Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

Autor: Patel, RS, Schmidt, AF, Tragante, V, McCubrey, RO, Holmes, MV, Howe, LJ, Direk, K, Åkerblom, A, Leander, K, Virani, SS, Kaminski, KA, Muehlschlegel, JD, Dubé, M-P, Allayee, H, Almgren, P, Alver, M, Baranova, EV, Behlouli, H, Boeckx, B, Braund, PS, Breitling, LP, Delgado, G, Duarte, NE, Dufresne, L, Eriksson, N, Foco, L, Gijsberts, CM, Gong, Y, Hartiala, J, Heydarpour, M, Hubacek, JA, Kleber, M, Kofink, D, Kuukasjärvi, P, Lee, V-V, Leiherer, A, Lenzini, PA, Levin, D, Lyytikäinen, L-P, Martinelli, N, Mons, U, Nelson, CP, Nikus, K, Pilbrow, AP, Ploski, R, Sun, YV, Tanck, MWT, Tang, WHW, Trompet, S, Van Der Laan, SW, Van Setten, J, Vilmundarson, RO, Anselmi, C, Vlachopoulou, E, Boerwinkle, E, Briguori, C, Carlquist, JF, Carruthers, KF, Casu, G, Deanfield, J, Deloukas, P, Dudbridge, F, Fitzpatrick, N, Gigante, B, James, S, Lokki, M-L, Lotufo, PA, Marziliano, N, Mordi, IR, Muhlestein, JB, Newton-Cheh, C, Pitha, J, Saely, CH, Samman-Tahhan, A, Sandesara, PB, Teren, A, Timmis, A, Van De Werf, F, Wauters, E, Wilde, AAM, Ford, I, Stott, DJ, Algra, A, Andreassi, MG, Ardissino, D, Arsenault, BJ, Ballantyne, CM, Bergmeijer, TO, Bezzina, CR, Body, SC, Bogaty, P, De Borst, GJ, Brenner, H, Burkhardt, R, Carpeggiani, C, Condorelli, G, Cooper-Dehoff, RM, Cresci, S, De Faire, U, Doughty, RN, Drexel, H, Engert, JC, Fox, KAA, Girelli, D, Hagström, E, Hazen, SL, Held, C, Hemingway, H, Hoefer, IE, Hovingh, GK, Johnson, JA, De Jong, PA, Jukema, JW, Kaczor, MP, Kähönen, M, Kettner, J, Kiliszek, M, Klungel, OH, Lagerqvist, B, Lambrechts, D, Laurikka, JO, Lehtimäki, T, Lindholm, D, Mahmoodi, BK, Der Zee, AH, McPherson, R, Melander, O, Metspalu, A, Pepinski, W, Olivieri, O, Opolski, G, Palmer, CN, Pasterkamp, G, Pepine, CJ, Pereira, AC, Pilote, L, Quyyumi, AA, Richards, AM, Sanak, M, Scholz, M, Siegbahn, A, Sinisalo, J, Smith, JG, Spertus, JA, Stewart, AFR, Szczeklik, W, Szpakowicz, A, Berg, JM, Thanassoulis, G, Thiery, J, Van Der Graaf, Y, Visseren, FLJ, Waltenberger, J, Van Der Harst, P, Tardif, J-C, Sattar, N, Lang, CC, Paré, G, Brophy, JM, Anderson, JL, März, W, Wallentin, L, Cameron, VA, Horne, BD, Samani, NJ, Hingorani, AD, Asselbergs, FW

Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk.A va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86d67053a6d54128f7e80f8f66460c21
http://hdl.handle.net/11562/1028981

Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.

