Houston, TX, United States., Ajami NJ; The University of Texas MD Anderson Cancer Center, Houston, United States., Jenq RR; City Of Hope National Medical Center, Duarte, CA, United States., Moghaddam SJ; The University of Texas MD Anderson Cancer Center, Houston, Texas, United States., Cascone T; The University of Texas MD Anderson Cancer Center, Houston, United States., Hoffman K; Baylor College of Medicine, United States., Kadara H; The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2024 Sep 13. Date of Electronic Publication: 2024 Sep 13.

Suppressed immune microenvironment and repertoire in brain metastases from patients with resected non-small-cell lung cancer

Autor: Kudo, Y., Haymaker, C., Zhang, J., Reuben, A., Duose, D.Y., Fujimoto, J., Roy-Chowdhuri, S., Solis Soto, L.M., Dejima, H., Parra, E.R., Mino, B., Abraham, R., Ikeda, N., Vaporcyan, A., Gibbons, D., Lang, F.F., Luthra, R., Lee, J.J., Moran, C., Huse, J.T., Kadara, H., Wistuba, I.I. ^*

Publikováno v: In Annals of Oncology September 2019 30(9):1521-1530

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up

Autor: Kadara, H, Choi, M, Zhang, J., Parra, E.R., Rodriguez-Canales, J., Gaffney, S.G., Zhao, Z., Behrens, C., Fujimoto, J., Chow, C., Yoo, Y., Kalhor, N., Moran, C., Rimm, D., Swisher, S., Gibbons, D.L., Heymach, J., Kaftan, E., Townsend, J.P., Lynch, T.J., Schlessinger, J., Lee, J., Lifton, R.P., Wistuba, I.I. ^*, Herbst, R.S. ^*

Publikováno v: In Annals of Oncology January 2017 28(1):75-82

The evolution of lung adenocarcinoma precursors is associated with chromosomal instability and transition from innate to adaptive immune response/evasion.

Autor: Hu X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Zhu B; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Vokes N; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Fujimoto J; Hiroshima University Hospital, Hiroshima 7348551, Japan., Rojas Alvarez FR; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Heeke S; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Moreira AL; Department of Pathology, New York University Langone Medical Center, New York, 10012, USA., Solis LM; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Haymaker C; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Velcheti V; Department of Medical oncology, New York University, New York, 10012, USA., Sterman DH; Department of Pulmonary, New York University, New York, 10012, USA., Pass HI; Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, 10016, USA., Cheng C; Department of Medicine, Epidemiology and Population Science, Baylor College of Medicine. Houston, TX, 77030, USA., Lee JJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Zhang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wei Z; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wu J; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Le X; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Ostrin E; Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Toumazis I; Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Gibbons D; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Su D; Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China.; Department of Pathology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, 310022, China., Fukuoka J; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 8528523, Japan., Antonoff MB; Department of Thoracic & Cardiovasc Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Gerber DE; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, 75390, USA., Li C; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Kadara H; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Davis M; Moores Cancer Center, UC San Diego School of Medicine, San Diego, CA, 92037, USA., Heymach JV; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Hannash S; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wistuba I; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Dubinett S; Departments of Medicine and Pathology, University of California Los Angeles and Greater Los Angeles Healthcare System, Los Angeles, CA, 90095, USA., Alexandrov L; Moores Cancer Center, UC San Diego School of Medicine, San Diego, CA, 92037, USA., Lippman S; Moores Cancer Center, UC San Diego School of Medicine, San Diego, CA, 92037, USA., Spira A; Pathology & Laboratory Medicine, and Bioinformatics, Boston University, Boston, MA, 02215, USA., Futreal AP; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Reuben A; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Zhang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Lead contact.

Publikováno v: Research square [Res Sq] 2024 May 15. Date of Electronic Publication: 2024 May 15.