Organizing principles of astrocytic nanoarchitecture in the mouse cerebral cortex

Autor: Salmon, Christopher K., Syed, Tabish A., Kacerovsky, J. Benjamin, Alivodej, Nensi, Schober, Alexandra L., Sloan, Tyler F.W., Pratte, Michael T., Rosen, Michael P., Green, Miranda, Chirgwin-Dasgupta, Adario, Mehta, Shaurya, Jilani, Affan, Wang, Yanan, Vali, Hojatollah, Mandato, Craig A., Siddiqi, Kaleem, Murai, Keith K.

Publikováno v: In Current Biology 13 March 2023 33(5):957-972

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Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics.

Autor: Ponroy Bally B; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada., Farmer WT; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada., Jones EV; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada., Jessa S; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.; Quantitative Life Sciences, McGill University, Montreal, QC H3A 2A7, Canada., Kacerovsky JB; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada., Mayran A; Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada., Peng H; Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada.; Department of Human Genetics, McGill University, Montreal, QC H4H 1R3, Canada.; Douglas Hospital Research Institute, Verdun, QC H4H 1R3, Canada., Lefebvre JL; Department of Molecular Genetics, Program for Neuroscience and Mental Health, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada., Drouin J; Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada., Hayer A; Department of Biology, McGill University, Bellini Life Sciences Complex, Montreal, QC H3G 0B1, Canada., Ernst C; Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada.; Department of Human Genetics, McGill University, Montreal, QC H4H 1R3, Canada.; Douglas Hospital Research Institute, Verdun, QC H4H 1R3, Canada., Murai KK; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.; Quantitative Life Sciences, McGill University, Montreal, QC H3A 2A7, Canada.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2020 Mar 27; Vol. 29 (5), pp. 785-802.