Autor: Mahmoodi BK; St. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (B.K.M., T.O.B., J.M.t.B.).; Division of Hemostasis and Thrombosis, Department of Hematology, UMC Groningen, University of Groningen, The Netherlands (B.K.M.)., Tragante V; Department of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (M.E.K., G.E.D., W.M.)., Holmes MV; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health and Medical Research Council Population Health Research Unit, University of Oxford, United Kingdom (M.V.H.).; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, United Kingdom (M.V.H.)., Schmidt AF; Department of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands.; Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.)., McCubrey RO; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.McC.)., Howe LJ; Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.)., Direk K; Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.)., Allayee H; Departments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of University of Southern California, Los Angeles., Baranova EV; Division of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), UMC Utrecht, Utrecht University, the Netherlands., Braund PS; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.).; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.)., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (M.E.K., G.E.D., W.M.)., Eriksson N; Uppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.)., Gijsberts CM; Laboratory of Experimental Cardiology (C.M.G.), UMC Utrecht, Utrecht University, the Netherlands., Gong Y; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D.H., J.A.J.), University of Florida, Gainesville., Hartiala J; Departments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of University of Southern California, Los Angeles.; Institute for Genetic Medicine (J.H.), Keck School of Medicine of University of Southern California, Los Angeles., Heydarpour M; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (M.H., J.D.M.).; Harvard Medical School, Harvard University, Boston, MA (M.H., J.D.M.)., Pasterkamp G; Department of Clinical Chemistry (G.Pasterkamp), UMC Utrecht, Utrecht University, the Netherlands., Kotti S; Assistance Publique-Hôpitaux de Paris (APHP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), France (S.K.)., Kuukasjärvi P; Departments of Cardio-Thoracic Surgery (P.K., J.O.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland., Lenzini PA; Department of Genetics, Statistical Genomics Division (P.A.L., S.C.), Washington University School of Medicine, Saint Louis, MO., Levin D; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D.L., I.R.M., C.C.L.)., Lyytikäinen LP; Clinical Chemistry (L.-P.L., T.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.)., Muehlschlegel JD; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (M.H., J.D.M.).; Harvard Medical School, Harvard University, Boston, MA (M.H., J.D.M.)., Nelson CP; Laboratory of Experimental Cardiology (C.M.G.), UMC Utrecht, Utrecht University, the Netherlands.; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.)., Nikus K; Cardiology (K.N.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.; Department of Cardiology (K.N.), Heart Center, Tampere University Hospital, Finland., Pilbrow AP; The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.)., Wilson Tang WH; Department of Cardiovascular and Metabolic Sciences, Lerner Research institute (W.H.W.T., S.L.H.), Cleveland Clinic, OH.; Department of Cardiovascular Medicine, Heart and Vascular Institute (W.H.W.T.), Cleveland Clinic, OH., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics (S.W.v.d.L.), UMC Utrecht, Utrecht University, the Netherlands., van Setten J; Department of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands., Vilmundarson RO; Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ontario, Canada (R.O.V., A.F.R.S.)., Deanfield J; Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.)., Deloukas P; William Harvey Research Institute, Barts and the London Medical School, and the Centre for Genomic Health, Queen Mary University of London, United Kingdom (P.D.)., Dudbridge F; Department of Health Sciences, University of Leicester, United Kingdom (F.D.)., James S; Uppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).; Department of Medical Sciences, Cardiology, Uppsala University, Sweden (S.J., E.H., C.H., A.Å., L.W.)., Mordi IR; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D.L., I.R.M., C.C.L.)., Teren A; Heart Center Leipzig, Germany (A.T.).; LIFE Research Center for Civilization Diseases (A.T., R.B., M.Scholz, J.T.), University of Leipzig, Germany., Bergmeijer TO; St. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (B.K.M., T.O.B., J.M.t.B.)., Body SC; Department of Anesthesiology, Boston University School of Medicine, MA (S.C.B.)., Bots M; Julius Center for Health Sciences and Primary Care (M.B., D.E.G.), UMC Utrecht, Utrecht University, the Netherlands.; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany (R.B.)., Burkhardt R; LIFE Research Center for Civilization Diseases (A.T., R.B., M.Scholz, J.T.), University of Leipzig, Germany., Cooper-DeHoff RM; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D.H., J.A.J.), University of Florida, Gainesville.; College of Medicine, Division of Cardiovascular Medicine (R.M.C.-D.H., J.A.J., C.J.P.), University of Florida, Gainesville., Cresci S; Department of Genetics, Statistical Genomics Division (P.A.L., S.C.), Washington University School of Medicine, Saint Louis, MO.; Department of Medicine, Cardiovascular Division (S.C.), Washington University School of Medicine, Saint Louis, MO., Danchin N; Assistance Publique-Hôpitaux de Paris (APHP), Department of Cardiology, Hôpital Européen Georges Pompidou; FACT (french Alliance for cardiovascular trials); and Université Paris Descartes, France (N.D.)