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Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres.
Autor:
Yang Q; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Lachapelle EA; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kablaoui NM; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Webb D; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Popiolek M; Internal Medicine Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Grimwood S; Internal Medicine Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kozak R; Internal Medicine Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., O'Connor RE; Discovery Sciences, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States., Lazzaro JT; Discovery Sciences, Pfizer Inc., 445 Eastern Point Road, Groton, Connecticut 06340, United States., Butler CR; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States., Zhang L; Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 May 28; Vol. 10 (6), pp. 941-948. Date of Electronic Publication: 2019 May 28 (Print Publication: 2019).
Autor:
Price DA; Pfizer Inc. Medicine Design, 610 Main Street, Cambridge, Massachusetts, 02155 USA. david.a.price@pfizer.com., Eng H, Farley KA, Goetz GH, Huang Y, Jiao Z, Kalgutkar AS, Kablaoui NM, Khunte B, Liras S, Limberakis C, Mathiowetz AM, Ruggeri RB, Quan JM, Yang Z
Publikováno v:
Organic & biomolecular chemistry [Org Biomol Chem] 2017 Mar 28; Vol. 15 (12), pp. 2501-2506. Date of Electronic Publication: 2017 Mar 07.
Autor:
Sciabola S; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Neuroscience, 610 Main Street, Cambridge, MA 02139, USA., Goetz GH; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA., Bai G; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA., Rogers BN; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Neuroscience, 610 Main Street, Cambridge, MA 02139, USA., Gray DL; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Neuroscience, 610 Main Street, Cambridge, MA 02139, USA., Duplantier A; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Neuroscience, 610 Main Street, Cambridge, MA 02139, USA., Fonseca KR; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Cambridge, MA 02139, USA., Vanase-Frawley MA; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA., Kablaoui NM; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Neuroscience, 610 Main Street, Cambridge, MA 02139, USA. Electronic address: Natasha.M.Kablaoui@pfizer.com.
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Aug 15; Vol. 24 (16), pp. 3513-20. Date of Electronic Publication: 2016 May 31.
Autor:
Modi ME; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Majchrzak MJ; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Fonseca KR; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Doran A; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Osgood S; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Vanase-Frawley M; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Feyfant E; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., McInnes H; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Darvari R; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Buhl DL; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.)., Kablaoui NM; Neuroscience and Pain Research Unit (M.E.M., M.J.M., D.L.B.), Department of Pharmacokinetics, Dynamics and Metabolism (K.R.F.), Global Biotherapeutics Technologies (E.F.), and Worldwide Medicinal Chemistry (N.M.K.), Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts; Department of Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut (A.D., S.O., M.V.-F.); and Biotherapuetics Pharmaceutical Research and Development, Worldwide Research and Development, Pfizer Inc., Andover, Massachusetts (H.M., R.D.) Natasha.M.Kablaoui@pfizer.com.
Publikováno v:
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2016 Aug; Vol. 358 (2), pp. 164-72. Date of Electronic Publication: 2016 May 23.
Autor:
Walker DP; Pfizer Worldwide Medicinal Chemistry, Pfizer Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA. dpwalker@kalexsyn.com, Arhancet GB, Lu HF, Heasley SE, Metz S, Kablaoui NM, Franco FM, Hanau CE, Scholten JA, Springer JR, Fobian YM, Carter JS, Xing L, Yang S, Shaffer AF, Jerome GM, Baratta MT, Moore WM, Vazquez ML
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Feb 15; Vol. 23 (4), pp. 1120-6. Date of Electronic Publication: 2012 Dec 12.
Autor:
Ye P; Cambridge South Laboratory, Pfizer Inc., 620 Memorial Drive, Cambridge, MA 02139, United States., Kuhn C, Juan M, Sharma R, Connolly B, Alton G, Liu H, Stanton R, Kablaoui NM
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jan 15; Vol. 21 (2), pp. 849-52. Date of Electronic Publication: 2010 Nov 21.