., Doughty RN; Heart Health Research Group, University of Auckland, New Zealand (R.N.D.)., Grobbee DE; Julius Center for Health Sciences and Primary Care (M.B., D.E.G.), UMC Utrecht, Utrecht University, the Netherlands., Hagström E; Department of Medical Sciences, Cardiology, Uppsala University, Sweden (S.J., E.H., C.H., A.Å., L.W.).; Department of Cardiology, Uppsala University, and Uppsala Clinical Research Center, Sweden (E.H.)., Hazen SL; Department of Cardiovascular and Metabolic Sciences, Lerner Research institute (W.H.W.T., S.L.H.), Cleveland Clinic, OH.; Center for Microbiome and Human Health (S.L.H.), Cleveland Clinic, OH., Held C; Uppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).; Department of Medical Sciences, Cardiology, Uppsala University, Sweden (S.J., E.H., C.H., A.Å., L.W.)., Hoefer IE; Department of Clinical Chemistry and Hematology (I.E.H.), UMC Utrecht, Utrecht University, the Netherlands., Hovingh GK; Department of Vascular Medicine (G.K.H.), Academic Medical Center, University of Amsterdam, The Netherlands., Johnson JA; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D.H., J.A.J.), University of Florida, Gainesville.; College of Medicine, Division of Cardiovascular Medicine (R.M.C.-D.H., J.A.J., C.J.P.), University of Florida, Gainesville., Kaczor MP; Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.Sanak, W.S.)., Kähönen M; Clinical Physiology (M.K.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.; Department of Clinical Physiology, Tampere University Hospital, Finland (M.K.)., Klungel OH; Division of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), UMC Utrecht, Utrecht University, the Netherlands., Laurikka JO; Departments of Cardio-Thoracic Surgery (P.K., J.O.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.; Department of Cardio-Thoracic Surgery (J.O.L.), Heart Center, Tampere University Hospital, Finland., Lehtimäki T; Clinical Chemistry (L.-P.L., T.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.)., Maitland-van der Zee AH; Division of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), UMC Utrecht, Utrecht University, the Netherlands.; Department of Respiratory Medicine (A.H.M.-v.d.Z.), Academic Medical Center, University of Amsterdam, The Netherlands., McPherson R; Departments of Medicine and Biochemistry, Microbiology, and Immunology, University of Ottawa, Ontario, Canada (R.McP. R.O.V., A.F.R.S.)., Palmer CN; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.N.P.)., Kraaijeveld AO; Department of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands., Pepine CJ; College of Medicine, Division of Cardiovascular Medicine (R.M.C.-D.H., J.A.J., C.J.P.), University of Florida, Gainesville., Sanak M; Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.Sanak, W.S.)., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (N.S.)., Scholz M; LIFE Research Center for Civilization Diseases (A.T., R.B., M.Scholz, J.T.), University of Leipzig, Germany.; Institute for Medical Informatics, Statistics, and Epidemiology (M.Scholz), University of Leipzig, Germany., Simon T; Assistance Publique-Hôpitaux de Paris (APHP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), FACT (French Alliance for Cardiovascular trials); Sorbonne Université, Paris-06, France (T.S.).; Paris-Sorbonne University, UPMC-Site St Antoine, France (T.S.)., Spertus JA; University of Missouri-Kansas City (J.A.S.).; Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.)., Stewart AFR; Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ontario, Canada (R.O.V., A.F.R.S.).; Departments of Medicine and Biochemistry, Microbiology, and Immunology, University of Ottawa, Ontario, Canada (R.McP. R.O.V., A.F.R.S.)., Szczeklik W; Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.Sanak, W.S.)., Thiery J; LIFE Research Center for Civilization Diseases (A.T., R.B., M.Scholz, J.T.), University of Leipzig, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany (J.T.)., Visseren FLJ; Department of Vascular Medicine (F.L.J.V.), UMC Utrecht, Utrecht University, the Netherlands., Waltenberger J; Department of Cardiovascular Medicine, University of Münster, Germany (J.W.)., Richards AM; The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).; Cardiovascular Research Institute, National University of Singapore (A.M.R.)., Lang CC; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D.L., I.R.M., C.C.L.)., Cameron VA; The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.)., Åkerblom A; Uppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).; Department of Medical Sciences, Cardiology, Uppsala University, Sweden (S.J., E.H., C.H., A.Å., L.W.)., Pare G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada (G.Pare).; Population Health Research Institute, Hamilton, Ontario, Canada (G.Pare)., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (M.E.K., G.E.D., W.M.).; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany (W.M.).; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria (W.M.)., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.).; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.)., Hingorani AD; Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.)., Ten Berg JM; St. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (B.K.M., T.O.B., J.M.t.B.)., Wallentin L; Uppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.)., Asselbergs FW; Department of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands.; Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).; Health Data Research UK and Institute of Health Informatics, University College London, United Kingdom (F.W.A.)., Patel RS; Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).; Bart's Heart Centre, St Bartholomew's Hospital, London, United Kingdom (R.S.P.).

Publikováno v: Circulation [Circulation] 2020 Aug 11; Vol. 142 (6), pp. 546-555. Date of Electronic Publication: 2020 Jul 13.

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Autor: Patel RS; Institute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.; Bart's Heart Centre, St Bartholomew's Hospital, London (R.S.P., J.D., A. Timmis)., Tragante V; Division of Heart and Lungs, Department of Cardiology (V.T., A.F.S.,D.K.,F.W.A.), UMC Utrecht, the Netherlands., Schmidt AF; Institute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.; Division of Heart and Lungs, Department of Cardiology (V.T., A.F.S.,D.K.,F.W.A.), UMC Utrecht, the Netherlands., McCubrey RO; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H)., Holmes MV; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Medical Research Council Population Health Research Unit, University of Oxford, United Kingdom (M.V.H).; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, United Kingdom (M.V.H.)., Howe LJ; Institute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom., Direk K; Institute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom., Åkerblom A; Uppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).; Division of Cardiology, Department of Medical Sciences (A. Åkerblom, C.H., D. Lindholm, S.J., B.L., L.W.), Uppsala University, Sweden., Leander K; Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (K.L., B.G., U.d.F.)., Virani SS; Section of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (S.S.V.).; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V., C.M.B.)., Kaminski KA; Department of Population Medicine and Civilization Disease Prevention (K.A.K.), Medical University of Bialystok, Poland.; Department of Cardiology (K.A.K., A. Szpakowicz), Medical University of Bialystok, Poland., Muehlschlegel JD; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (J.D.M., M.H.).; Harvard Medical School, Boston, MA (J.D.M., M.H., S.C.B)., Allayee H; Departments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of USC, Los Angeles, CA., Almgren P; Department of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.)., Alver M; Estonian Genome Centre, Department of Biotechnology, Institute of Genomics, Institute of Molecular and Cell Biology, University of Tartu, Estonia (M.A., A.M.)., Baranova EV; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, the Netherlands (E.V.B., O.H.K., A.H.M.-v.d.Z.)., Behloui H; Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.)., Boeckx B; Laboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts), Katholieke Universiteit Leuven, Belgium.; Laboratory for Translational Genetics, VIB Center for Cancer Biology, Belgium (B.B., D. Lambrechts)., Braund PS; Department of Cardiovascular Sciences, BHF Cardiovascular Research Centre, University of Leicester, United Kingdom (P.S.B., C.P.N., N.J.S.).; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.)., Breitling LP; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M.)., Delgado G; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (G.D., M. Kleber, W.M.)., Duarte NE; Heart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.)., Dubé MP; Montreal Heart Institute, OC, Canada (M.-P.D., J.-C.T.).; Faculty of Medicine, Université de Montréal, QC, Canada (M.-P.D., J.-C.T.)., Dufresne L; Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).; Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, QC, Canada (L.D., J.C.E., G.T.)., Eriksson N; Uppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.)., Foco L; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (L.F.)., Scholz M; Institute for Medical Informatics, Statistics, and Epidemiology (M.S.), University of Leipzig, Germany.; LIFE Research Centre for Civilization Diseases (M.S., A. Teren, R.B., J.T.), University of Leipzig, Germany., Gijsberts CM; Laboratory of Experimental Cardiology (C.M.G.), UMC Utrecht, the Netherlands., Glinge C; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet (C.G., T.E., R.J.).; Amsterdam UMC, University of Amsterdam, Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, AMC Heart Center, the Netherlands (C.G., A.A.M.W., C.R.B.)., Gong Y; Department of Pharmacotherapy and Translational Research, Centre for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.), University of Florida, Gainesville., Hartiala J; Institute for Genetic Medicine (J.H.), Keck School of Medicine of USC, Los Angeles, CA., Heydarpour M; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (J.D.M., M.H.).; Harvard Medical School, Boston, MA (J.D.M., M.H., S.C.B)., Hubacek JA; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (J.A.H., J.P.)., Kleber M; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (G.D., M. Kleber, W.M.)., Kofink D; Division of Heart and Lungs, Department of Cardiology (V.T., A.F.S.,D.K.,F.W.A.), UMC Utrecht, the Netherlands., Kotti S; Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), France (S.K.)., Kuukasjärvi P; Department of Cardio-Thoracic Surgery (P.K.), University of Tampere, Finland., Lee VV; Department of Biostatistics and Epidemiology, Texas Heart Institute, Houston (V.-V.L.)., Leiherer A; Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A. Leiherer, C.H.S., H.D.).; Private University of the Principality of Liechtenstein, Triesen (A. Leiherer, C.H.S., H.D.).; Medical Central Laboratories, Feldkirch, Austria (A. Leiherer)., Lenzini PA; Statistical Genomics Division, Department of Genetics (P.A. Lenzini, S.C.), Washington University School of Medicine, Saint Louis, MO., Levin D; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.)., Lyytikäinen LP; Department of Clinical Chemistry (L.-P.L., T.L.), University of Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.)., Martinelli N; Department of Medicine, University of Verona, Italy (N.M., D.G., O.O.)., Mons U; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M.)., Nelson CP; Department of Cardiovascular Sciences, BHF Cardiovascular Research Centre, University of Leicester, United Kingdom (P.S.B., C.P.N., N.J.S.).; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.)., Nikus K; Department of Cardiology (K.N.), University of Tampere, Finland.; Department of Cardiology, Heart Center (K.N.), Tampere University Hospital, Finland., Pilbrow AP; The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.)., Ploski R; Department of Medical Genetics (R. Ploski), Medical University of Warsaw, Poland., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA (Y.V.S.).; Department of Biomedical Informatics (Y.V.S.), Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA., Tanck MWT; Amsterdam UMC, University of Amsterdam, Clinical Epidemiology and Biostatistics, The Netherlands (M.W.T.T.)., Tang WHW; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (W.H.W.T., S.L.H.).; Department of Cardiovascular Medicine, Heart and Vascular Institute, and Centre for Clinical Genomics, Cleveland Clinic, OH (W.H.W.T.)., Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicine (S.T.), Leiden University Medical Centre, the Netherlands.; Department of Cardiology (S.T., J.W.J.), Leiden University Medical Centre, the Netherlands., van der Laan SW; Division Laboratories, Pharmacy, and Biomedical Genetics, Laboratory of Clinical Chemistry and Hematology (S.W.v.d.L.), UMC Utrecht, Utrecht University, the Netherlands., Van Setten J; Division Heart and Lungs, Department of Cardiology, UMC Utrecht, University of Utrecht, the Netherlands (J.V.S.)., Vilmundarson RO; Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Canada (R.O.V., R.M., A.F.R.S.).; Department of Biochemistry, Microbiology and Immunology (R.O.V., A.F.R.S.), University of Ottawa, ON, Canada., Viviani Anselmi C; Department of Cardiovascular Medicine, Humanitas Clinical and Research Centre, Milan, Italy (C.V.A., G.C.)., Vlachopoulou E; Transplantation Laboratory (E.V., M.-L.L.), Helsinki University Hospital and University of Helsinki, Finland., Al Ali L; University Medical Centre, University of Groningen, the Netherlands (L.A.A., P.V.d.H.)., Boerwinkle E; University of Texas School of Public Health, Houston(E.B.)., Briguori C; Clinica Mediterranea, Naples, Italy (C.B.)., Carlquist JF; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).; Cardiology Division, Department of Internal Medicine (J.F.C., J.B.M., J.L.A.), University of Utah, Salt Lake City., Carruthers KF; QMRI, Cardiovascular Sciences, University of Edinburgh, United Kingdom (K.F.C.)., Casu G; Department of Cardiovascular Medicine, Humanitas Clinical and Research Centre, Milan, Italy (C.V.A., G.C.).; ATS Sardegna, ASSL Nuoro-Ospedale San Francesco, Nuoro, Italy (G.C.).; Department of Biomedical Sciences, Humanitas University, Milan, Italy (G.C.)., Deanfield J; Institute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom.; Bart's Heart Centre, St Bartholomew's Hospital, London (R.S.P., J.D., A. 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Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom., Fox K; National Heart and Lung Institute, Imperial College and Institute of Cardiovascular Medicine and Science, Royal Brompton Hospital, London, United Kingdom (K.F.)., Gigante B; Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (K.L., B.G., U.d.F.)., James S; Uppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).; Division of Cardiology, Department of Medical Sciences (A. Åkerblom, C.H., D. Lindholm, S.J., B.L., L.W.), Uppsala University, Sweden., Lokki ML; Transplantation Laboratory (E.V., M.-L.L.), Helsinki University Hospital and University of Helsinki, Finland., Lotufo PA; Centro de Pesquisa Clinica, Hospital Universitario, Universidade de Sao Paulo, São Paulo, Brazil (P.A. Lotufo, )., Marziliano N; ATS Sardegna, ASL 3 Nuoro, Nuoro, Italy (N. 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Algra), UMC Utrecht, Utrecht University, the Netherlands., Andreassi MG; CNR Institute of Clinical Physiology, Pisa (M.G.A, C.C)., Ardissino D; Cardiology Department, Parma University Hospital, Italy (D.A.)., Arsenault BJ; Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec, Canada (B.J.A.).; Department of Medicine, Faculty of Medicine, Université Laval, QC, Canada (B.J.A.)., Ballantyne CM; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V., C.M.B.)., Bergmeijer TO; St Antonius Hospital, Department Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.)., Bezzina CR; Amsterdam UMC, University of Amsterdam, Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, AMC Heart Center, the Netherlands (C.G., A.A.M.W., C.R.B.)., Body SC; Harvard Medical School, Boston, MA (J.D.M., M.H., S.C.B).; Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA (S.B.)., Boersma EH; Department of Cardiology, Erasmus MC, Thoraxcenter (E.H.B., J.J.B.).; Cardiovascular Research School, Erasmus Medical Center (COEUR), Rotterdam, the Netherlands(E.H.B.)., Bogaty P; Laval University, Institute universitaire de cardiologie et de pneumologie de Québec, Canada (P.B.)., Bots ML; Julius Center for Health Sciences and Primary Care (M.B., D.E.G., Y.v.d.G.), UMC Utrecht, Utrecht University, the Netherlands., Brenner H; Network Aging Research (NAR), University of Heidelberg (H.B.)., Brugts JJ; Department of Cardiology, Erasmus MC, Thoraxcenter (E.H.B., J.J.B.)., Burkhardt R; LIFE Research Centre for Civilization Diseases (M.S., A. Teren, R.B., J.T.), University of Leipzig, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany (R.B.)., Carpeggiani C; CNR Institute of Clinical Physiology, Pisa (M.G.A, C.C)., Condorelli G; Institute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom., Cooper-DeHoff RM; Department of Pharmacotherapy and Translational Research, Centre for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.), University of Florida, Gainesville.; Division of Cardiovascular Medicine, College of Medicine (R.M.C.-D., J.A.J., C.J.P.), University of Florida, Gainesville., Cresci S; Statistical Genomics Division, Department of Genetics (P.A. Lenzini, S.C.), Washington University School of Medicine, Saint Louis, MO.; Cardiovascular Division, Department of Medicine (S.C.), Washington University School of Medicine, Saint Louis, MO., Danchin N; Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Cardiology, Hôpital Européen Georges Pompidou & FACT (French Alliance For Cardiovascular Trials), Université Paris Descartes, France (N.D.).; Université Paris-Descartes, France (N.D.)., de Faire U; Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (K.L., B.G., U.d.F.)., Doughty RN; Heart Health Research Group, University of Auckland, New Zealand (R.N.D.)., Drexel H; Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A. Leiherer, C.H.S., H.D.).; Private University of the Principality of Liechtenstein, Triesen (A. Leiherer, C.H.S., H.D.).; Drexel University College of Medicine, Philadelphia PA (H.D.)., Engert JC; Research Institute of the McGill University Health Centre, Montreal, QC, Canada (J.C.E.).; Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, QC, Canada (L.D., J.C.E., G.T.).; Division of Cardiology, Department of Medicine, Royal Victoria Hospital, McGill Univ Health Centre, Montreal, QC, Canada (J.C.E., G.T.)., Fox KAA; The University of Edinburgh, United Kingdom (K.A.A.F)., Girelli D; Department of Medicine, University of Verona, Italy (N.M., D.G., O.O.)., Grobbee DE; Julius Center for Health Sciences and Primary Care (M.B., D.E.G., Y.v.d.G.), UMC Utrecht, Utrecht University, the Netherlands., Hagström E; Department of Cardiology, Uppsala Clinical Research Centre, Uppsala University, Sweden (E.H.)., Hazen SL; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, OH (W.H.W.T., S.L.H.).; Department of Cardiovascular Medicine, Centre for Microbiome and Human Health, Heart and Vascular Institute, Cleveland Clinic, OH (S.L.H.)., Held C; Uppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).; Division of Cardiology, Department of Medical Sciences (A. Åkerblom, C.H., D. Lindholm, S.J., B.L., L.W.), Uppsala University, Sweden., Hemingway H; Institute of Cardiovascular Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A), Faculty of Population Health Science, University College London, United Kingdom., Hoefer IE; Department of Clinical Chemistry and Hematology (I.E.H.), UMC Utrecht, the Netherlands., Hovingh GK; Department of Vascular Medicine, Academic Medical Centre, Amsterdam (G.K.H.)., Jabbari R; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet (C.G., T.E., R.J.)., Johnson JA; Department of Pharmacotherapy and Translational Research, Centre for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.), University of Florida, Gainesville.; Division of Cardiovascular Medicine, College of Medicine (R.M.C.-D., J.A.J., C.J.P.), University of Florida, Gainesville., Jukema JW; Department of Cardiology (S.T., J.W.J.), Leiden University Medical Centre, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden (J.W.J.).; Interuniversity Cardiology Institute of the Netherlands, Utrecht (J.W.J.)., Kaczor MP; Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.S., W.S)., Kähönen M; Department of Clinical Physiology (M. Kähönen), University of Tampere, Finland.; Department of Clinical Physiology (M. Kähönen), Tampere University Hospital, Finland., Kettner J; Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (J.K.)., Kiliszek M; Department of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland (M. Kiliszek)., Klungel OH; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, the Netherlands (E.V.B., O.H.K., A.H.M.-v.d.Z.)., Lagerqvist B; Uppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).; Division of Cardiology, Department of Medical Sciences (A. Åkerblom, C.H., D. Lindholm, S.J., B.L., L.W.), Uppsala University, Sweden., Lambrechts D; Laboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts), Katholieke Universiteit Leuven, Belgium., Laurikka JO; Department of Cardio-Thoracic Surgery, Finnish Cardiovascular Research Center, Faculty of Medicine & Life Sciences (J.O.L.), University of Tampere, Finland.; Department of Cardio-Thoracic Surgery, Heart Centre (J.O.L.), Tampere University Hospital, Finland., Lehtimäki T; Department of Clinical Chemistry (L.-P.L., T.L.), University of Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.)., Lindholm D; Uppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).; Division of Cardiology, Department of Medical Sciences (A. Åkerblom, C.H., D. Lindholm, S.J., B.L., L.W.), Uppsala University, Sweden., Mahmoodi BK; St Antonius Hospital, Department Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.)., Maitland-van der Zee AH; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, the Netherlands (E.V.B., O.H.K., A.H.M.-v.d.Z.).; Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam (A.H.M.-v.d.Z.)., McPherson R; Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Canada (R.O.V., R.M., A.F.R.S.).; Departments of Medicine and Biochemistry, Microbiology and Immunology(R.M.), University of Ottawa, ON, Canada., Melander O; Department of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.).; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden (O.M.)., Metspalu A; Estonian Genome Centre, Department of Biotechnology, Institute of Genomics, Institute of Molecular and Cell Biology, University of Tartu, Estonia (M.A., A.M.)., Niemcunowicz-Janica A; Department of Forensic Medicine; Medical University of Bialystok (A.N.-J.)., Olivieri O; Department of Medicine, University of Verona, Italy (N.M., D.G., O.O.)., Opolski G; first Chair and Department of Cardiology (G.O.), Medical University of Warsaw, Poland., Palmer CN; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee (C.N.P.)., Pasterkamp G; Department of Clinical Chemistry (G.P.), UMC Utrecht, the Netherlands., Pepine CJ; Division of Cardiovascular Medicine, College of Medicine (R.M.C.-D., J.A.J., C.J.P.), University of Florida, Gainesville., Pereira AC; Heart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.)., Pilote L; Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).; Department of Medicine, McGill University Health Centre, Montreal, QC, Canada (L.P., J.M.B.)., Quyyumi AA; Division of Cardiology, Department of Medicine (A.S.-T., P.B.S., A.A.Q.), Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA., Richards AM; The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).; Cardiovascular Research Institute, National University of Singapore (A.M.R.)., Sanak M; Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.S., W.S)., Siegbahn A; Uppsala Clinical Research Center, Sweden (A. Åkerblom, N.E., S.J., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.).; Division of Clinical Chemistry, Department of Medical Sciences (A. Siegbahn), Uppsala University, Sweden., Simon T; Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), FACT (French Alliance for Cardiovascular Trials), Sorbonne Université (T.S.).; Paris-Sorbonne University, UPMC-Site St Antoine, France (T.S.)., Sinisalo J; Heart and Lung Centre (J.S.), Helsinki University Hospital and University of Helsinki, Finland., Smith JG; Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital (J.G.S.).; Wallenberg Centre for Molecular Medicine, Lund University Diabetes Centre, Lund University, Sweden (J.G.S.).; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (J.G.S.)., Spertus JA; Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City (J.A.S.).; Saint Luke's Mid America Heart Insti Kansas City, MO (J.A.S.)., Stender S; Department of Clinical Biochemistry, Copenhagen University Hospital, Gentofte (S.S.)., Stewart AFR; Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Canada (R.O.V., R.M., A.F.R.S.).; Department of Biochemistry, Microbiology and Immunology (R.O.V., A.F.R.S.), University of Ottawa, ON, Canada., Szczeklik W; Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.S., W.S)., Szpakowicz A; Department of Cardiology (K.A.K., A. Szpakowicz), Medical University of Bialystok, Poland., Tardif JC; Montreal Heart Institute, OC, Canada (M.-P.D., J.-C.T.).; Faculty of Medicine, Université de Montréal, QC, Canada (M.-P.D., J.-C.T.)., Ten Berg JM; St Antonius Hospital, Department Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.)., Tfelt-Hansen J; Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet (J.T.-H.).; Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark (J.T.-Hansen)., Thanassoulis G; Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).; Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, QC, Canada (L.D., J.C.E., G.T.).; Division of Cardiology, Department of Medicine, Royal Victoria Hospital, McGill Univ Health Centre, Montreal, QC, Canada (J.C.E., G.T.)., Thiery J; LIFE Research Centre for Civilization Diseases (M.S., A. Teren, R.B., J.T.), University of Leipzig, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany (J.T.)., Torp-Pedersen C; Unit of Epidemiology and Biostatistics, Department of Health Science and Technology, Aalborg University Hospital, Denmark (C.T.-Pedersen)., van der Graaf Y; Julius Center for Health Sciences and Primary Care (M.B., D.E.G., Y.v.d.G.), UMC Utrecht, Utrecht University, the Netherlands., Visseren FLJ; Department of Vascular Medicine (F.L.J.V), UMC Utrecht, Utrecht University, the Netherlands., Waltenberger J; Department of Cardiovascular Medicine, University of Münster, Germany (J.W.)., Weeke PE; Department of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark (P.E.W.)., Van der Harst P; University Medical Centre, University of Groningen, the Netherlands (L.A.A., P.V.d.H.)., Lang CC; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.)., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (D.J.S., N.S.)., Cameron VA; The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.)., Anderson JL; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).; Cardiology Division, Department of Internal Medicine (J.F.C., J.B.M., J.L.A.), University of Utah, Salt Lake City., Brophy JM; Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada (H.B., L.D., L.P., G.T., J.M.B.).; Department of Medicine, McGill University Health Centre, Montreal, QC, Canada (L.P., J.M.B.)., Pare G; Department of Pathology and Molecular Medicine, McMaster University (G.P.).; Population Health Research Institute, Hamilton, ON, Canada (G.P.)., Horne BD; Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A., B.D.H).; Department of Biomedical Informatics (B.D.H.), University of Utah, Salt Lake City., März W; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (G.D., M. 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Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.; Division of Heart and Lungs, Department of Cardiology (V.T., A.F.S.,D.K.,F.W.A.), UMC Utrecht, the Netherlands.; Durrer Centre of Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht (F.W.A.).

Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2019 Apr; Vol. 12 (4), pp. e002470. Date of Electronic Publication: 2019 Mar 21.

PCN278 - The Cost-Effectiveness Threshold in Cancer Therapy – is This A Good Idea?

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Clinical significance of anti-domain 1 β2-glycoprotein I antibodies in antiphospholipid syndrome.

Autor: Iwaniec T; Department of Medicine, Jagiellonian University Medical College, Kraków, Poland., Kaczor MP; Department of Medicine, Jagiellonian University Medical College, Kraków, Poland., Celińska-Löwenhoff M; Department of Medicine, Jagiellonian University Medical College, Kraków, Poland., Polański S; Department of Medicine, Jagiellonian University Medical College, Kraków, Poland., Musiał J; Department of Medicine, Jagiellonian University Medical College, Kraków, Poland. Electronic address: mmmusia@cyf-kr.edu.pl.

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